OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice

Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10

2000 • 1,406 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

Expression and function of OX40 ligand on human dendritic cells.

1997 • 416 citations

Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases.

1997 • 397 citations

The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion

2000 • 395 citations

Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion.

1996 • 349 citations

Ox40-Ligand Has a Critical Costimulatory Role in Dendritic Cell:T Cell Interactions

1999 • 320 citations

Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate sodium-induced colitis in mice

1997 • 314 citations

Interferon-gamma (IFN-γ)- and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice

1999 • 298 citations

Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand

2000 • 284 citations

Compromised Ox40 Function in Cd28-Deficient Mice Is Linked with Failure to Develop Cxc Chemokine Receptor 5–Positive Cd4 Cells and Germinal Centers

1999 • 275 citations

OX40 Costimulation Enhances Interleukin-4 (IL-4) Expression at Priming and Promotes the Differentiation of Naive Human CD4+ T Cells Into High IL-4–Producing Effectors

1998 • 247 citations

Signaling through OX40 (CD134) breaks peripheral T-cell tolerance

2001 • 235 citations

Critical Contribution of Ox40 Ligand to T Helper Cell Type 2 Differentiation in Experimental Leishmaniasis

2000 • 235 citations

Danger and OX40 Receptor Signaling Synergize to Enhance Memory T Cell Survival by Inhibiting Peripheral Deletion

2000 • 222 citations

Expression of lymphocyte-endothelial receptor-ligand pairs, alpha 4beta 7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease

1999 • 214 citations

CD134L Expression on Dendritic Cells in the Mesenteric Lymph Nodes Drives Colitis in T Cell-Restored SCID Mice

2001 • 207 citations

Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions.

1993 • 205 citations

Development of Allergic Inflammation in a Murine Model of Asthma Is Dependent on the Costimulatory Receptor Ox40

2001 • 204 citations

CD4 T cell traffic control:in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles

1999 • 190 citations

OX40 Costimulation Enhances Interleukin-4 (IL-4) Expression at Priming and Promotes the Differentiation of Naive Human CD4+ T Cells Into High IL-4–Producing Effectors

1998 • 181 citations

Regulation of T Cell Activation In Vitro and In Vivo by Targeting the OX40-OX40 Ligand Interaction: Amelioration of Ongoing Inflammatory Bowel Disease with an OX40-IgG Fusion Protein, But Not with an OX40 Ligand-IgG Fusion Protein

1999 • 172 citations

B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue

2002 • 157 citations

Early appearance of "natural" mucosal IgA responses and germinal centers in suckling mice developing in the absence of maternal antibodies.

1995 • 132 citations

Constitutive OX40/OX40 Ligand Interaction Induces Autoimmune-Like Diseases

2002 • 120 citations

CXCR5+ T cells: follicular homing takes center stage in T-helper-cell responses

2002 • 111 citations

Amelioration of Experimental Autoimmune Encephalomyelitis with Anti-OX40 Ligand Monoclonal Antibody: A Critical Role for OX40 Ligand in Migration, But Not Development, of Pathogenic T Cells

2001 • 110 citations

Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation

2002 • 108 citations

Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation

2000 • 105 citations

Cutting Edge: Induction of Follicular Homing Precedes Effector Th Cell Development

2001 • 103 citations

Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD154 administration

2000 • 99 citations

Ox40 Costimulation Enhances the Development of T Cell Responses Induced by Dendritic Cells In Vivo

2002 • 98 citations

Colitis Induced by Enteric Bacterial Antigen-Specific CD4+ T Cells Requires CD40-CD40 Ligand Interactions for a Sustained Increase in Mucosal IL-12

2000 • 94 citations

Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40

2000 • 93 citations

Antisense Oligonucleotide Blockade of Tumor Necrosis Factor-α in Two Murine Models of Colitis

2003 • 91 citations

CD40 and CD86 upregulation with divergent CMRF44 expression on blood dendritic cells in inflammatory bowel diseases

2001 • 73 citations

Functional expression of costimulatory molecule CD86 on epithelial cells in the inflamed colonic mucosa

1999 • 69 citations

Etiology and pathophysiology of inflammatory bowel disease--environmental factors.

2000 • 57 citations

Multiple Levels of Activation of Murine CD8+ Intraepithelial Lymphocytes Defined by OX40 (CD134) Expression: Effects on Cell-Mediated Cytotoxicity, IFN-γ, and IL-10 Regulation

2001 • 55 citations

Lymphocyte traffic control by chemokines: follicular B helper T cells

2003 • 48 citations

Expression of costimulatory molecules B7-1 and B7-2 in macrophages and granulomas of Crohn's disease: demonstration of cell-to-cell contact with T lymphocytes.

1997 • 34 citations

Expression of B7 costimulatory molecules by cells infiltrating the colon in experimental colitis induced by oral dextran sulfate sodium in the mouse

2001 • 17 citations

Mucosal damage in chronic DSS-colitis mice is mediated by IL-12 and prevented by IL-10

1998 • 2 citations