The role of dendritic cells in T cell selection and survival

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

Negative selection of lymphocytes

1994 • 810 citations

Positive Selection of Thymocytes

1995 • 604 citations

Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo

1997 • 459 citations

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

1997 • 419 citations

Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

1997 • 402 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

Targeted disruption of the MHC class II Aa gene in C57BL/6 mice

1993 • 377 citations

The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells.

1989 • 331 citations

The effect of thymus environment on T cell development and tolerance

1988 • 330 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

Compartmentalization of MHC class II gene expression in transgenic mice

1988 • 201 citations

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

1994 • 197 citations

Requirement for Cotolerogenic Gene Products in the Clonal Deletion of I-E Reactive T Cells

1990 • 193 citations

Transgenic mice selectively lacking MHC class II (I-E) antigen expression on B cells: An in vivo approach to investigate la gene function

1987 • 134 citations

Inefficient positive selection of T cells directed by haematopoietic cells

1992 • 132 citations

Requirement of dendritic cells and B cells in the clonal deletion of Mls-reactive T cells in the thymus.

1991 • 113 citations

Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor.

1995 • 104 citations

Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice.

1993 • 92 citations

The thymic compartment responsible for positive selection of CD4⁺ T cells

1992 • 89 citations

Clonal deletion of V beta 5+ T cells by transgenic I-E restricted to thymic medullary epithelium.

1993 • 76 citations

Class I and class II MHC gene products differentially affect the fate of V beta 5 bearing thymocytes.

1990 • 44 citations

Bone marrow-derived cells fail to induce positive selection in thymus reaggregation cultures.

1996 • 36 citations

Driving Gene Expression Specifically in Dendritic Cells

1997 • 21 citations

Targeted expression of MHC class II genes to dendritic cells in vivo

1997 • 4 citations