In-frame TCR δ gene rearrangements play a critical role in the αβ/γδ T cell lineage decision

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Current protocols in molecular biology

1988 • 7,584 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

"Panning" for lymphocytes: a method for cell selection.

1978 • 1,319 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

The Mechanism of V(D)J Joining: Lessons from Molecular, Immunological, and Comparative Analyses

1994 • 579 citations

Positive selection of lymphocytes

1994 • 563 citations

Expression of Two T Cell Receptor α Chains: Dual Receptor T Cells

1993 • 527 citations

Selective Events in T Cell Development

1994 • 486 citations

A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation

1987 • 483 citations

V(D)J Recombination: Molecular Biology and Regulation

1992 • 464 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Diversity, rearrangement, and expression of murine T cell gamma genes

1986 • 405 citations

In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes

1988 • 374 citations

Lymphoid Development in Mice Congenitally Lacking T Cell Receptor αβ-Expressing Cells

1992 • 371 citations

Differential expression of two distinct T-cell receptors during thymocyte development

1987 • 360 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

Kinetics of mature T-cell development in the thymus.

1990 • 331 citations

T-cell receptor δ gene rearrangements in early thymocytes

1987 • 324 citations

The adult T-cell receptor 5-chain is diverse and distinct from that of fetal thymocytes

1988 • 320 citations

T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice

1994 • 305 citations

Regulation of TCR α and β gene allelic exclusion during T-cell development

1992 • 284 citations

Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking

1991 • 270 citations

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.

1993 • 247 citations

Self-reactive γδ T cells are eliminated in the thymus

1990 • 221 citations

Characterization of T Cell Receptor Gamma Chain Expression in a Subset of Murine Thymocytes

1986 • 199 citations

Rearrangement and diversity of T cell receptor β chain genes in thymocytes: A critical role for the β chain in development

1993 • 198 citations

Deletion of the human T-cell receptor δ-gene by a site-specific recombination

1988 • 179 citations

Excision products of the T cell receptor gene support a progressive rearrangement model of the alpha/delta locus.

1989 • 162 citations

Striking sequence similarity over almost 100 kilobases of human and mouse T–cell receptor DNA

1994 • 159 citations

Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression.

1992 • 152 citations

Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitro.

1990 • 143 citations

Organization, structure, and function of 95 kb of DNA spanning the murine T-cell receptor CαCδ region

1992 • 134 citations

T-cell receptor gamma delta and gamma transgenic mice suggest a role of a gamma gene silencer in the generation of alpha beta T cells.

1990 • 128 citations

Isolation of an excision product of T-cell receptor α-chain gene rearrangments

1987 • 124 citations

T cells with two functional antigen-specific receptors.

1995 • 119 citations

Separate lineages of T cells expressing the αβ and γδ receptors

1989 • 118 citations

Regulation of RAG‐1 and CD69 expression in the thymus during positive and negative selection

1994 • 112 citations

Commitment to the T cell receptor‐αβ or ‐γδ lineages can occur just prior to the onset of CD4 and CD8 expression among immature thymocytes

1992 • 110 citations

T cell receptor-gamma and -delta genes preferentially utilized by adult thymocytes for the surface expression.

1989 • 110 citations

An MHC interaction site maps to the amino-terminal half of the T cell receptor α chain variable domain

1992 • 100 citations

Temporal and lineage-specific control of T cell receptor alpha/delta gene rearrangement by T cell receptor alpha and delta enhancers.

1994 • 94 citations

Control of γδ T‐Cell Development

1991 • 93 citations

Enhancer-dependent and -independent steps in the rearrangement of a human T cell receptor delta transgene.

1994 • 85 citations

First T cell receptor alpha gene rearrangements during T cell ontogeny skew to the 5' region of the J alpha locus.

1990 • 84 citations

Blockage of αβ T-cell development by TCR γδ transgenes

1989 • 77 citations

Normal sequence of phenotypic transitions in one cohort of 5-bromo-2'-deoxyuridine-pulse-labeled thymocytes. Correlation with T cell receptor expression.

1993 • 77 citations

Genomic organization of the mouse T cell receptor V alpha family.

1990 • 72 citations

Peripheral murine CD3+, CD4-, CD8- T lymphocytes express novel T cell receptor gamma delta structures.

1988 • 62 citations

Early expression of a T-cell receptor beta-chain transgene suppresses rearrangement of the V gamma 4 gene segment.

1988 • 61 citations

Development and selection of γδ T cells

1992 • 60 citations

Thymocyte circular DNA excised from T cell receptor alpha-delta gene complex.

1988 • 59 citations

The T-cell antigen receptor gamma gene: rearrangement and cell lineages

1987 • 59 citations

Transient rearrangements of the T cell antigen receptor alpha locus in early thymocytes.

1987 • 55 citations

Nucleotide sequence analysis of 95 kb near the 3′ end of the murine T-cell receptor αδ chain locus: Strategy and methodology

1992 • 46 citations

Organization of the V Gene Segments in Mouse T-Cell Antigen Receptor α/δ Locus

1994 • 42 citations

Structure of extrachromosomal circular DNAs excised from T-cell antigen receptor alpha and delta-chain loci

1988 • 42 citations

Developmental T cell receptor gene rearrangements: Relatedness of the α/β and γ/δ T cell precursor

1991 • 38 citations

Rearrangement by inversion of a T-cell receptor delta variable region gene located 3' of the delta constant region gene.

1989 • 34 citations

Development of T cell receptor-gamma delta cells. Phenotypic and functional correlations of T cell receptor-gamma delta thymocyte maturation.

1993 • 23 citations

Expression of T cell receptor genes in the thymus: localization of transcripts in situ and comparison of mature and immature subsets

1990 • 18 citations

Regulation of the early stages of T-cell development

1991 • 11 citations