Caspase-3-Generated Fragment of Gelsolin: Effector of Morphological Change in Apoptosis

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Gene Expression Profiles in Normal and Cancer Cells

1997 • 1,157 citations

A License to Kill

1996 • 649 citations

Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils.

1996 • 574 citations

Chapter 8 Use of Recombinant Adenovirus for Metabolic Engineering of Mammalian Cells

1994 • 571 citations

Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32

1996 • 481 citations

Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain

1986 • 477 citations

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1995 • 467 citations

Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin

1995 • 437 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.

1996 • 331 citations

Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition.

1996 • 298 citations

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

1994 • 290 citations

Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases.

1995 • 265 citations

Systematic identification of mitotic phosphoproteins

1997 • 225 citations

Identification of Actin as a Substrate of ICE and an ICE-like Protease and Involvement of an ICE-like Protease but Not ICE in Vp-16-Induced U937 Apoptosis

1995 • 210 citations

Control of Actin Assembly at Filament Ends

1995 • 202 citations

A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis.

1995 • 194 citations

Identification of critical functional and regulatory domains in gelsolin.

1989 • 194 citations

Gelsolin: a candidate for suppressor of human bladder cancer.

1995 • 191 citations

Rapid acceleration of neutrophil apoptosis by tumor necrosis factor-α

1993 • 149 citations

Nucleotide sequence of pig plasma gelsolin

1988 • 136 citations

The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans.

1993 • 127 citations

Cyclin D3 Sensitizes Tumor Cells to Tumor Necrosis Factor-Induced, c-Myc-Dependent Apoptosis

1996 • 57 citations

キイロショウジョウバエの原腸形成や筋退行変性に関与するflightless-I遺伝子はゲルゾリン様及びにロイシン富有反復ドメインをコードし、Caenor-habdits elegantsとヒトで保存される

1993 • 56 citations

Cloning of Murine Gelsolin and Its Regulation during Differentiation of Embryonal Carcinoma Cells

1989 • 47 citations

FUNCTIONAL GENOMICS: Expression Cloning in the Test Tube

1997 • 46 citations

Role of actin-binding proteins in cytoskeletal dynamics

1991 • 37 citations

Differential effects of gelsolins on tissue culture cells

1990 • 23 citations