A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice.

The Fas Death Factor

1995 • 4,070 citations

Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

1978 • 1,619 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Loss of HLA class I antigens by melanoma cells: molecular mechanisms, functional significance and clinial relevance

1995 • 478 citations

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

1995 • 470 citations

Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells

1995 • 426 citations

The Roles of Costimulation and Fas in T Cell Apoptosis and Peripheral Tolerance

1996 • 367 citations

Abnormalities induced by the mutant gene Ipr: expansion of a unique lymphocyte subset.

1982 • 295 citations

Loss of the chromosomal region 10q23-25 in prostate cancer.

1995 • 238 citations

Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells

1994 • 225 citations

Allelic losses on chromosomes 14, 10, and 1 in atypical and malignant meningiomas: a genetic model of meningioma progression.

1995 • 213 citations

Allelic loss of sequences from the long arm of chromosome 10 and replication errors in endometrial cancers.

1995 • 181 citations

Murine lupus in the absence of alpha beta T cells.

1996 • 151 citations

Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligand.

1996 • 141 citations

Loss of heterozygosity for 10q22-10qter in malignant melanoma progression.

1994 • 101 citations

Induction of Fas-mediated apoptosis in p53-transfected human colon carcinoma cells.

1995 • 90 citations

Immune Response against Tumors

1994 • 80 citations

A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice

1988 • 75 citations

Expression of Bcl-2 protein and Fas antigen in non-Hodgkin's lymphomas.

1994 • 69 citations

Recurrent abnormalities of chromosome bands 10q23–25 in non‐Hodgkin's lymphoma

1992 • 59 citations

Somatic mutation of human immunoglobulin V genes in the X-linked HyperIgM syndrome.

1995 • 56 citations

The human APO-1 (APT) antigen maps to 10q23, a region that is syntenic with mouse chromosome 19

1992 • 49 citations

Abnormalities induced by the mutant gene, lpr. Patterns of disease and expression of murine leukemia viruses in SJL/J mice homozygous and heterozygous for lpr.

1985 • 45 citations

Spontaneous resistance to acute T-cell leukaemias in TCRVγ1.1Jγ4Cγ4 transgenic mice

1995 • 40 citations

T cells with gamma/delta T cell receptors (TCR) of intestinal type are preferentially expanded in TCR-alpha-deficient lpr mice.

1995 • 29 citations

Sm and DNA binding by dual reactive B cells requires distinct VH, V kappa, and VH CDR3 structures.

1995 • 29 citations

Functional significance of the Fas molecule in naive lymphocytes

1996 • 28 citations

HIV-mediated B-lymphocyte activation and lymphomagenesis

1995 • 23 citations