Downregulation of Fas ligand by shedding

Apoptosis by Death Factor

1997 • 5,038 citations

The Fas Death Factor

1995 • 4,070 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

1995 • 1,311 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

A role for CD95 ligand in preventing graft rejection

1995 • 1,184 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

Human tumor necrosis factor. Production, purification, and characterization.

1985 • 922 citations

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

1992 • 839 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Fas ligand in human serum

1996 • 682 citations

Expression of the Fas ligand in cells of T cell lineage.

1995 • 659 citations

Expression of the functional soluble form of human fas ligand in activated lymphocytes.

1995 • 656 citations

Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells.

1993 • 643 citations

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1994 • 607 citations

Potential Involvement of Fas and Its Ligand in the Pathogenesis of Hashimoto's Thyroiditis

1997 • 584 citations

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

1994 • 571 citations

The Role of Fas in Autoimmune Diabetes

1997 • 503 citations

A metalloprotease-disintegrin participating in myoblast fusion

1995 • 492 citations

Essential roles of the Fas ligand in the development of hepatitis

1997 • 483 citations

Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover.

1996 • 464 citations

Prevention of Islet Allograft Rejection with Engineered Myoblasts Expressing FasL in Mice

1996 • 456 citations

Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction

1997 • 453 citations

Human Fas ligand: gene structure, chromosomal location and species specificity

1994 • 435 citations

A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact

1990 • 409 citations

ADAM, a Widely Distributed and Developmentally Regulated Gene Family Encoding Membrane Proteins with A̱Ḏisintegrin A̱nd M̱etalloprotease Domain

1995 • 406 citations

Transgenic expression of CD95 ligand on islet β cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts

1997 • 373 citations

Fas-mediated cytotoxicity by freshly isolated natural killer cells.

1995 • 372 citations

Antitumor effect of locally produced CD95 ligand

1997 • 315 citations

A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation

1995 • 252 citations

Requirement of Fas for the Development of Autoimmune Diabetes in Nonobese Diabetic Mice

1997 • 238 citations

Fas-Mediated Apoptosis in Primary Cultured Mouse Hepatocytes

1994 • 202 citations

Lethal effect of recombinant human Fas ligand in mice pretreated with Propionibacterium acnes.

1997 • 163 citations

Human Native Soluble CD40L Is a Biologically Active Trimer, Processed Inside Microsomes

1996 • 117 citations

Continuous internalization of tumor necrosis factor receptors in a human myosarcoma cell line.

1988 • 97 citations

Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor.

1997 • 85 citations

Establishment of apoptosis‐inducing monoclonal antibody 2D1 and 2D1‐resistant variants of human T cell lines

1993 • 30 citations

In vivo activity of tumor necrosis factor (TNF) mutants. Secretory but not membrane-bound TNF mediates the regression of retrovirally transduced murine tumor.

1992 • 24 citations

Cleavage of membrane‐bound CD40 ligand is not required for inducing B cell proliferation and differentiation

1996 • 17 citations