4‐1BB and OX40 stimulation enhance CD8 and CD4 T‐cell responses to a DNA prime, poxvirus boost vaccine

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses

1998 • 515 citations

Inducible T cell antigen 4-1BB. Analysis of expression and function.

1993 • 416 citations

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

1995 • 398 citations

The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion

2000 • 395 citations

Engagement of the OX-40 Receptor In Vivo Enhances Antitumor Immunity

2000 • 386 citations

Cutting Edge: 4-1BB Is a Bona Fide CD8 T Cell Survival Signal

1999 • 379 citations

4-1BB Ligand Induces Cell Division, Sustains Survival, and Enhances Effector Function of CD4 and CD8 T Cells with Similar Efficacy

2001 • 352 citations

Costimulation of CD28- T lymphocytes by 4-1BB ligand.

1997 • 333 citations

OX40-Deficient Mice Are Defective in Th Cell Proliferation but Are Competent in Generating B Cell and CTL Responses after Virus Infection

1999 • 320 citations

Analysis of 4-1BB Ligand (4-1BBL)-Deficient Mice and of Mice Lacking Both 4-1BBL and CD28 Reveals a Role for 4-1BBL in Skin Allograft Rejection and in the Cytotoxic T Cell Response to Influenza Virus

1999 • 280 citations

Temporal Segregation of 4-1BB Versus CD28-Mediated Costimulation: 4-1BB Ligand Influences T Cell Numbers Late in the Primary Response and Regulates the Size of the T Cell Memory Response Following Influenza Infection

2002 • 270 citations

4-1BB Ligand, a Member of the TNF Family, Is Important for the Generation of Antiviral CD8 T Cell Responses

1999 • 259 citations

Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death.

1997 • 256 citations

Blocking OX-40/OX-40 Ligand Interaction In Vitro and In Vivo Leads to Decreased T Cell Function and Amelioration of Experimental Allergic Encephalomyelitis

1999 • 250 citations

Enhancement of MHC class I-restricted peptide-specific T cell induction by a DNA prime/MVA boost vaccination regime

1998 • 227 citations

Antigen processing in vivo and the elicitation of primary CTL responses.

1995 • 226 citations

4‐1BB T‐cell antigen binds to mature B cells and macrophages, and costimulates anti‐μ‐primed splenic B cells

1994 • 223 citations

Danger and OX40 Receptor Signaling Synergize to Enhance Memory T Cell Survival by Inhibiting Peripheral Deletion

2000 • 222 citations

In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses

2002 • 195 citations

Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB

2002 • 162 citations

4-1BB Costimulation Is Required for Protective Anti-Viral Immunity After Peptide Vaccination

2000 • 143 citations

Engagement of OX40 Enhances Antigen-Specific CD4+ T Cell Mobilization/Memory Development and Humoral Immunity: Comparison of αOX-40 with αCTLA-4

2001 • 99 citations

Anti‐OX40 stimulation in vivo enhances CD8⁺ memory T cell survival and significantly increases recall responses

2006 • 95 citations

In Vivo Triggering Through 4-1BB Enables Th-Independent Priming of CTL in the Presence of an Intact CD28 Costimulatory Pathway

2002 • 92 citations

Immunogenicities of intravenous and intramuscular administrations of modified vaccinia virus Ankara-based multi-CTL epitope vaccine for human immunodeficiency virus type 1 in mice.

1998 • 84 citations

Augmentation Versus Inhibition: Effects of Conjunctional OX-40 Receptor Monoclonal Antibody and IL-2 Treatment on Adoptive Immunotherapy of Advanced Tumor

2001 • 78 citations

Cytokine, Chemokine, and Costimulatory Molecule Modulation to Enhance Efficacy of HIV Vaccines

2003 • 76 citations

Development of a DNA-MVA/HIVA vaccine for Kenya

2002 • 74 citations

Functional analysis of T-cell antigen 4-1BB in activated intestinal intra-epithelial T lymphocytes

1994 • 21 citations