Aged Mice Develop Protective Antitumor Immune Responses with Appropriate Costimulation

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

2003 • 1,623 citations

Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

2003 • 1,220 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

Cancer vaccines: between the idea and the reality

2003 • 616 citations

Cancer burden in the aged: an epidemiologic and demographic overview.

1997 • 550 citations

Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses

1998 • 515 citations

Cancer burden in the aged

1997 • 443 citations

Engagement of the OX-40 Receptor In Vivo Enhances Antitumor Immunity

2000 • 386 citations

Differentiation of Naive CTL to Effector and Memory CTL: Correlation of Effector Function with Phenotype and Cell Division

1998 • 379 citations

Immune response to green fluorescent protein: implications for gene therapy

1999 • 324 citations

Antigen-independent changes in naive CD4 T cells with aging.

1996 • 240 citations

Therapeutic efficacy of OX-40 receptor antibody depends on tumor immunogenicity and anatomic site of tumor growth.

2000 • 196 citations

Immunogenicity of enhanced green fluorescent protein (EGFP) in BALB/c mice: identification of an H2-Kd-restricted CTL epitope

2000 • 177 citations

The TNF Superfamily Members LIGHT and CD154 (CD40 Ligand) Costimulate Induction of Dendritic Cell Maturation and Elicit Specific CTL Activity

2001 • 171 citations

Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells

2000 • 163 citations

Cell-mediated immunity in aged mice: an underlying lesion in IL 2 synthesis.

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Immunosenescence: a review

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Costimulation of tumor-reactive CD4+ and CD8+ T lymphocytes by B7, a natural ligand for CD28, can be used to treat established mouse melanoma.

1994 • 145 citations

Heterogeneous T-cell response to MAGE-A10(254-262): high avidity-specific cytolytic T lymphocytes show superior antitumor activity.

2001 • 134 citations

Tumour necrosis factor-α-induced migration of human Langerhans cells: the influence of ageing

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The frail elderly: role of dendritic cells in the susceptibility of infection

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Age-related effects in T cell activation and proliferation

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Humoral immunity in aging

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Cytokine production by T lymphocytes from young and aged mice.

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Ox40 Costimulation Enhances the Development of T Cell Responses Induced by Dendritic Cells In Vivo

2002 • 98 citations

Costimulatory wars: the tumor menace

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Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin‐1β

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Molecular and cellular basis of immunosenescence

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Splenic and inguinal lymph node T cells of aged mice respond differently to polyclonal and antigen-specific stimuli

1992 • 67 citations

Efficacy of cancer gene therapy in aging: adenocarcinoma cells engineered to release IL-2 are rejected but do not induce tumor specific immune memory in old mice

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Cutting Edge: A Crucial Role for B7-CD28 in Transmitting T Help from APC to CTL

2002 • 60 citations

Heterogeneous effects of B7‐1 and B7‐2 in the induction of both protective and therapeutic anti‐tumor immunity against different mouse tumors

1996 • 59 citations

The effect of age on the antigen-presenting mechanism in limiting dilution precursor cell frequency analysis

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CD8⁺ T‐cell clones in old mice

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Ex vivo analysis of tumor antigen specific CD8+ T cell responses using MHC/peptide tetramers in cancer patients

2001 • 47 citations

Age‐related decrement in cytotoxic T lymphocyte (CTL) activity is associated with decreased levels of mRNA encoded by two CTL‐associated serine esterase genes and the perforin gene in mice

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OX40 Ligation Enhances Cell Cycle Turnover of Ag-Activated CD4 T Cells in Vivo

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Early Antigen-Specific Response by Naive CD8 T Cells Is Not Altered with Aging

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Dendritic cells in old age-neglected by gerontology?

2001 • 32 citations

The Age-Dependent Cytokine Production by Murine CD8+ T Cells as Determined by Four-Color Flow Cytometry Analysis

1999 • 28 citations

Active antitumor immunotherapy, with or without B7-mediated costimulation, increases tumor progression in an immunogenic murine T cell lymphoma model

1998 • 21 citations

Tailoring cancer vaccines to the elderly: the importance of suitable mouse models

2001 • 18 citations