Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

Basic local alignment search tool

1990 • 87,358 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

1997 • 1,429 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Life, death, and the pursuit of apoptosis.

1996 • 1,333 citations

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

1997 • 1,329 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

BID: a novel BH3 domain-only death agonist.

1996 • 921 citations

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

1995 • 832 citations

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1997 • 648 citations

Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35

1995 • 645 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

1994 • 590 citations

A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

1995 • 491 citations

A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak

1997 • 437 citations

Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.

1995 • 431 citations

Using the two-hybrid system to detect protein-protein interactions

1993 • 414 citations

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-XL

1997 • 381 citations

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1997 • 371 citations

Interaction and Regulation of Subcellular Localization of CED-4 by CED-9

1997 • 345 citations

bcl-w, a novel member of the bcl-2 family, promotes cell survival.

1996 • 309 citations

Interaction between the C. elegans cell-death regulators CED-9 and CED-4

1997 • 304 citations

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine.

1995 • 227 citations

Hormonal Regulation of Granulosa Cell Inhibin Biosynthesis*

1986 • 208 citations

Induction of Apoptosis by Human Nbk/Bik, a BH3-Containing Protein That Interacts with E1B 19K

1996 • 201 citations

Gonadal cell apoptosis.

1996 • 181 citations

Targeted overexpression of Bcl-2 in ovaries of transgenic mice leads to decreased follicle apoptosis, enhanced folliculogenesis, and increased germ cell tumorigenesis.

1996 • 177 citations

Interference of BAD (Bcl-xL/Bcl-2-Associated Death Promoter)-Induced Apoptosis in Mammalian Cells by 14–3-3 Isoforms and P11

1997 • 176 citations

Apoptosis in the human uterine endometrium during the menstrual cycle.

1996 • 171 citations

Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe.

1997 • 160 citations

BHRF1, the Epstein-Barr virus gene with homology to Bc12, is dispensable for B-lymphocyte transformation and virus replication

1991 • 128 citations

Modulation of Cell Death in Yeast by the Bcl-2 Family of Proteins

1997 • 105 citations

Wilms' tumor protein WT1 as an ovarian transcription factor: decreases in expression during follicle development and repression of inhibin-alpha gene promoter.

1995 • 87 citations

p53-independent apoptotic and necrotic cell deaths induced by adenovirus infection: suppression by E1B 19K and Bcl-2 proteins.

1995 • 86 citations

Adenovirus E1B 19-kDa Death Suppressor Protein Interacts with Bax but Not with Bad

1996 • 55 citations

Insights from transgenic mice regarding the role ofbcl-2 in normal and neoplastic lymphoid cells

1994 • 33 citations