OX40 (CD134) Controls Memory T Helper 2 Cells that Drive Lung Inflammation

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

1998 • 1,460 citations

IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY HYPERRESPONSIVENESS

1999 • 1,047 citations

Allergen-specific Th1 cells fail to counterbalance Th2 cell–induced airway hyperreactivity but cause severe airway inflammation

1999 • 642 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

Asthma: an epidemic of dysregulated immunity

2002 • 613 citations

Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses

1998 • 515 citations

The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses

2000 • 507 citations

Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells.

1994 • 498 citations

Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production

1997 • 464 citations

Expression and function of OX40 ligand on human dendritic cells.

1997 • 416 citations

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

1995 • 398 citations

The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion

2000 • 395 citations

Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor.

1990 • 375 citations

OX40-Deficient Mice Are Defective in Th Cell Proliferation but Are Competent in Generating B Cell and CTL Responses after Virus Infection

1999 • 320 citations

Ox40-Ligand Has a Critical Costimulatory Role in Dendritic Cell:T Cell Interactions

1999 • 320 citations

Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34.

1994 • 284 citations

Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand

2000 • 284 citations

ICOS is critical for T helper cell–mediated lung mucosal inflammatory responses

2001 • 273 citations

Differential activation requirements for virgin and memory T cells.

1988 • 271 citations

Blocking OX-40/OX-40 Ligand Interaction In Vitro and In Vivo Leads to Decreased T Cell Function and Amelioration of Experimental Allergic Encephalomyelitis

1999 • 250 citations

Signaling through OX40 (CD134) breaks peripheral T-cell tolerance

2001 • 235 citations

Critical Contribution of Ox40 Ligand to T Helper Cell Type 2 Differentiation in Experimental Leishmaniasis

2000 • 235 citations

Danger and OX40 Receptor Signaling Synergize to Enhance Memory T Cell Survival by Inhibiting Peripheral Deletion

2000 • 222 citations

Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions.

1993 • 205 citations

Development of Allergic Inflammation in a Murine Model of Asthma Is Dependent on the Costimulatory Receptor Ox40

2001 • 204 citations

Differential T Cell Function and Fate in Lymph Node and Nonlymphoid Tissues

2002 • 197 citations

CD4+ T cell effectors can become memory cells with high efficiency and without further division

2001 • 186 citations

CD28-Independent Costimulation of T Cells by OX40 Ligand and CD70 on Activated B Cells

1999 • 180 citations

Regulation of T Cell Activation In Vitro and In Vivo by Targeting the OX40-OX40 Ligand Interaction: Amelioration of Ongoing Inflammatory Bowel Disease with an OX40-IgG Fusion Protein, But Not with an OX40 Ligand-IgG Fusion Protein

1999 • 172 citations

Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis

2000 • 151 citations

Activation of naive, memory and effector T cells

1994 • 141 citations

Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis

2000 • 138 citations

Amelioration of Experimental Autoimmune Encephalomyelitis with Anti-OX40 Ligand Monoclonal Antibody: A Critical Role for OX40 Ligand in Migration, But Not Development, of Pathogenic T Cells

2001 • 110 citations

Activation requirements for CD4+ T cells differing in CD45R expression.

1992 • 107 citations

Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation

2000 • 105 citations

Withdrawal of Stimulation May Initiate the Transition of Effector to Memory CD4 Cells

2002 • 58 citations

Affinity and Kinetics of the Interaction between Soluble Trimeric OX40 Ligand, a Member of the Tumor Necrosis Factor Superfamily, and Its Receptor OX40 on Activated T Cells

1997 • 52 citations

CTLA4-Ig inhibits optimal T helper 2 cell development but not protective immunity or memory response toNippostrongylus brasiliensis

1999 • 45 citations

Requirement of CTLA-4 counter receptors for IL-4 but not IL-10 elevations during a primary systemic in vivo immune response.

1995 • 45 citations

H. polygyrus:B7-Independence of the Secondary Type 2 Response

1996 • 36 citations

Dynamics of antigen-specific helper T cells at the initiation of airway eosinophilic inflammation

2001 • 28 citations