Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC

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Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

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The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation.

1991 • 345 citations

Thymic nurse cells—Ia-bearing epithelium involved in T-lymphocyte differentiation?

1980 • 269 citations

The Influence of Thymus H-2 Antigens on the Specificity of Maturing Killer and Helper Cells

1978 • 257 citations

T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides

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Functional analysis of T lymphocyte subsets in antiviral host defense.

1987 • 237 citations

The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors.

1996 • 225 citations

Thymus medulla consisting of epithelial islets each derived from a single progenitor

2001 • 211 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

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THE MAMMALIAN CELL-VIRUS RELATIONSHIP

1959 • 176 citations

Ovarian teratomas in mice are derived from oocytes that have completed the first meiotic division

1977 • 167 citations

T-cell specificity for H–2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells

1980 • 153 citations

Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts.

1980 • 139 citations

Impairment and delay of neutralizing antiviral antibody responses by virus-specific cytotoxic T cells.

1993 • 134 citations

Inefficient positive selection of T cells directed by haematopoietic cells

1992 • 132 citations

Nude Mice in Immunology

2015 • 114 citations

In a fully H-2 incompatible chimera, T cells of donor origin can respond to minor histocompatibility antigens in association with either donor or host H-2 type.

1978 • 108 citations

Positive selection of T-lymphocytes induced by intrathymic injection of a thymic epithelial cell line

1992 • 103 citations

Positive selection of T lymphocytes on fibroblasts

1993 • 92 citations

A cell line that can induce thymocyte positive selection

1992 • 91 citations

Formalin inactivation of vesicular stomatitis virus impairs T-cell- but not T-help-independent B-cell responses

1993 • 89 citations

Antibody mediated suppression of secondary IgM response in nude mice against vesicular stomatitis virus.

1986 • 84 citations

Positive selection of CD4+T cells by TCR ligation without aggregation even in the absence of MHC

1994 • 83 citations

On the role of thymic epithelium vs. bone marrow-derived cells in repertoire selection of T cells

1999 • 83 citations

Correlation of T Cell Independence of Antibody Responses with Antigen Dose Reaching Secondary Lymphoid Organs: Implications for Splenectomized Patients and Vaccine Design

2000 • 82 citations

Vaccinia-specific cytotoxic T-cell responses in the context of H-2 antigens not encountered in thymus may reflect aberrant recognition of a virus-H-2 complex.

1979 • 80 citations

Fibroblasts can induce thymocyte positive selection in vivo.

1993 • 73 citations

Why Positive Selection?

1993 • 52 citations

Thymus rudiment of the athymic nude mouse

1975 • 40 citations

Extrathymic positive selection of αβ T-cell precursors in nude mice

1992 • 36 citations

Selection of restriction specificities of virus-specific cytotoxic T cells in the thymus: no evidence for a crucial role of antigen-presenting cells.

1982 • 33 citations

T cell‐mediated cytotoxic immune responsiveness of chimeric mice bearing a thymus graft fully allogeneic to the graft of lymphoid stem cells

1980 • 31 citations

Experimentation and thymic selection.

1988 • 19 citations

Thymus-like lymph mode in nude mice

1975 • 10 citations