Calcineurin B1 Is Essential for Positive but Not Negative Selection during Thymocyte Development

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Neuronal specification in the spinal cord: inductive signals and transcriptional codes

2000 • 2,051 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin

1998 • 892 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation

1989 • 679 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice

1999 • 641 citations

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

1998 • 639 citations

The transcription factor NF-ATc is essential for cardiac valve formation

1998 • 580 citations

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1995 • 554 citations

In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells

1977 • 534 citations

L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons

1999 • 521 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

2000 • 420 citations

Signals Transduced by Ca2+/Calcineurin and NFATc3/c4 Pattern the Developing Vasculature

2001 • 412 citations

Dual Inhibition of Sister Chromatid Separation at Metaphase

2001 • 403 citations

A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts

1994 • 402 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

Different Nuclear Signals Are Activated by the B Cell Receptor during Positive Versus Negative Signaling

1997 • 383 citations

Neurotrophins and Netrins Require Calcineurin/NFAT Signaling to Stimulate Outgrowth of Embryonic Axons

2003 • 378 citations

Effects of Cyclosporine A on T Cell Development and Clonal Deletion

1988 • 354 citations

The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production

1998 • 340 citations

Impaired NFATc Translocation and Failure of Th2 Development in Itk-Deficient CD4+ T Cells

1999 • 307 citations

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis

2002 • 293 citations

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1997 • 285 citations

Abnormal differentiation of thymocytes in mice treated with cyclosporin A

1988 • 281 citations

Involvement of p21ras distinguishes positive and negative selection in thymocytes.

1995 • 278 citations

Signaling Life and Death in the Thymus: Timing Is Everything

2003 • 255 citations

Activation of the MKK/ERK Pathway during Somatic Cell Mitosis: Direct Interactions of Active ERK with Kinetochores and Regulation of the Mitotic 3F3/2 Phosphoantigen

1998 • 223 citations

CD3delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage

1997 • 209 citations

A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity

2000 • 203 citations

Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-κB and NFAT

2001 • 189 citations

Defective T cell development and function incalcineurinAβ-deficient mice

2002 • 182 citations

Conversion of an Extracellular Dpp/BMP Morphogen Gradient into an Inverse Transcriptional Gradient

2003 • 181 citations

NFATc2-Mediated Repression of Cyclin-Dependent Kinase 4 Expression

2002 • 171 citations

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency

2001 • 165 citations

Structural Basis of 2C TCR Allorecognition of H-2Ld Peptide Complexes

1998 • 160 citations

Regulatory Principles of Developmental Signaling

2002 • 155 citations

T cell responses in calcineurin A alpha-deficient mice.

1996 • 149 citations

Essential Role of the Pre-T Cell Receptor in Allelic Exclusion of the T Cell Receptor β Locus

1997 • 146 citations

CD3δ couples T-cell receptor signalling to ERK activation and thymocyte positive selection

2000 • 137 citations

Tec Family Kinases Modulate Thresholds for Thymocyte Development and Selection

2000 • 131 citations

Positive Selection Through a Motif in the αβ T Cell Receptor

1998 • 111 citations

Evolutionary relationships among Rel domains indicate functional diversification by recombination

2001 • 103 citations

Natural and Engineered Disorders of Lymphocyte Development

1998 • 102 citations

T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection.

1995 • 97 citations

Requirement for MAPK Activation for Normal Mitotic Progression in Xenopus Egg Extracts

1998 • 90 citations

Raf regulates positive selection

1996 • 90 citations

Thymic selection and cell division.

1995 • 83 citations

In irradiation chimeras, K or D regions of the chimeric host, not of the donor lymphocytes, determine immune responsiveness of antiviral cytotoxic T cells

1978 • 62 citations

Stimulation with specific antigen can block superantigen-mediated deletion of T cells in vivo.

1994 • 55 citations

A role for calcium influx in setting the threshold for CD4+CD8+ thymocyte negative selection.

1996 • 44 citations

Cyclosporin A sensitivity of the NF-χB site of the IL2Rα promoter in untransformed murine T cells

1994 • 44 citations

Molecular Mechanisms of Immunological Self-Recognition

1993 • 43 citations

Effects of a Constitutively Active Form of Calcineurin on T Cell Activation and Thymic Selection

2000 • 40 citations

An Analysis of T Cell Receptor–Ligand Interaction Using a Transgenic Antigen Model for T Cell Tolerance and T Cell Receptor Mutagenesis

1993 • 34 citations

The influence of FK-506 on the thymus: an immunophenotypic and structural analysis.

1990 • 31 citations

DISRUPTION OF T CELL DEVELOPMENT AND REPERTOIRE SELECTION BY CALCINEURIN INHIBITION IN VIVO

1994 • 25 citations