Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x_L

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1997 • 1,305 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

1998 • 1,224 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

1998 • 1,143 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

An Induced Proximity Model for Caspase-8 Activation

1998 • 1,030 citations

Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death

1999 • 1,024 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

1995 • 964 citations

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

1990 • 910 citations

Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development

1998 • 894 citations

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

1998 • 893 citations

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

1997 • 797 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity

1998 • 789 citations

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1998 • 704 citations

Downregulation of Fas ligand by shedding

1998 • 681 citations

RAIDD is a new 'death' adaptor molecule

1997 • 547 citations

Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1996 • 519 citations

APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth

1998 • 505 citations

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

1998 • 504 citations

Activation interferes with the APO-1 pathway in mature human T cells

1993 • 466 citations

Prevention of Constitutive TNF Receptor 1 Signaling by Silencer of Death Domains

1999 • 408 citations

DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement

1992 • 392 citations

Bcl–2 protects from lethal hepatic apoptosis induced by an ant–Fas antibody in mice

1996 • 370 citations

Membrane Oligomerization and Cleavage Activates the Caspase-8 (FLICE/MACHα1) Death Signal

1998 • 366 citations

Bcl-2, Bcl-xL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death

1997 • 248 citations

Fas-Mediated Apoptosis in Primary Cultured Mouse Hepatocytes

1994 • 202 citations

A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection.

1996 • 182 citations

Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma.

1995 • 178 citations

Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice.

1995 • 178 citations

Mice Defective in Two Apoptosis Pathways in the Myeloid Lineage Develop Acute Myeloblastic Leukemia

1998 • 173 citations

Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis.

1998 • 159 citations

Disparate Roles for TNF-α and Fas Ligand in Concanavalin A-Induced Hepatitis

1998 • 150 citations

Analysis of recent thymic emigrants with subse- and maturity-related markers

1990 • 83 citations

Apoptosis abnormalities of splenic lymphocytes in autoimmune lpr and gld mice.

1995 • 59 citations