Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells

1998 • 890 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

Lymphocyte Trafficking and Regional Immunity

1999 • 686 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Receptor clustering as a cellular mechanism to control sensitivity

1998 • 617 citations

Selective Events in T Cell Development

1994 • 486 citations

A weak signal for strong responses: interferon-alpha/beta revisited

2001 • 471 citations

THE DYNAMICS OF T CELL RECEPTOR SIGNALING: Complex Orchestration and the Key Roles of Tempo and Cooperation

1999 • 439 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Fidelity of T Cell Activation Through Multistep T Cell Receptor ζ Phosphorylation

1998 • 338 citations

Costimulation and endogenous MHC ligands contribute to T cell recognition

2001 • 302 citations

Inter-receptor communication through arrays of bacterial chemoreceptors

2002 • 251 citations

The Protection: The Unit of Humoral Immunity Selected by Evolution

1990 • 236 citations

Single Cell Analysis Reveals Regulated Hierarchical T Cell Antigen Receptor Signaling Thresholds and Intraclonal Heterogeneity for Individual Cytokine Responses of CD4+ T Cells

1997 • 222 citations

Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cellbound Ia antigens as targets of immunoregulatory T cells.

1984 • 190 citations

Impairment of immunological memory in the absence of MHC despite survival of memory T cells

2002 • 181 citations

Sensory Adaptation in Naive Peripheral CD4 T Cells

2001 • 163 citations

Tetracycline-controllable Selection of CD4+ T Cells: Half-Life and Survival Signals in the Absence of Major Histocompatibility Complex Class II Molecules

2000 • 158 citations

Relationships Among TCR Ligand Potency, Thresholds for Effector Function Elicitation, and the Quality of Early Signaling Events in Human T Cells

1998 • 157 citations

CD4+ T cell survival is not directly linked to self-MHC–induced TCR signaling

2000 • 156 citations

Absence of Junctional Glutamate Receptor Clusters in Drosophila Mutants Lacking Spontaneous Transmitter Release

2001 • 116 citations

Partially Phosphorylated T Cell Receptor ζ Molecules Can Inhibit T Cell Activation

1999 • 113 citations

Cross-Antagonism of a T Cell Clone Expressing Two Distinct T Cell Receptors

1999 • 108 citations

Single-cell analysis of signal transduction in CD4 T cells stimulated by antigenin vivo

2001 • 78 citations

Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages.

1993 • 62 citations

Interaction of the T cell receptor with bacterial superantigens

1993 • 25 citations

Supra-Agonist Peptides Enhance the Reactivation of Memory CTL Responses

2000 • 24 citations