IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Interleukin-10

1993 • 1,820 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

"Infectious" Transplantation Tolerance

1993 • 890 citations

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1984 • 884 citations

Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells.

1982 • 807 citations

The Role of T-Cell Costimulatory Activation Pathways in Transplant Rejection

1998 • 585 citations

Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection.

1990 • 561 citations

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1995 • 532 citations

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.

1993 • 471 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.

1994 • 413 citations

OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.

1990 • 399 citations

Strategies of Anti‐Cytokine Monoclonal Antibody Development: Immunoassay of IL‐10 and IL‐5 in Clinical Samples

1992 • 384 citations

A functional dichotomy in CD4+ T lymphocytes

1988 • 369 citations

Direct and indirect recognition: the role of MHC antigens in graft rejection

1999 • 347 citations

Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action.

1990 • 302 citations

HEART ALLOGRAFTS IN MURINE SYSTEMS

1992 • 299 citations

Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function

1991 • 286 citations

Human allograft acceptance is associated with immune regulation

2000 • 261 citations

Generation and decay of the immune response to a progressive fibrosarcoma. I. Ly-1+2- suppressor T cells down-regulate the generation of Ly-1-2+ effector T cells.

1984 • 249 citations

A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines

1989 • 237 citations

Functional and ontogenetic analysis of murine CD45Rhi and CD45Rlo CD4+ T cells.

1990 • 236 citations

HOW DO MONOCLONAL ANTIBODIES INDUCE TOLERANCE? A Role for Infectious Tolerance?

1998 • 223 citations

Retrovirus-mediated transfer of viral IL-10 gene prolongs murine cardiac allograft survival.

1996 • 191 citations

MICROCHIMERISM LINKED TO CYTOTOXIC T LYMPHOCYTE FUNCTIONAL UNRESPONSIVENESS (CLONAL ANERGY) IN A TOLERANT RENAL TRANSPLANT RECIPIENT

1995 • 186 citations

Subsets of CD4⁺ T Cells and their Roles in the Induction and Prevention of Autoimmunity

1991 • 174 citations

Mechanisms in CD4 antibody‐mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells

1994 • 167 citations

Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. Mediation of specific suppression by T helper/inducer cells.

1985 • 163 citations

A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance.

1998 • 158 citations

MICROCHIMERISM LINKED TO CYTOTOXIC T LYMPHOCYTE FUNCTIONAL UNRESPONSIVENESS (CLONAL ANERGY) IN A TOLERANT RENAL TRANSPLANT RECIPIENT

1995 • 156 citations

INDUCTION OF TRANSPLANTATION TOLERANCE IN ADULTS USING DONOR ANTIGEN AND ANTI-CD4 MONOCLONAL ANTIBODY

1992 • 153 citations

T cell regulation in adult transplantation tolerance.

1996 • 144 citations

Phenotypic and functional heterogeneity of CD4+ T cells

1988 • 142 citations

Transplantation tolerance induced by antigen pretreatment and depleting anti‐CD4 antibody depends on CD4⁺ T cell regulation during the induction phase of the response

1995 • 134 citations

Interleukin 10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures

1992 • 133 citations

Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4.

1997 • 129 citations

Type 2 helper T cell-type cytokines and the development of "infectious" tolerance in rat cardiac allograft recipients.

1997 • 119 citations

SYSTEMIC ADMINISTRATION OF CELLULAR INTERLEUKIN-10 CAN EXACERBATE CARDIAC ALLOGRAFT REJECTION IN MICE1,2

1996 • 114 citations

EVIDENCE THAT THE CONTINUED PRESENCE OF THE ORGAN GRAFT AND NOT PERIPHERAL DONOR MICROCHIMERISM IS ESSENTIAL FOR MAINTENANCE OF TOLERANCE TO ALLOANTIGEN IN VIVO IN ANTI-CD4 TREATED RECIPIENTS1,2

1996 • 113 citations

TRANSFUSION OF POLARIZED TH2-LIKE CELL POPULATIONS INTO SCID MOUSE CARDIAC ALLOGRAFT RECIPIENTS RESULTS IN ACUTE ALLOGRAFT REJECTION1,2

1996 • 107 citations

Anti-CD4 mediates clonal anergy during transplantation tolerance induction.

1991 • 104 citations

INTERLEUKIN-10 DOSE-DEPENDENT REGULATION OF CD4+ AND CD8+ T CELL-MEDIATED GRAFT-VERSUS-HOST DISEASE1

1998 • 102 citations

CRITICAL ROLE OF INTERLEUKIN 4 IN THE INDUCTION OF NEONATAL TRANSPLANTATION TOLERANCE

1995 • 96 citations

Evidence for Immune Regulation in the Induction of Transplantation Tolerance: A Conditional but Limited Role for IL-4

1999 • 86 citations

Human T cell subsets

1987 • 85 citations

CD4+ CD45RB Low-Density Cells from Untreated Mice Prevent Acute Allograft Rejection

1999 • 75 citations

Anti-CD4 Monoclonal Antibody-Induced Tolerance to MHC-Incompatible Cardiac Allografts Maintained by CD4+ Suppressor T Cells That Are Not Dependent upon IL-4

1998 • 74 citations

Evidence for involvement of clonal anergy in MHC class I and class II disparate skin allograft tolerance after the termination of intrathymic clonal deletion.

1990 • 66 citations

INTERLEUKIN-10 AND POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER AFTER KIDNEY TRANSPLANTATION1

1999 • 57 citations

CD4+CD25+ CELLS REGULATE CD8 CELL ANERGY IN NEONATAL TOLERANT MICE1,2

1999 • 55 citations

INDUCTION OF OPERATIONAL TOLERANCE BY RANDOM BLOOD TRANSFUSION COMBINED WITH ANTI-CD4 ANTIBODY THERAPY

1994 • 50 citations

TRANSFORMING GROWTH FACTOR-?? AND INTERLEUKIN-10 SUBVERT ALLOREACTIVE DELAYED TYPE HYPERSENSITIVITY IN CARDIAC ALLOGRAFT ACCEPTOR MICE1

2000 • 45 citations

Regulatory T cells in thymic epithelium‐induced tolerance. I. Suppression of mature peripheral non‐tolerant T cells

1995 • 38 citations

SPECIFIC UNRESPONSIVENESS IN RATS WITH PROLONGED CARDIAC ALLOGRAFT SURVIVAL AFTER TREATMENT WITH CYCLOSPORINE

1993 • 33 citations

LYMPHOKINE PRODUCTION BY MLR-REACTIVE REACTION LYMPHOCYTES OBTAINED FROM NORMAL MICE AND MICE RENDERED TOLERANT OF CLASS II MHC ANTIGENS

1989 • 32 citations

INTERLEUKIN 12 IN COMBINATION WITH ANTMNTERLEUKIN 10 REVERSES GRAFT PROLONGATION AFTER PORTAL VENOUS IMMUNIZATION

1995 • 31 citations

MEDIATION OF ANTIGEN-INDUCED SUPPRESSION OF RENAL ALLOGRAFT REJECTION BY A CD4 (W3/25+) T CELL

1989 • 21 citations

CD45RC+ CD4 T CELL SUBSETS ARE MAINTAINED IN AN UNRESPONSIVE STATE BY THE PERSISTENCE OF TRANSFUSION-DERIVED ALLOANTIGEN

1995 • 20 citations

EFFECT OF ONE-HLA-HAPLOTYPE-MATCHED AND HLA-MISMATCHED BLOOD TRANSFUSIONS ON RECIPIENT T LYMPHOCYTE ALLOREPERTOIRES1

1997 • 19 citations

CD45RC+ CD4 T CELL SUBSETS ARE MAINTAINED IN AN UNRESPONSIVE STATE BY THE PERSISTENCE OF TRANSFUSION-DERIVED ALLOANTIGEN

1995 • 16 citations

Progressive changes in CD45RB phenotype and lymphokine production by murine CD4+ T cells after alloantigen exposure.

1992 • 16 citations

Cellular mechanisms that maintain neonatally-induced tolerance of class II alloantigens. Evidence that factor-mediated suppression silences cytotoxic T cell activity.

1994 • 13 citations

Absence of suppressor cells from rats bearing passively enhanced kidney allografts

1977 • 11 citations