The Earliest T Lineage–Committed Cells Depend on IL-7 for Bcl-2 Expression and Normal Cell Cycle Progression

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

Life, death, and the pursuit of apoptosis.

1996 • 1,333 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

An evolutionary perspective on apoptosis

1994 • 758 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Regulators of cell death

1995 • 647 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

Positive selection of lymphocytes

1994 • 563 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

1997 • 503 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

Early T Lymphocyte Progenitors

1996 • 473 citations

Control points in early T-cell development

1993 • 429 citations

Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice

1993 • 402 citations

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia.

1994 • 396 citations

The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry.

1996 • 384 citations

Regulation of Lymphocyte Survival by the BCL-2 Gene Family

1995 • 380 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice.

1996 • 301 citations

Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes.

1993 • 286 citations

Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death.

1996 • 284 citations

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control Points

1994 • 252 citations

Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice.

1995 • 245 citations

A gentle fixation and permeabilization method for combined cell surface and intracellular staining with improved precision in DNA quantification

1991 • 235 citations

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine.

1995 • 227 citations

Interleukin-7: a Cofactor For V(D)J Rearrangement of the T Cell Receptor β Gene

1993 • 221 citations

Pro-Thymocyte Expansion by c-kit and the Common Cytokine Receptor γ Chain Is Essential for Repertoire Formation

1997 • 195 citations

IL-7 is a growth and maintenance factor for mature and immature thymocyte subsets

1989 • 180 citations

Effect of IL-7 on the growth of fetal thymocytes in culture.

1989 • 179 citations

Human IL-7: a novel T cell growth factor.

1989 • 172 citations

T-cell lineage commitment and cytokine responses of thymic progenitors

1995 • 164 citations

Characterization of thymic stromal‐derived lymphopoietin (TSLP) in murine B cell development in vitro

1996 • 160 citations

Murine thymocytes proliferate in direct response to interleukin-7

1989 • 157 citations

Role of the Common Cytokine Receptor γ Chain in Cytokine Signaling and Lymphoid Development

1995 • 143 citations

bcl-2 proto-oncogene expression during human T cell development. Evidence for biphasic regulation.

1993 • 140 citations

Induction of TCR Gene Rearrangements in Uncommitted Stem Cells by a Subset of IL-7 Producing, MHC Class II–Expressing Thymic Stromal Cells

1997 • 119 citations

Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival.

1994 • 106 citations

Role of bcl-2 in the Development of Lymphoid Cells From the Hematopoietic Stem Cell

1997 • 83 citations

Analysis of the Role of bcl‐2 in Apoptosis

1994 • 79 citations

Differential effects of Flk-2/Flt-3 ligand and stem cell factor on murine thymic progenitor cells.

1997 • 59 citations

Developmental regulation of bcl-2 expression in the thymus.

1994 • 51 citations

Physiologic roles of interleukin-2, interleukin-4, and interleukin-7

1996 • 14 citations