Thymic selection revisited: how essential is it?

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

The Danger Model: A Renewed Sense of Self

2002 • 4,107 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

Innate immune recognition: mechanisms and pathways

2000 • 1,451 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

1997 • 1,326 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Fundamental Immunology

1999 • 1,011 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

T-cell development and the CD4–CD8 lineage decision

2002 • 738 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

2002 • 564 citations

In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells

1977 • 534 citations

Developmental regulation of T-cell receptor gene expression

1985 • 522 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Early T Lymphocyte Progenitors

1996 • 473 citations

Murine CD1d-Restricted T Cell Recognition of Cellular Lipids

2000 • 467 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

2000 • 399 citations

Notch 1–Deficient Common Lymphoid Precursors Adopt a B Cell Fate in the Thymus

2001 • 392 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

2000 • 365 citations

On the Dynamics of TCR:CD3 Complex Cell Surface Expression and Downmodulation

2000 • 364 citations

STRUCTURE AND FUNCTION OF THE PRE-T CELL RECEPTOR

1997 • 362 citations

Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.

1978 • 353 citations

Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation

2001 • 348 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

Inactivation of Notch1 Impairs VDJβ Rearrangement and Allows pre-TCR-Independent Survival of Early αβ Lineage Thymocytes

2002 • 342 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire.

1991 • 323 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

H-2 antigens of the thymus determinelymphocyte specificity

1978 • 321 citations

αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine Kinases

1996 • 294 citations

Expression of T-cell antigen receptor genes during fetal development in the thymus

1985 • 293 citations

Receptor Editing in a Transgenic Mouse Model: Site, Efficiency, and Role in B Cell Tolerance and Antibody Diversification

1997 • 291 citations

NF-κB Activation by the Pre-T Cell Receptor Serves as a Selective Survival Signal in T Lymphocyte Development

2000 • 280 citations

Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking

1991 • 270 citations

Coreceptor Reversal in the Thymus

2000 • 253 citations

Changes in the VH Gene Repertoire of Developing Precursor B Lymphocytes in Mouse Bone Marrow Mediated by the Pre-B Cell Receptor

1997 • 253 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.

1993 • 247 citations

Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice.

1995 • 245 citations

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

2000 • 244 citations

CD 69 expression during selection and maturation of CD4⁺8⁺ thymocytes

1993 • 242 citations

Developmental Regulation of B Lymphocyte Immune Tolerance Compartmentalizes Clonal Selection from Receptor Selection

1998 • 234 citations

Regulation of the TCRα repertoire by the survival window of CD4+CD8+ thymocytes

2002 • 227 citations

Negative Selection in the Thymus Includes Semimature T Cells

1997 • 224 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

How Many Thymocytes Audition for Selection?

1997 • 222 citations

Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.

1993 • 221 citations

The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens

1989 • 219 citations

Repertoire selection by pre‐B‐cell receptors and B‐cell receptors, and genetic control of B‐cell development from immature to mature B cells

2000 • 216 citations

The third function of the thymus

2000 • 213 citations

Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway

2002 • 204 citations

A T cell clone expresses two T cell receptor α genes but uses one αβ heterodimer for allorecognition and self MHC-restricted antigen recognition

1988 • 200 citations

Pleiotropic changes controlled by the pre-T-cell receptor

1999 • 199 citations

Promiscuous gene expression and central T-cell tolerance: more than meets the eye

2002 • 198 citations

Lck Activity Controls CD4/CD8 T Cell Lineage Commitment

2000 • 194 citations

Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-κB and NFAT

2001 • 189 citations

Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis

2002 • 189 citations

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1997 • 183 citations

Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells

2001 • 182 citations

Somatic activation of β-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development

2001 • 175 citations

Transcription of a Broad Range of Self-Antigens in Human Thymus Suggests a Role for Central Mechanisms in Tolerance Toward Peripheral Antigens

1998 • 173 citations

Tolerance Induced by Thymic Epithelial Grafts in Birds

1987 • 167 citations

CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium

1998 • 162 citations

Hedgehog Signaling Regulates Differentiation from Double-Negative to Double-Positive Thymocyte

2000 • 161 citations

The αβ T Cell Receptor Can Replace the γδ Receptor in the Development of γδ Lineage Cells

1996 • 161 citations

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

1997 • 159 citations

Different initiation of pre-TCR and γδTCR signalling

2000 • 158 citations

Receptor editing in developing T cells

2000 • 157 citations

An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

1994 • 157 citations

Intrathymic Expression of Genes Involved in Organ Specific Autoimmune Disease

1998 • 155 citations

An unusual lineage of alpha/beta T cells that contains autoreactive cells.

1991 • 152 citations

Positive selection of MHC class Ib–restricted CD8+ T cells on hematopoietic cells

2002 • 151 citations

Essential Role of the Pre-T Cell Receptor in Allelic Exclusion of the T Cell Receptor β Locus

1997 • 146 citations

FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

2000 • 142 citations

Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts.

1980 • 139 citations

α β and γ δ T cells can share a late common precursor

1995 • 139 citations

Csk controls antigen receptor-mediated development and selection of T-lineage cells

1998 • 138 citations

Positive and negative regulation of t-cell activation by adaptor proteins

2001 • 137 citations

The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression.

1978 • 134 citations

Expression of two T cell receptor α chains on the surface of normal murine T cells

1995 • 131 citations

Activated Ras signals differentiation and expansion of CD4+8+ thymocytes.

1996 • 130 citations

Allelic Inclusion of T Cell Receptor α Genes Poses an Autoimmune Hazard Due to Low-Level Expression of Autospecific Receptors

1998 • 129 citations

Premature Expression of T Cell Receptor (Tcr)αβ Suppresses Tcrγδ Gene Rearrangement but Permits Development of γδ Lineage T Cells

2000 • 123 citations

In-frame TCR δ gene rearrangements play a critical role in the αβ/γδ T cell lineage decision

1995 • 122 citations

Pre-TCR Signaling and Inactivation of p53 Induces Crucial Cell Survival Pathways in Pre-T Cells

1999 • 122 citations

Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function.

1996 • 121 citations

Dual receptor T cells extend the immune repertoire for foreign antigens

2002 • 121 citations

Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells.

1991 • 121 citations

Immature Thymocytes Employ Distinct Signaling Pathways for Allelic Exclusion versus Differentiation and Expansion

1999 • 120 citations

Evidence That γδ versus αβ T Cell Fate Determination Is Initiated Independently of T Cell Receptor Signaling

2001 • 118 citations

Anergy and suppression regulate CD4+ T cell responses to a self peptide

2000 • 115 citations

Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype.

1995 • 109 citations

In a fully H-2 incompatible chimera, T cells of donor origin can respond to minor histocompatibility antigens in association with either donor or host H-2 type.

1978 • 108 citations

Role of Different T Cell Receptors in the Development of Pre–T Cells

1997 • 108 citations

Rapid deletion of rearranged T cell antigen receptor (TCR) Vα-Jα segment by secondary rearrangement in the thymus: Role of continuous rearrangement of TCR α chain gene and positive selection in the T cell repertoire formation

1998 • 104 citations

On the Role of the Pre–T Cell Receptor in αβ versus γδ T Lineage Commitment

1998 • 96 citations

Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene

2002 • 93 citations

Distinct Signals Mediate Maturation and Allelic Exclusion in Lymphocyte Progenitors

1999 • 89 citations

The joining of germ-line Vα to Jα genes replaces the preexisting Vα-Jα complexes in a T cell receptor α,β positive T cell line

1988 • 87 citations

On the brink of becoming a T cell

2002 • 84 citations

Positive selection of CD4+T cells by TCR ligation without aggregation even in the absence of MHC

1994 • 83 citations

Dual T cell receptor alpha chain T cells in autoimmunity.

1995 • 82 citations

A critical role for the cytoplasmic tail of pTα in T lymphocyte development

2002 • 76 citations

Involvement of the Protein Tyrosine Kinase p56lck in T Cell Signaling and Thymocyte Development

1994 • 75 citations

The Role of Recombination Activating Gene (RAG) Reinduction in Thymocyte Development in Vivo

2001 • 73 citations

Posttranslational regulation of TCR Valpha allelic exclusion during T cell differentiation.

1998 • 71 citations

Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor Editing

2002 • 71 citations

Positive Selection of a Qa-1-Restricted T Cell Receptor with Specificity for Insulin

2002 • 71 citations

Negative Selection of T Cells Occurs Throughout Thymic Development

1999 • 70 citations

Constitutive Endocytosis and Degradation of the Pre-T Cell Receptor

2002 • 69 citations

Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny.

1992 • 67 citations

Cellular competition modulates survival and selection of CD8⁺ T cells

1996 • 66 citations

Posttranslational Regulation of TCR Vα Allelic Exclusion During T Cell Differentiation

1998 • 64 citations

The Absence of Itk Inhibits Positive Selection Without Changing Lineage Commitment

2002 • 63 citations

Premature TCRαβ Expression and Signaling in Early Thymocytes Impair Thymocyte Expansion and Partially Block Their Development

2001 • 62 citations

Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages.

1993 • 62 citations

Combined Deletion of CD8 Locus cis-Regulatory Elements Affects Initiation but Not Maintenance of CD8 Expression

2002 • 61 citations

Marked differences in the efficiency of expression of distinct alphabeta T cell receptor heterodimers

1990 • 57 citations

Evidence that productive rearrangements of TCR γ genes influence the commitment of progenitor cells to differentiate into αβ or γδ T cells

1995 • 52 citations

Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus

1997 • 51 citations

Biased Vβ Usage in Immature Thymocytes Is Independent of DJβ Proximity and pTα Pairing

2001 • 51 citations

Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes

2001 • 49 citations

Positive Selection of an H2-M3 Restricted T Cell Receptor

1999 • 49 citations

Variegated Expression of CD8α Resulting from In Situ Deletion of Regulatory Sequences

2002 • 49 citations

The tight interallelic positional coincidence that distinguishes T-cell receptor Jalpha usage does not result from homologous chromosomal pairing during ValphaJalpha rearrangement

2001 • 48 citations

The CD3-γδε and CD3-ζ/η Modules Are Each Essential for Allelic Exclusion at the T Cell Receptor β Locus but Are Both Dispensable for the Initiation of V to (D)J Recombination at the T Cell Receptor–β, –γ, and –δ Loci

1998 • 47 citations

The influence of positive selection on RAG expression in thymocytes

1995 • 46 citations

Evaluation of the Percentage of Peripheral T Cells with Two Different T Cell Receptor α-Chains and of their Potential Role in Autoimmunity

2001 • 44 citations

A TCR α chain transgene induces maturation of CD4− CD8− α β+ T cells from γ δ T cell precursors

1998 • 40 citations

The T‐Cell Receptor for Antigen in T‐Cell Development and Repertoire Selection

1988 • 37 citations

The Impact of Pre-T-cell Receptor Signals on Gene Expression in Developing T Cells

1999 • 33 citations

Essential and Partially Overlapping Role of CD3γ and CD3δ for Development of αβ and γδ T Lymphocytes

1998 • 33 citations

Antigen‐presenting Function of the TL Antigen and Mouse CD1 Molecules

1995 • 26 citations

Non‐obese diabetic mice hemizygous at the T cell receptor α locus are susceptible to diabetes and sialitis

1996 • 25 citations

Intrathymic T cell receptor (TcR) targeting in mice lacking CD4 or major histocompatibility complex (MHC) class II: Rescue of CD4 T cell lineage without co‐engagement of TcR/CD4 by MHC class II

1995 • 19 citations

Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes

2001 • 17 citations

A season for midwinter immunology

2002 • 3 citations