Selection of the T-Cell Repertoire: Receptor-Controlled Checkpoints in T-Cell Development

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

The Danger Model: A Renewed Sense of Self

2002 • 4,107 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2001 • 1,831 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

1997 • 1,326 citations

Isolation of cDNA clones encoding T cell-specific membrane-associated proteins

1984 • 1,239 citations

Binding of immunogenic peptides to Ia histocompatibility molecules

1985 • 1,209 citations

Histocompatibility-Linked Immune Response Genes

1972 • 1,194 citations

B Cell Development Pathways

2001 • 1,185 citations

Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.

1975 • 1,105 citations

Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro

2002 • 1,095 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES

1973 • 1,046 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

The somatic generation of immune recognition

1971 • 974 citations

Direct Expansion of Functional CD25+ CD4+ Regulatory T Cells by Antigen-processing Dendritic Cells

2003 • 893 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitis

1974 • 832 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

2001 • 799 citations

Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin

1997 • 792 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1

2003 • 771 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

1984 • 719 citations

Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

2002 • 712 citations

THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION

1955 • 700 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Genes and Antibodies

1959 • 675 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice

1999 • 641 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo

2003 • 600 citations

Ikaros DNA-Binding Proteins Direct Formation of Chromatin Remodeling Complexes in Lymphocytes

1999 • 583 citations

Inducible gene knockout of transcription factor recombination signal binding protein‐J reveals its essential role in T versus B lineage decision

2002 • 575 citations

Transfer of specificity by murine α and β T-cell receptor genes

1986 • 568 citations

Positive selection of lymphocytes

1994 • 563 citations

Thymopoiesis independent of common lymphoid progenitors

2003 • 548 citations

In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells

1977 • 534 citations

Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State

2003 • 523 citations

Developmental regulation of T-cell receptor gene expression

1985 • 522 citations

A Thymic Precursor to the NK T Cell Lineage

2002 • 517 citations

Early T Lymphocyte Progenitors

1996 • 473 citations

Isolation and characterization of antigen-la complexes involved in T cell recognition

1986 • 470 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Transcription from the RAG1 Locus Marks the Earliest Lymphocyte Progenitors in Bone Marrow

2002 • 460 citations

Cell-cell adhesion mediated by CD8 and MHC class I molecules

1988 • 445 citations

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

2000 • 420 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells

2001 • 406 citations

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

2000 • 399 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

Notch 1–Deficient Common Lymphoid Precursors Adopt a B Cell Fate in the Thymus

2001 • 392 citations

Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

2002 • 390 citations

Control of Apoptosis in the Immune System: Bcl-2, BH3-Only Proteins and More

2003 • 387 citations

In vivodynamics of antigen-specific regulatory T cells not predicted from behaviorin vitro

2003 • 384 citations

The thymus selects the useful, neglects the useless and destroys the harmful

1989 • 378 citations

Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow.

1992 • 368 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.

1978 • 353 citations

Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation

2001 • 348 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

Requirement for cyclin D3 in lymphocyte development and T cell leukemias

2003 • 336 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire.

1991 • 323 citations

Fine specificity of a continuously growing killer cell clone specific for H-Y antigen

1979 • 317 citations

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

1995 • 305 citations

The Developmental Biology of T Lymphocytes

1988 • 300 citations

Critical Roles for Transcription Factor GATA-3 in Thymocyte Development

2003 • 299 citations

Autoimmune Regulator Is Expressed in the Cells Regulating Immune Tolerance in Thymus Medulla

1999 • 293 citations

Expression of T-cell antigen receptor genes during fetal development in the thymus

1985 • 293 citations

Key Role of flt3 Ligand in Regulation of the Common Lymphoid Progenitor but Not in Maintenance of the Hematopoietic Stem Cell Pool

2002 • 281 citations

NF-κB Activation by the Pre-T Cell Receptor Serves as a Selective Survival Signal in T Lymphocyte Development

2000 • 280 citations

Two-step binding mechanism for T-cell receptor recognition of peptide–MHC

2002 • 279 citations

A LAT Mutation That Inhibits T Cell Development Yet Induces Lymphoproliferation

2002 • 278 citations

Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade

2001 • 276 citations

High Frequency of Autoreactive Myelin Proteolipid Protein–Specific T Cells in the Periphery of Naive Mice

2000 • 275 citations

Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

1993 • 266 citations

Induction of T Helper Type 2 Immunity by a Point Mutation in the LAT Adaptor

2002 • 265 citations

Obligatory Role for Cooperative Signaling by Pre-TCR and Notch during Thymocyte Differentiation

2004 • 254 citations

Ontogeny of the T-cell antigen receptor within the thymus

1985 • 250 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.

1993 • 247 citations

The Clonal-Selection Theory

1987 • 244 citations

Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes

2002 • 244 citations

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

2000 • 244 citations

Positive selection of the T cell repertoire: Where and when does it occur?

1989 • 242 citations

A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors.

1996 • 236 citations

Positive and negative selection invoke distinct signaling pathways.

1996 • 234 citations

Regulation of the TCRα repertoire by the survival window of CD4+CD8+ thymocytes

2002 • 227 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes

1998 • 221 citations

Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.

1993 • 221 citations

The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens

1989 • 219 citations

Differential Roles of ERK and p38 MAP Kinase Pathways in Positive and Negative Selection of T Lymphocytes

1998 • 217 citations

The Influence of the MAPK Pathway on T Cell Lineage Commitment

1997 • 217 citations

Calcineurin B1 Is Essential for Positive but Not Negative Selection during Thymocyte Development

2004 • 216 citations

Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential

2003 • 205 citations

A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity

2000 • 203 citations

The function of E- and id proteins in lymphocyte development

2001 • 203 citations

Promiscuous gene expression and central T-cell tolerance: more than meets the eye

2002 • 198 citations

Subversion of the T/B Lineage Decision in the Thymus by Lunatic Fringe-Mediated Inhibition of Notch-1

2001 • 195 citations

Pro-Thymocyte Expansion by c-kit and the Common Cytokine Receptor γ Chain Is Essential for Repertoire Formation

1997 • 195 citations

Lck Activity Controls CD4/CD8 T Cell Lineage Commitment

2000 • 194 citations

Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse

1975 • 191 citations

CELL INTERACTIONS BETWEEN HISTOINCOMPATIBLE T AND B LYMPHOCYTES

1973 • 190 citations

Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-κB and NFAT

2001 • 189 citations

Thymic selection revisited: how essential is it?

2003 • 186 citations

The differentiation of T lymphocytes

1974 • 185 citations

Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells

2001 • 182 citations

Defective T cell development and function incalcineurinAβ-deficient mice

2002 • 182 citations

Transfection of the CD8 gene enhances T-cell recognition

1987 • 177 citations

Somatic activation of β-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development

2001 • 175 citations

Transcription of a Broad Range of Self-Antigens in Human Thymus Suggests a Role for Central Mechanisms in Tolerance Toward Peripheral Antigens

1998 • 173 citations

Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

2001 • 172 citations

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency

2001 • 165 citations

CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium

1998 • 162 citations

The αβ T Cell Receptor Can Replace the γδ Receptor in the Development of γδ Lineage Cells

1996 • 161 citations

Pre–T Cell Receptor (Tcr) and Tcr-Controlled Checkpoints in T Cell Differentiation Are Set by Ikaros

1999 • 157 citations

Killer cells reactive to altered-self antigens can also be alloreactive.

1977 • 155 citations

The Function and Interrelationships of T‐Cell Receptors, Ir Genes and Other Histocompatibility Gene Products

1975 • 152 citations

Positive selection of MHC class Ib–restricted CD8+ T cells on hematopoietic cells

2002 • 151 citations

The CD8α Gene Locus Is Regulated by the Ikaros Family of Proteins

2002 • 149 citations

Collaboration of histoincompatible T and B lymphocytes using cells from tetraparental bone marrow chimeras.

1975 • 147 citations

Hematopoietic stem cells engraft in mice with absolute efficiency

2003 • 144 citations

Induction of the Early Growth Response (Egr) Family of Transcription Factors during Thymic Selection

1997 • 141 citations

Molecular and Cellular Events in Early Thymocyte Development 11Received for publication October 14, 1997

1998 • 137 citations

Self-antigen presentation by thymic stromal cells: a subtle division of labor

2000 • 135 citations

The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression.

1978 • 134 citations

Expression of two T cell receptor α chains on the surface of normal murine T cells

1995 • 131 citations

Premature Expression of T Cell Receptor (Tcr)αβ Suppresses Tcrγδ Gene Rearrangement but Permits Development of γδ Lineage T Cells

2000 • 123 citations

In-frame TCR δ gene rearrangements play a critical role in the αβ/γδ T cell lineage decision

1995 • 122 citations

Pre-TCR Signaling and Inactivation of p53 Induces Crucial Cell Survival Pathways in Pre-T Cells

1999 • 122 citations

The Clonal Selection Hypothesis Evaluated by Grafted Cells Reacting Against their Hosts

1967 • 121 citations

On the immunocompetence of H-2 incompatible irradiation bone marrow chimeras.

1980 • 118 citations

Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene.

1991 • 116 citations

Anergy and suppression regulate CD4+ T cell responses to a self peptide

2000 • 115 citations

Intrathymic δ Selection Events in γδ Cell Development

1997 • 112 citations

Role of Different T Cell Receptors in the Development of Pre–T Cells

1997 • 108 citations

Restoration of Thymopoiesis in pTα−/− Mice by Anti-CD3ε Antibody Treatment or with Transgenes Encoding Activated Lck or Tailless pTα

1997 • 106 citations

Summary: Waiting for the End

1967 • 102 citations

The selection of the α,β heterodimeric T-cell receptor for antigen

1986 • 100 citations

Identification of the earliest prethymic bipotent T/NK progenitor in murine fetal liver

2002 • 99 citations

The Developmental Biology Of T Lymphocytes

1988 • 98 citations

On the Role of the Pre–T Cell Receptor in αβ versus γδ T Lineage Commitment

1998 • 96 citations

AUTORADIOGRAPHIC ANALYSIS OF LYMPHOPOIESIS AND LYMPHOCYTE MIGRATION IN MICE BEARING MULTIPLE THYMUS GRAFTS

1966 • 95 citations

Thymocyte Development in Early Growth Response Gene 1-Deficient Mice

2002 • 95 citations

Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene

2002 • 93 citations

On the Structure of the T-cell Receptor for Antigen

1977 • 90 citations

The Common Cytokine Receptor γ Chain and the Pre-T Cell Receptor Provide Independent but Critically Overlapping Signals in Early α/β T Cell Development

1999 • 88 citations

Wnt signaling in the thymus

2003 • 82 citations

Virus-specific T-cell-mediated cytotoxicity across the H–2 barrier to virus-altered alloantigen

1976 • 74 citations

The Developmentally Regulated Expression of Twisted Gastrulation Reveals a Role for Bone Morphogenetic Proteins in the Control of T Cell Development

2002 • 74 citations

The Role of Recombination Activating Gene (RAG) Reinduction in Thymocyte Development in Vivo

2001 • 73 citations

Murine Schnurri-2 is required for positive selection of thymocytes

2001 • 72 citations

Positive Selection of a Qa-1-Restricted T Cell Receptor with Specificity for Insulin

2002 • 71 citations

Posttranslational regulation of TCR Valpha allelic exclusion during T cell differentiation.

1998 • 71 citations

Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor Editing

2002 • 71 citations

Extrachromosomal Recombination Substrates Recapitulate beyond 12/23 Restricted V(D)J Recombination in Nonlymphoid Cells

2003 • 71 citations

Impact of Thymus on the Generation of Immunocompetence and Diversity of Antigen‐Specific MHC‐Restricted Cytotoxic T‐Lymphocyte Precursors

1981 • 70 citations

Cytotoxic T lymphocytes recognise allogeneic tolerated TNP-conjugated cells

1976 • 69 citations

Constitutive Endocytosis and Degradation of the Pre-T Cell Receptor

2002 • 69 citations

TOX Provides a Link Between Calcineurin Activation and CD8 Lineage Commitment

2004 • 66 citations

Posttranslational Regulation of TCR Vα Allelic Exclusion During T Cell Differentiation

1998 • 64 citations

Identification and characterization of a human CD4 silencer

1996 • 64 citations

Waiting for the End

1967 • 63 citations

Antigen-binding, Idiotypic Receptors from T Lymphocytes: An Analysis of Their Biochemistry, Genetics, and Use as Immunogens To Produce Specific Immune Tolerance

1977 • 63 citations

In irradiation chimeras, K or D regions of the chimeric host, not of the donor lymphocytes, determine immune responsiveness of antiviral cytotoxic T cells

1978 • 62 citations

Combined Deletion of CD8 Locus cis-Regulatory Elements Affects Initiation but Not Maintenance of CD8 Expression

2002 • 61 citations

Low Activation Threshold As a Mechanism for Ligand-Independent Signaling in Pre-T Cells

2003 • 61 citations

Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors

2003 • 60 citations

The role of dendritic cells in T cell selection and survival

1999 • 59 citations

Pre-TCRα and TCRα Are Not Interchangeable Partners of TCRβ during T Lymphocyte Development

2004 • 57 citations

CD4/CD8 lineage commitment: back to instruction?

1996 • 57 citations

Dramatically Increased Rearrangement and Peripheral Representation of Vβ14 Driven by the 3′Dβ1 Recombination Signal Sequence

2003 • 55 citations

The T-cell accessory molecule CD4 recognizes a monomorphic determinant on isolated Ia.

1988 • 53 citations

Modulation of Thymic Selection by Expression of an Immediate-early Gene, Early Growth Response 1 (Egr-1)

1998 • 50 citations

Variegated Expression of CD8α Resulting from In Situ Deletion of Regulatory Sequences

2002 • 49 citations

Limits to the differential avidity model of T cell selection in the thymus.

1997 • 48 citations

The influence of positive selection on RAG expression in thymocytes

1995 • 46 citations

The CD4/CD8 lineage decision: integration of signalling pathways

2000 • 45 citations

Competitive Displacement of pTα by TCR-α During TCR Assembly Prevents Surface Coexpression of Pre-TCR and αβ TCR

2000 • 42 citations

Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC

2003 • 41 citations

Epigenetic mechanisms that regulate antigen receptor gene expression

2003 • 41 citations

A TCR α chain transgene induces maturation of CD4− CD8− α β+ T cells from γ δ T cell precursors

1998 • 40 citations

The influence of the thymic environment on the CD4-versus-CD8 T lineage decision

2003 • 36 citations

The Impact of Pre-T-cell Receptor Signals on Gene Expression in Developing T Cells

1999 • 33 citations

Clonal Selection Theory

1960 • 31 citations

The Biological Activity of Natural and Mutant Ptα Alleles

2001 • 30 citations

Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras.

1980 • 29 citations

A Role for the Cytoplasmic Tail of the Pre-T Cell Receptor (TCR) α Chain in Promoting Constitutive Internalization and Degradation of the Pre-TCR

2003 • 26 citations

Regulation of thymocyte development: only the meek survive

2003 • 25 citations

How the Immune System Learns about Self

1991 • 24 citations

Macrophage or T cell — that is the question

1981 • 19 citations

The Common Sense of Immunology

1977 • 12 citations

T cell response: nature or nurture

1978 • 1 citations