Interaction and Regulation of the Caenorhabditis elegans Death Protease CED-3 by CED-4 and CED-9

The embryonic cell lineage of the nematode Caenorhabditis elegans

1983 • 4,070 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1992 • 889 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

1992 • 608 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death

1992 • 387 citations

Interaction and Regulation of Subcellular Localization of CED-4 by CED-9

1997 • 345 citations

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.

1996 • 331 citations

Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors

1996 • 321 citations

Interaction between the C. elegans cell-death regulators CED-9 and CED-4

1997 • 304 citations

Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities.

1996 • 236 citations

The Genetics of Programmed Cell Death in the Nematode Caenorhabditis elegans

1994 • 195 citations

Bax Can Antagonize Bcl-XL during Etoposide and Cisplatin-induced Cell Death Independently of Its Heterodimerization with Bcl-XL

1996 • 101 citations

Protease Activity of in Vitro Transcribed and Translated Caenorhabditis elegans Cell Death Gene (ced-3) Product

1996 • 44 citations