Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

The embryonic cell lineage of the nematode Caenorhabditis elegans

1983 • 4,070 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

1977 • 3,432 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

1991 • 3,108 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

1984 • 1,761 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions

1949 • 974 citations

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1985 • 972 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1992 • 889 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

1990 • 622 citations

A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans

1990 • 618 citations

The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death

1990 • 533 citations

Cell Death Mechanisms and the Immune System

1991 • 459 citations

Mutations Affecting Programmed Cell Deaths in the Nematode Caenorhabditis elegans s

1983 • 389 citations

The Caenorhabditis elegans rol-6 gene, which interacts with the sqt-1 collagen gene to determine organismal morphology, encodes a collagen.

1990 • 338 citations

Formation of the first cleavage spindle in nematode embryos

1984 • 307 citations

Temporal and spatial expression patterns of the small heat shock (hsp16) genes in transgenic Caenorhabditis elegans.

1992 • 302 citations

Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing

1992 • 165 citations

Abnormalities of the Immune System Induced by Dysregulated bcl-2 Expression in Transgenic Mice

1990 • 129 citations

Structure, expression, and evolution of a heat shock gene locus in Caenorhabditis elegans that is flanked by repetitive elements.

1986 • 107 citations