Cell Death Control in Lymphocytes

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Caspases: Enemies Within

1998 • 6,923 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

The Fas Death Factor

1995 • 4,070 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

1999 • 1,927 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

1984 • 1,761 citations

The Receptor for the Cytotoxic Ligand TRAIL

1997 • 1,755 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 • 1,719 citations

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

1997 • 1,694 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1998 • 1,651 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

1997 • 1,506 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

Apoptosis control by death and decoy receptors

1999 • 1,296 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

1993 • 1,267 citations

Caspase-3-Generated Fragment of Gelsolin: Effector of Morphological Change in Apoptosis

1997 • 1,233 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

1998 • 1,224 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Osteoprotegerin Is a Receptor for the Cytotoxic Ligand TRAIL

1998 • 1,177 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1998 • 1,154 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

1998 • 1,143 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Ca ²⁺ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD

1999 • 1,136 citations

Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

1998 • 1,132 citations

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL

1997 • 1,119 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

1999 • 1,045 citations

An Induced Proximity Model for Caspase-8 Activation

1998 • 1,030 citations

Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death

1999 • 1,024 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1985 • 972 citations

Apo2L/TRAIL-Dependent Recruitment of Endogenous FADD and Caspase-8 to Death Receptors 4 and 5

2000 • 968 citations

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.

1993 • 959 citations

Fas ligand mediates activation-induced cell death in human T lymphocytes.

1995 • 949 citations

Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor

1997 • 937 citations

BID: a novel BH3 domain-only death agonist.

1996 • 921 citations

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

1990 • 910 citations

Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development

1998 • 894 citations

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

1998 • 893 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1998 • 872 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

1993 • 857 citations

The Novel Receptor TRAIL-R4 Induces NF-κB and Protects against TRAIL-Mediated Apoptosis, yet Retains an Incomplete Death Domain

1997 • 829 citations

The Role of c-FLIP in Modulation of CD95-induced Apoptosis

1999 • 823 citations

FADD/MORT1 and Caspase-8 Are Recruited to TRAIL Receptors 1 and 2 and Are Essential for Apoptosis Mediated by TRAIL Receptor 2

2000 • 792 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity

1998 • 789 citations

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

1998 • 781 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

Inactivation of Bcl-2 by phosphorylation.

1995 • 744 citations

The SCID Mouse Mutant: Definition, Characterization, and Potential Uses

1991 • 743 citations

Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2

1997 • 742 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 • 731 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1998 • 704 citations

Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway

1997 • 685 citations

TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB

1997 • 683 citations

Downregulation of Fas ligand by shedding

1998 • 681 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95

1996 • 653 citations

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

2000 • 651 citations

A novel receptor for Apo2L/TRAIL contains a truncated death domain

1997 • 650 citations

Biochemical Mechanisms of IL-2–Regulated Fas-Mediated T Cell Apoptosis

1998 • 644 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

Phosphorylation and Inactivation of BAD by Mitochondria-Anchored Protein Kinase A

1999 • 635 citations

Cloning and Characterization of TRAIL-R3, a Novel Member of the Emerging TRAIL Receptor Family

1997 • 634 citations

Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II

1999 • 631 citations

The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9

1998 • 628 citations

Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

1992 • 608 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

1995 • 596 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

Positive Selection of Natural Autoreactive B Cells

1999 • 574 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Positive selection of lymphocytes

1994 • 563 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

RAIDD is a new 'death' adaptor molecule

1997 • 547 citations

Bcl-2 Phosphorylation Required for Anti-apoptosis Function

1997 • 540 citations

Bcl-X _L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1998 • 534 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

Fas transduces activation signals in normal human T lymphocytes.

1993 • 521 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1996 • 519 citations

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

1995 • 514 citations

Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death

1993 • 514 citations

Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development

2000 • 509 citations

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

1998 • 504 citations

Membrane Fas Ligand Kills Human Peripheral Blood T Lymphocytes, and Soluble Fas Ligand Blocks the Killing

1997 • 503 citations

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

1997 • 503 citations

Cytochrome c and dATP-mediated Oligomerization of Apaf-1 Is a Prerequisite for Procaspase-9 Activation

1999 • 502 citations

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

1995 • 501 citations

Genetics of programmed cell death in C. elegans: past, present and future

1998 • 486 citations

Caspase-3 Is Required for α-Fodrin Cleavage but Dispensable for Cleavage of Other Death Substrates in Apoptosis

1998 • 484 citations

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

1995 • 470 citations

The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A

1996 • 466 citations

TRAF2 Is Essential for JNK but Not NF-κB Activation and Regulates Lymphocyte Proliferation and Survival

1997 • 449 citations

RETRACTED: Uncoupling IL-2 Signals that Regulate T Cell Proliferation, Survival, and Fas-Mediated Activation-Induced Cell Death

1999 • 443 citations

Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.

1995 • 431 citations

Control points in early T-cell development

1993 • 429 citations

The Distinct Roles of TRAF2 and RIP in IKK Activation by TNF-R1

2000 • 429 citations

Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells

1995 • 426 citations

Autoproteolytic Activation of Pro-Caspases by Oligomerization

1998 • 424 citations

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

1997 • 419 citations

Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation

1999 • 418 citations

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

1996 • 415 citations

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1999 • 410 citations

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

1993 • 410 citations

Prevention of Constitutive TNF Receptor 1 Signaling by Silencer of Death Domains

1999 • 408 citations

Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor

1996 • 405 citations

Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice

1993 • 402 citations

Casper Is a FADD- and Caspase-Related Inducer of Apoptosis

1997 • 398 citations

Bcl-2 and Bax function independently to regulate cell death

1997 • 397 citations

Role for Bcl-x_Las an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis

1997 • 397 citations

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia.

1994 • 396 citations

Cytokine-induced survival of activated T cellsin vitroandin vivo

1998 • 395 citations

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.

1995 • 393 citations

Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

1999 • 385 citations

Different Nuclear Signals Are Activated by the B Cell Receptor during Positive Versus Negative Signaling

1997 • 383 citations

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-XL

1997 • 381 citations

I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

1997 • 372 citations

A Newly Identified Member of Tumor Necrosis Factor Receptor Superfamily (TR6) Suppresses LIGHT-mediated Apoptosis

1999 • 370 citations

The Roles of Costimulation and Fas in T Cell Apoptosis and Peripheral Tolerance

1996 • 367 citations

Membrane Oligomerization and Cleavage Activates the Caspase-8 (FLICE/MACHα1) Death Signal

1998 • 366 citations

The Kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

1998 • 360 citations

Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

1997 • 357 citations

Interaction and Regulation of Subcellular Localization of CED-4 by CED-9

1997 • 345 citations

FLICE Induced Apoptosis in a Cell-free System

1997 • 343 citations

FLAME-1, a Novel FADD-like Anti-apoptotic Molecule That Regulates Fas/TNFR1-induced Apoptosis

1997 • 339 citations

The Earliest T Lineage–Committed Cells Depend on IL-7 for Bcl-2 Expression and Normal Cell Cycle Progression

1997 • 338 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

A death-domain-containing receptor that mediates apoptosis

1996 • 333 citations

TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL

1997 • 331 citations

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.

1996 • 331 citations

TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling

1998 • 327 citations

The Roles of Fas/APO-1 (CD95) and TNF in Antigen-Induced Programmed Cell Death in T Cell Receptor Transgenic Mice

1996 • 325 citations

CASH, a Novel Caspase Homologue with Death Effector Domains

1997 • 323 citations

Cell death attenuation by `Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex

1998 • 318 citations

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis

1997 • 316 citations

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

1996 • 316 citations

Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

1997 • 315 citations

bcl-w, a novel member of the bcl-2 family, promotes cell survival.

1996 • 309 citations

Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes.

1994 • 305 citations

Interaction between the C. elegans cell-death regulators CED-9 and CED-4

1997 • 304 citations

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x_L

1999 • 295 citations

Identification of a novel regulatory domain in Bcl-xL and Bcl-2

1997 • 287 citations

Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes.

1993 • 286 citations

Death by a thousand cuts: an ever increasing list of caspase substrates

1998 • 286 citations

Induction of cell death by tumour necrosis factor (TNF) receptor 2,CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF

1999 • 286 citations

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

1996 • 280 citations

Identification and functional characterization of DR6, a novel death domain‐containing TNF receptor

1998 • 275 citations

Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77)

1995 • 273 citations

TRAMP, a Novel Apoptosis-Mediating Receptor with Sequence Homology to Tumor Necrosis Factor Receptor 1 and Fas(Apo-1/CD95)

1997 • 268 citations

Fas-associated Death Domain Protein Interleukin-1β-converting Enzyme 2 (FLICE2), an ICE/Ced-3 Homologue, Is Proximally Involved in CD95- and p55-mediated Death Signaling

1997 • 256 citations

WD-40 Repeat Region Regulates Apaf-1 Self-association and Procaspase-9 Activation

1998 • 252 citations

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control Points

1994 • 252 citations

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.

1997 • 252 citations

Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-κB

1996 • 251 citations

Bclx regulates the survival of double-positive thymocytes.

1995 • 249 citations

Bcl-2, Bcl-xL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death

1997 • 248 citations

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.

1993 • 247 citations

Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.

1996 • 247 citations

Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice.

1995 • 245 citations

A Role for FADD in T Cell Activation and Development

1998 • 241 citations

The expression of Vpre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice

1994 • 238 citations

MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclX _L and initiates cell death

1997 • 238 citations

CAR1, a TNFR–Related Protein, Is a Cellular Receptor for Cytopathic Avian Leukosis–Sarcoma Viruses and Mediates Apoptosis

1996 • 236 citations

Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities.

1996 • 236 citations

Mutations in the Fas Antigen in Patients With Multiple Myeloma

1997 • 228 citations

CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival

1997 • 224 citations

Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice

1997 • 220 citations

RETRACTED: The Fas/Fas Ligand Pathway and Bcl-2 Regulate T Cell Responses to Model Self and Foreign Antigens

1998 • 216 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

LARD: A new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing

1997 • 211 citations

CD3ε-mediated signals rescue the development of CD4⁺CD8⁺ thymocytes in RAG-2^−/− mice in the absence of TCR β chain expression

1994 • 205 citations

Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo

1995 • 201 citations

The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane

1992 • 201 citations

Induction of Apoptosis by Human Nbk/Bik, a BH3-Containing Protein That Interacts with E1B 19K

1996 • 201 citations

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody.

1995 • 197 citations

Pro-Thymocyte Expansion by c-kit and the Common Cytokine Receptor γ Chain Is Essential for Repertoire Formation

1997 • 195 citations

CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45

1998 • 194 citations

Activation of the CPP32 Apoptotic Protease by Distinct Signaling Pathways with Differential Sensitivity to Bcl-xL

1996 • 190 citations

B cell development: signal transduction by antigen receptors and their surrogates

1999 • 186 citations

Mutations in the Fas Antigen in Patients With Multiple Myeloma

1997 • 183 citations

Spontaneous Development of Plasmacytoid Tumors in Mice with Defective Fas–Fas Ligand Interactions

1998 • 181 citations

bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice.

1996 • 178 citations

Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice.

1995 • 178 citations

Boo, a novel negative regulator of cell death, interacts with Apaf-1

1999 • 177 citations

CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.

1996 • 174 citations

Mutations in the p53 and SCID genes cooperate in tumorigenesis.

1996 • 173 citations

The Peripheral Deletion of Autoreactive CD8+ T Cells Induced by Cross-presentation of Self-antigens Involves Signaling through CD95 (Fas, Apo-1)

1998 • 173 citations

Diva, a Bcl-2 Homologue that Binds Directly to Apaf-1 and Induces BH3-independent Cell Death

1998 • 170 citations

Kinetics of T cell receptor β, γ, and δ rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44⁺CD25⁺Pro-T thymocytes

1998 • 169 citations

Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced

1997 • 168 citations

E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells.

1993 • 162 citations

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.

1996 • 161 citations

Molecular Cloning of a Novel Polypeptide, DP5, Induced during Programmed Neuronal Death

1997 • 158 citations

Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants

1998 • 157 citations

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

1999 • 157 citations

Bcl-2 expression promotes B- but not T-lymphoid development in scid mice

1994 • 157 citations

CD3 components at the surface of pro‐T cells can mediate pre‐T cell development in vivo

1994 • 156 citations

Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I.

1996 • 156 citations

Effects of the lpr mutation on elimination and inactivation of self-reactive B cells.

1994 • 156 citations

Tumor necrosis factor (TNF) receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1

1998 • 149 citations

An essential role for gp39, the ligand for CD40, in thymic selection.

1995 • 148 citations

Positive and negative selection of T cells in T-cellreceptor transgenic mice expressing a bcl-2 transgene.

1994 • 147 citations

Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells

1993 • 146 citations

Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction

1998 • 144 citations

FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

2000 • 142 citations

Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL.

1998 • 142 citations

bcl-2 proto-oncogene expression during human T cell development. Evidence for biphasic regulation.

1993 • 140 citations

Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo

1995 • 134 citations

FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen.

1995 • 134 citations

Expression and function of mouse Fas antigen on immature and mature T cells.

1995 • 133 citations

Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers

1994 • 133 citations

Enforced Bcl-2 Expression Inhibits Antigen-mediated Clonal Elimination of Peripheral B Cells in an Antigen Dose–dependent Manner and Promotes Receptor Editing in Autoreactive, Immature B Cells

1997 • 132 citations

Interaction and Regulation of the Caenorhabditis elegans Death Protease CED-3 by CED-4 and CED-9

1997 • 130 citations

Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice

1992 • 130 citations

Inhibition of Fas-mediated apoptosis by the B cell antigen receptor through c-FLIP

2000 • 128 citations

Functional Roles of Fas and Bcl-2-Regulated Apoptosis of T Lymphocytes

1998 • 126 citations

The Role of Environmental Antigens in the Spontaneous Development of Autoimmunity in MRL-lprMice

1999 • 125 citations

Studies of T cell deletion and T cell anergy following in vivo administration of SEB to normal and lupus-prone mice.

1993 • 125 citations

Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo

1996 • 124 citations

Pre-TCR Signaling and Inactivation of p53 Induces Crucial Cell Survival Pathways in Pre-T Cells

1999 • 122 citations

Self-Reactive B Lymphocytes Overexpressing Bcl-xL Escape Negative Selection and Are Tolerized by Clonal Anergy and Receptor Editing

1998 • 120 citations

CED-4 induces chromatin condensation in Schizosaccharomyces pombe and is inhibited by direct physical association with CED-9

1997 • 120 citations

Frequent Aberrant Immunoglobulin Gene Rearrangements in Pro-B Cells Revealed by a bcl-x Transgene

1996 • 120 citations

Mechanisms and control of programmed cell death in invertebrates

1998 • 119 citations

Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis.

1996 • 117 citations

Apoptosis of mouse naive T cells induced by recombinant soluble Fas ligand and activation-induced resistance to Fas ligand.

1996 • 116 citations

The turnover of B-cell populations

1993 • 115 citations

Blk, a BH3-containing Mouse Protein That Interacts with Bcl-2 and Bcl-xL, Is a Potent Death Agonist

1998 • 113 citations

Regulation of apoptosis and T cell activation by Fas-specific mAb

1994 • 107 citations

p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.

1996 • 106 citations

Restoration of Thymopoiesis in pTα−/− Mice by Anti-CD3ε Antibody Treatment or with Transgenes Encoding Activated Lck or Tailless pTα

1997 • 106 citations

p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes.

1996 • 104 citations

Cutting Edge: Lymphocyte Inhibitor of TRAIL (TNF-Related Apoptosis-Inducing Ligand): A New Receptor Protecting Lymphocytes from the Death Ligand TRAIL

1998 • 104 citations

A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice.

1996 • 104 citations

In Vivo Evidence That Caspase-3 Is Required for Fas-Mediated Apoptosis of Hepatocytes

1999 • 103 citations

Repression of B7.2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD4+ T Cells

1998 • 96 citations

T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection

1997 • 88 citations

TNF Receptor-Deficient Mice Reveal Striking Differences Between Several Models of Thymocyte Negative Selection

1998 • 84 citations

Role of bcl-2 in the Development of Lymphoid Cells From the Hematopoietic Stem Cell

1997 • 83 citations

Direct physical interaction between the Caenorhabditis elegans ‘death proteins’ CED‐3 and CED‐4

1997 • 83 citations

Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection

1998 • 81 citations

T cell receptor‐negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway

1990 • 79 citations

The large subunit of replication factor C is a substrate for caspase-3 invitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis

1997 • 76 citations

The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus.

1994 • 76 citations

Homeostatic regulation of CD8⁺ T cells after antigen challenge in the absence of Fas (CD95)

1996 • 70 citations

Overexpression of Bcl-2 does not rescue impaired B lymphopoiesis in IL- 7 receptor-deficient mice but can enhance survival of mature B cells

1998 • 70 citations

Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor

1999 • 70 citations

Analysis of central B cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenes.

1996 • 68 citations

Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo

1998 • 66 citations

Lack of Release of Cytochrome c from Mitochondria into Cytosol Early in the Course of Fas-mediated Apoptosis of Jurkat Cells

1998 • 66 citations

V(D)J recombination is not required for the development of lymphoma in p53-deficient mice.

1998 • 63 citations

BCL-XL-regulated apoptosis in T cell development

1997 • 63 citations

Constitutive Bcl-2 Expression during Immunoglobulin Heavy Chain–Promoted B Cell Differentiation Expands Novel Precursor B Cells

1997 • 57 citations

bcl-2 transgenic Lpr mice show profound enhancement of lymphadenopathy.

1995 • 53 citations

Dying like Flies

1998 • 51 citations

Efficient Peripheral Clonal Elimination of B Lymphocytes in MRL/lpr Mice Bearing Autoantibody Transgenes

1998 • 47 citations

C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death

1999 • 47 citations

Collaboration of PIM-1 and BCL-2 in Lymphomagenesis

1992 • 46 citations

Normal thymic selection, superantigen-induced deletion and Fas-mediated apoptosis of T cells in IL-2 receptor beta chain-deficient mice

1997 • 45 citations

Correlation of T cell receptor gene rearrangements to T cell surface antigen expression and to serum immunoglobulin level inscid mice

1987 • 41 citations

Continued differentiation during B lymphopoiesis requires signals in addition to cell survival

1997 • 38 citations

Bcl-2 prevents activation of CPP32 cysteine protease and cleavage of poly (ADP-ribose) polymerase and U1-70 kD proteins in staurosporine-mediated apoptosis

1997 • 34 citations

Exploring cell death mechanisms by analyzing signaling cascades of the TNF/NGF receptor family.

1996 • 31 citations

Inhibition of Apoptosis and Augmentation of Lymphoproliferation inbcl-2Transgenic Fas/Fas Ligand-Defective Mice

1996 • 25 citations

Fas (CD95)-independent regulation of immune responses by antigen-specific CD4^—CD8⁺ T cells

1996 • 24 citations

The Fas-deficient SCID mouse exhibits the development of T cells in the thymus.

1997 • 13 citations

Effect of a bcl-2 transgene on production and localization of precursor B cells in mouse bone marrow.

1998 • 11 citations