Antagonism of Airway Tolerance by Endotoxin/Lipopolysaccharide through Promoting OX40L and Suppressing Antigen-Specific Foxp3+ T Regulatory Cells

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

2007 • 2,575 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

Reciprocal T _H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

2007 • 1,890 citations

Environmental Exposure to Endotoxin and Its Relation to Asthma in School-Age Children

2002 • 1,810 citations

Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

2001 • 1,212 citations

In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes

2004 • 1,192 citations

Lipopolysaccharide-enhanced, Toll-like Receptor 4–dependent T Helper Cell Type 2 Responses to Inhaled Antigen

2002 • 1,172 citations

IgE in allergy and asthma today

2008 • 1,074 citations

Immune Responses in Healthy and Allergic Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 Cells

2004 • 1,060 citations

TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand

2005 • 1,029 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

Toll-like receptors in the pathogenesis of human disease

2004 • 839 citations

Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells

1997 • 823 citations

Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

2002 • 785 citations

Cytokines in symptomatic asthma airways

1992 • 750 citations

Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma

2005 • 675 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

Severity of asthma is related to endotoxin in house dust.

1996 • 586 citations

Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses

1998 • 515 citations

Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent

2005 • 507 citations

Oral tolerance in the absence of naturally occurring Tregs

2005 • 474 citations

Expression and function of OX40 ligand on human dendritic cells.

1997 • 416 citations

Expression of the potent inflammatory cytokines, granulocyte-macrophage-colony-stimulating factor and interleukin-6 and interleukin-8, in bronchial epithelial cells of patients with asthma

1992 • 408 citations

OX40 costimulation turns off Foxp3+ Tregs

2007 • 398 citations

The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion

2000 • 395 citations

House Dust Endotoxin and Wheeze in the First Year of Life

2001 • 364 citations

The IL-6R α chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo

2005 • 336 citations

Endotoxin exposure in allergy and asthma: Reconciling a paradox

2002 • 331 citations

The IL-6R α chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo

2005 • 295 citations

Conversion of CD4+ CD25− cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus

2005 • 271 citations

The regulation of allergy and asthma

2006 • 263 citations

GATA3-Driven Th2 Responses Inhibit TGF-β1–Induced FOXP3 Expression and the Formation of Regulatory T Cells

2007 • 262 citations

OX40 (CD134) Controls Memory T Helper 2 Cells that Drive Lung Inflammation

2003 • 244 citations

Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3 ⁺ regulatory T cells

2007 • 236 citations

Circulating interleukin-6 levels in patients with bronchial asthma.

1995 • 236 citations

Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25− T Cells

2007 • 220 citations

Regulatory T Cells in Allergy and Asthma

2007 • 214 citations

Regulatory T cells control the development of allergic disease and asthma

2003 • 212 citations

Development of Allergic Inflammation in a Murine Model of Asthma Is Dependent on the Costimulatory Receptor Ox40

2001 • 204 citations

Cutting Edge: OX40 Inhibits TGF-β- and Antigen-Driven Conversion of Naive CD4 T Cells into CD25+Foxp3+ T cells

2007 • 202 citations

In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation

2007 • 197 citations

Regulatory T cells in the periphery

2006 • 189 citations

The levels of CD4+CD25+ regulatory T cells in paediatric patients with allergic rhinitis and bronchial asthma

2007 • 183 citations

Healthy immune response to allergens: T regulatory cells and more

2006 • 167 citations

Nonallergic individuals recognize the same T cell epitopes of Bet v 1, the major birch pollen allergen, as atopic patients.

1995 • 161 citations

Specificity of CD4+CD25+ Regulatory T Cell Function in Alloimmunity

2006 • 121 citations

Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment

2006 • 118 citations

Bee venom phospholipase A2‐specific T cell clones from human allergic and non‐allergic individuals: cytokine patterns change in response to the antigen concentration

1992 • 114 citations

TLR4 Signaling Attenuates Ongoing Allergic Inflammation

2006 • 98 citations

Lipopolysaccharide-Induced Suppression of Airway Th2 Responses Does Not Require IL-12 Production by Dendritic Cells

2003 • 95 citations

Lipopolysaccharide inhalation exacerbates allergic airway inflammation by activating mast cells and promoting Th2 responses

2006 • 61 citations

Accumulation of Regulatory T Cells in Local Draining Lymph Nodes of the Lung Correlates with Spontaneous Resolution of Chronic Asthma in a Murine Model

2007 • 46 citations

Do microbes influence the pathogenesis of allergic diseases? Building the case for Toll-like receptor ligands

2003 • 37 citations

IgE Cross-Linking or Lipopolysaccharide Treatment Induces Recruitment of Th2 Cells to the Lung in the Absence of Specific Antigen

2002 • 27 citations

Antigen and Lipopolysaccharide Play Synergistic Roles in the Effector Phase of Airway Inflammation in Mice

2006 • 27 citations

The costimulatory molecules CD80, CD86 and OX40L are up-regulated inAspergillus fumigatussensitized mice

2005 • 19 citations

Characterization of Rat OX40 Ligand by Monoclonal Antibody

2000 • 15 citations