Regulation of CD4 T cell memory by OX40 (CD134)

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance

2004 • 2,910 citations

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

Effector and memory T-cell differentiation: implications for vaccine development

2002 • 1,757 citations

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

2000 • 1,578 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY HYPERRESPONSIVENESS

1999 • 1,047 citations

The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells

1998 • 890 citations

T CELL MEMORY

1998 • 863 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

A<scp>sthma</scp>: Mechanisms of Disease Persistence and Progression

2004 • 814 citations

Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells

2002 • 783 citations

CD28-mediated co-stimulation: a quantitative support for TCR signalling

2003 • 713 citations

Developing Lymph Nodes Collect CD4 + CD3 − LTβ + Cells That Can Differentiate to APC, NK Cells, and Follicular Cells but Not T or B Cells

1997 • 654 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma

2005 • 610 citations

Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses

1998 • 515 citations

Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells.

1994 • 498 citations

Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

2003 • 454 citations

Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells

2003 • 449 citations

Class II-Independent Generation of CD4 Memory T Cells from Effectors

1999 • 422 citations

Expression and function of OX40 ligand on human dendritic cells.

1997 • 416 citations

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

1995 • 398 citations

The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion

2000 • 395 citations

Toll-Like Receptor Ligands Directly Promote Activated CD4+ T Cell Survival

2004 • 389 citations

T cell memory is short-lived in the absence of antigen.

1991 • 367 citations

T Cell Stimulation In Vivo by Lipopolysaccharide (LPS)

1997 • 335 citations

Functional Responses and Costimulator Dependence of Memory CD4+ T Cells

2000 • 318 citations

γ chain required for naïve CD4+ T cell survival but not for antigen proliferation

2000 • 314 citations

IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory Cells

2003 • 307 citations

A direct role for IFN-gamma in regulation of Th1 cell development.

1996 • 304 citations

Protection from Respiratory Virus Infections Can Be Mediated by Antigen-Specific Cd4+ T Cells That Persist in the Lungs

2001 • 285 citations

Dynamics and Requirements of T Cell Clonal Expansion In Vivo at the Single-Cell Level: Effector Function Is Linked to Proliferative Capacity

1999 • 253 citations

From Naive to Memory T Cells

1996 • 252 citations

Immunological Memory

1993 • 250 citations

OX40 (CD134) Controls Memory T Helper 2 Cells that Drive Lung Inflammation

2003 • 244 citations

T Helper 1 Cells and Interferon γ Regulate Allergic Airway Inflammation and Mucus Production

1999 • 243 citations

Signaling through OX40 (CD134) breaks peripheral T-cell tolerance

2001 • 235 citations

Costimulation via OX40L Expressed by B Cells Is Sufficient to Determine the Extent of Primary CD4 Cell Expansion and Th2 Cytokine Secretion In Vivo

2003 • 235 citations

Costimulation of T cells by OX40, 4-1BB, and CD27

2003 • 229 citations

CD4+CD3− Accessory Cells Costimulate Primed CD4 T Cells through OX40 and CD30 at Sites Where T Cells Collaborate with B Cells

2003 • 226 citations

Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool

2005 • 224 citations

Danger and OX40 Receptor Signaling Synergize to Enhance Memory T Cell Survival by Inhibiting Peripheral Deletion

2000 • 222 citations

Following the Development of a CD4 T Cell Response In Vivo

1999 • 213 citations

Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool

2005 • 212 citations

The costimulation-regulated duration of PKB activation controls T cell longevity

2004 • 208 citations

Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions.

1993 • 205 citations

A Restricted Subset of Dendritic Cells Captures Airborne Antigens and Remains Able to Activate Specific T Cells Long after Antigen Exposure

2002 • 204 citations

Development of Allergic Inflammation in a Murine Model of Asthma Is Dependent on the Costimulatory Receptor Ox40

2001 • 204 citations

Interleukin-5–producing CD4⁺ T Cells Play a Pivotal Role in Aeroallergen-induced Eosinophilia, Bronchial Hyperreactivity, and Lung Damage in Mice

1998 • 200 citations

Differential T Cell Function and Fate in Lymph Node and Nonlymphoid Tissues

2002 • 197 citations

Bidirectional Interactions between Antigen-bearing Respiratory Tract Dendritic Cells (DCs) and T Cells Precede the Late Phase Reaction in Experimental Asthma

2003 • 192 citations

CD4+ T cell effectors can become memory cells with high efficiency and without further division

2001 • 186 citations

Impairment of immunological memory in the absence of MHC despite survival of memory T cells

2002 • 181 citations

CD28-Independent Costimulation of T Cells by OX40 Ligand and CD70 on Activated B Cells

1999 • 180 citations

Matrix Metalloproteinase-9-Mediated Dendritic Cell Recruitment into the Airways Is a Critical Step in a Mouse Model of Asthma

2003 • 153 citations

OX-40: life beyond the effector T cell stage

1998 • 152 citations

Activation of naive, memory and effector T cells

1994 • 141 citations

OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand

1996 • 138 citations

Heterogeneity of CD4+ and CD8+ T cells

2003 • 136 citations

A Closer Look at Homeostatic Proliferation of CD4+ T Cells: Costimulatory Requirements and Role in Memory Formation

2001 • 130 citations

A role for antigen in the maintenance of immunological memory

2002 • 126 citations

The interplay of dendritic cells, Th2 cells and regulatory T cells in asthma

2004 • 118 citations

Long-Lived Th2 Memory in Experimental Allergic Asthma

2002 • 109 citations

Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation

2002 • 108 citations

An IFN-γ-Dependent Pathway Controls Stimulation of Memory Phenotype CD8+ T Cell Turnover In Vivo by IL-12, IL-18, and IFN-γ

2001 • 106 citations

Repeated Antigen Exposure Is Necessary for the Differentiation, But Not the Initial Proliferation, of Naive CD4+ T Cells

2002 • 102 citations

Engagement of OX40 Enhances Antigen-Specific CD4+ T Cell Mobilization/Memory Development and Humoral Immunity: Comparison of αOX-40 with αCTLA-4

2001 • 99 citations

Initial Antigen Encounter Programs CD8+ T Cells Competent to Develop into Memory Cells That Are Activated in an Antigen-Free, IL-7- and IL-15-Rich Environment

2004 • 99 citations

High Antigen Density and IL-2 Are Required for Generation of CD4 Effectors Secreting Th1 Rather Than Th0 Cytokines

1998 • 74 citations

Generation, persistence, and modulation of Th0 effector cells: role of autocrine IL-4 and IFN-gamma.

1998 • 72 citations

Helper T cell differentiation

1999 • 72 citations

Signaling control of memory T cell generation and function

2004 • 64 citations

Effector CD4 T Cells Are Biochemically Distinct from the Memory Subset: Evidence for Long-Term Persistence of Effectors In Vivo

1999 • 60 citations

The Proliferative Capacity of Individual Naive CD4+T Cells Is Amplified by Prolonged T Cell Antigen Receptor Triggering

2002 • 59 citations

Withdrawal of Stimulation May Initiate the Transition of Effector to Memory CD4 Cells

2002 • 58 citations

Modulation of Naive CD4 T Cell Activation with Altered Peptide Ligands: The Nature of the Peptide and Presentation in the Context of Costimulation Are Critical for a Sustained Response

1998 • 57 citations

Generation, Persistence, and Modulation of Th0 Effector Cells: Role of Autocrine IL-4 and IFN-γ

1998 • 56 citations

Do effector and memory T helper cells also need B7 ligand costimulatory signals?

1997 • 50 citations

CTLA4-Ig inhibits optimal T helper 2 cell development but not protective immunity or memory response toNippostrongylus brasiliensis

1999 • 45 citations

Requirement of CTLA-4 counter receptors for IL-4 but not IL-10 elevations during a primary systemic in vivo immune response.

1995 • 45 citations

The generation and maintenance of memory T and B cells

1999 • 38 citations

H. polygyrus:B7-Independence of the Secondary Type 2 Response

1996 • 36 citations

Availability of antigen-presenting cells can determine the extent of CD4 effector expansion and priming for secretion of Th2 cytokines in vivo

2002 • 35 citations

Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein

1995 • 27 citations

Identification of Rat OX40 Ligand by Molecular Cloning

1998 • 20 citations

Distinct temporal programming of naive CD4⁺ T cells for cell division versus TCR‐dependent death susceptibility by antigen‐presenting macrophages

2005 • 19 citations

Regulation of development and function of memory CD4 subsets.

2000 • 18 citations

Chronic Soluble Antigen Sensitization Primes a Unique Memory/Effector T Cell Repertoire Associated with Th2 Phenotype Acquisition In Vivo

2002 • 17 citations

Characterization of Rat OX40 Ligand by Monoclonal Antibody

2000 • 15 citations

Regulation of Development and Function of Memory CD4 Subsets

2000 • 13 citations

Memory T-cells in non-lymphoid tissues.

2002 • 6 citations