Understanding the generation and function of memory T cell subsets

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Tolerogenic Dendritic Cells

2003 • 3,131 citations

Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance

2004 • 2,910 citations

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

2001 • 1,922 citations

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

2003 • 1,790 citations

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

2002 • 1,733 citations

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

2003 • 1,623 citations

Retinoic Acid Imprints Gut-Homing Specificity on T Cells

2004 • 1,460 citations

Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells

2000 • 1,175 citations

Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells

2003 • 1,058 citations

Visualizing the generation of memory CD4 T cells in the whole body

2001 • 1,029 citations

Skewed maturation of memory HIV-specific CD8 T lymphocytes

2001 • 1,025 citations

Molecular and Functional Profiling of Memory CD8 T Cell Differentiation

2002 • 962 citations

Duration of antiviral immunity after smallpox vaccination

2003 • 901 citations

Cytokine control of memory T-cell development and survival

2003 • 885 citations

Dynamics of T Lymphocyte Responses: Intermediates, Effectors, and Memory Cells

2000 • 807 citations

Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells

2002 • 783 citations

T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells

2004 • 703 citations

CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection

2004 • 653 citations

A Role for CD40 Expression on CD8 ⁺ T Cells in the Generation of CD8 ⁺ T Cell Memory

2002 • 629 citations

CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death

2005 • 598 citations

Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells

2002 • 588 citations

Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines

2003 • 582 citations

Cytokine-driven Proliferation and Differentiation of Human Naive, Central Memory, and Effector Memory CD4+ T Cells

2001 • 538 citations

T Cell Memory

2002 • 529 citations

Migratory Properties of Naive, Effector, and Memory Cd8+ T Cells

2001 • 514 citations

Progressive differentiation and selection of the fittest in the immune response

2002 • 503 citations

Antigen-independent memory CD8 T cells do not develop during chronic viral infection

2004 • 489 citations

ON IMMUNOLOGICAL MEMORY

1996 • 482 citations

Pathways of Apoptosis in Lymphocyte Development, Homeostasis, and Disease

2002 • 482 citations

T cell fitness determined by signal strength

2003 • 478 citations

Development and Homeostasis of T Cell Memory in Rhesus Macaque

2002 • 475 citations

Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8 ⁺ memory T cell subsets

2004 • 466 citations

Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

2003 • 454 citations

Dynamics of Blood-Borne CD8 Memory T Cell Migration In Vivo

2004 • 371 citations

Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity

2004 • 354 citations

Memory and flexibility of cytokine gene expression as separable properties of human TH1 and TH2 lymphocytes

2002 • 353 citations

Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites

2004 • 348 citations

CD4 Effector T Cell Subsets in the Response to Influenza

2002 • 328 citations

Epitope-specific Evolution of Human CD8+ T Cell Responses from Primary to Persistent Phases of Epstein-Barr Virus Infection

2002 • 310 citations

IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory Cells

2003 • 307 citations

Priming of Memory But Not Effector CD8 T Cells by a Killed Bacterial Vaccine

2001 • 294 citations

Overexpression of Interleukin (IL)-7 Leads to IL-15–independent Generation of Memory Phenotype CD8+ T Cells

2002 • 291 citations

Chemokine Receptor Expression Identifies Pre–T Helper (Th)1, Pre–Th2, and Nonpolarized Cells among Human CD4+ Central Memory T Cells

2004 • 289 citations

Distinct lineages of TH1 cells have differential capacities for memory cell generation in vivo

2002 • 289 citations

Functional Heterogeneity of Memory CD4 T Cell Responses in Different Conditions of Antigen Exposure and Persistence

2005 • 287 citations

Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype.

1994 • 282 citations

Immediate Cytotoxicity But Not Degranulation Distinguishes Effector and Memory Subsets of CD8+ T Cells

2004 • 265 citations

Arrested Differentiation, the Self-Renewing Memory Lymphocyte, and Vaccination

2001 • 264 citations

Unique gene expression program of human germinal center T helper cells

2004 • 246 citations

Characterization of the CD4+ T Cell Response to Epstein-Barr Virus during Primary and Persistent Infection

2003 • 226 citations

Epitope dominance, competition and T cell affinity maturation

2003 • 213 citations

Rapid Turnover of Effector–Memory CD4+ T Cells in Healthy Humans

2004 • 200 citations

Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions

2003 • 191 citations

Dendritic Cell Immunization Route Determines CD8+ T Cell Trafficking to Inflamed Skin: Role for Tissue Microenvironment and Dendritic Cells in Establishment of T Cell-Homing Subsets

2004 • 191 citations

Phenotypic heterogeneity of antigen‐specific CD4 T cells under different conditions of antigen persistence and antigen load

2004 • 184 citations

Migration and Function of Antigen-Primed Nonpolarized T Lymphocytes in Vivo

2001 • 176 citations

Inverse correlation between IL‐7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation

2005 • 170 citations

Shortening the Infectious Period Does Not Alter Expansion of CD8 T Cells but Diminishes Their Capacity to Differentiate into Memory Cells

2004 • 159 citations

The Repertoires of Circulating Human CD8+ Central and Effector Memory T Cell Subsets Are Largely Distinct

2003 • 154 citations

Lineage relationships, homeostasis, and recall capacities of central– and effector–memory CD8 T cells in vivo

2005 • 144 citations

Separable effector T cell populations specialized for B cell help or tissue inflammation

2001 • 138 citations

Measurement and modeling of human T cell kinetics

2003 • 128 citations

Fully Functional Memory CD8 T Cells in the Absence of CD4 T Cells

2004 • 128 citations

IL-15/IL-15Rα-mediated avidity maturation of memory CD8⁺T cells

2004 • 126 citations

T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification

2002 • 114 citations

CXCR5+ T cells: follicular homing takes center stage in T-helper-cell responses

2002 • 111 citations

High expression of active CDK6 in the cytoplasm of CD8 memory cells favors rapid division

2003 • 108 citations

Maintenance of memory CTL responses by T helper cells and CD40‐CD40 ligand: antibodies provide the key

2004 • 68 citations

Memory T‐cell competition for bone marrow seeding

2003 • 63 citations