The expression of Vpre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

A critical role of λ5 protein in B cell development

1992 • 583 citations

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.

1993 • 573 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain.

1990 • 352 citations

Molecular and cellular origins of B lymphocyte diversity

1991 • 346 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma

1986 • 332 citations

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

1993 • 311 citations

A second gene, VpreB in the lambda 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes.

1987 • 306 citations

λ5, a new light-chain-related locus selectively expressed in pre-B lymphocytes

1986 • 302 citations

Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription.

1991 • 289 citations

The surrogate light chain in B-cell development

1993 • 282 citations

The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface.

1990 • 221 citations

Rearrangement and diversity of T cell receptor β chain genes in thymocytes: A critical role for the β chain in development

1993 • 198 citations

Formation of disulphide-linked µ2ω2 tetramers in pre-B cells by the 18K ω-immunoglobulin light chain

1987 • 179 citations

Regulated progression of a cultured pre-B-cell line to the B-cell stage

1985 • 174 citations

Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation

1993 • 170 citations

Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs

1991 • 156 citations

Organization of the murine Ig-related lambda 5 gene transcribed selectively in pre-B lymphocytes.

1987 • 150 citations

A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines.

1993 • 141 citations

Changes in frequencies of clonable pre B cells during life in different lymphoid organs of mice

1993 • 138 citations

Normal pre-B cells express a receptor complex of mu heavy chains and surrogate light-chain proteins.

1991 • 109 citations

Mu heavy chains can associate with a pseudo-light chain complex (ψL) in human pre-B cell lines

1989 • 105 citations

B cell development in mice with a defective λ₅ gene

1993 • 104 citations

The omega/lambda 5 surrogate immunoglobulin light chain is expressed on the surface of transitional B lymphocytes in murine bone marrow.

1991 • 79 citations

Isolation of a cDNA copy of an RNA species expressed in murine pre-B cells.

1986 • 78 citations

The immunoglobulin light chain related protein λ5 is expressed on the surface of mouse pre-B cell lines and can function as a signal transducing molecule

1991 • 77 citations

Two types of mu chain complexes are expressed during differentiation from pre-B to mature B cells.

1990 • 76 citations

The Omega and Iota Surrogate Immunoglobulin Light Chains

1988 • 56 citations

Structure, biosynthesis, and transduction properties of the Human μ-ψL Complex: similar behavior of preB and intermediate preB-B cells in transducing ability

1993 • 44 citations

Cross-linking of B cell receptor-related MB-1 molecule induces protein tyrosine phosphorylation in early B lineage cells.

1993 • 40 citations

B-lineage cells in μ-transgenic scid mice proliferate in response to IL-7 but fail to show evidence of immunoglobulin light chain gene rearrangement

1993 • 36 citations

Association of Ig L chain-like protein lambda 5 with a 16-kilodalton protein in mouse pre-B cell lines is not dependent on the presence of Ig H chain protein.

1990 • 29 citations

Structure, Control of Expression and Putative Function of the PreB Cell-Specific Genes VpreB and λ5

1989 • 28 citations

The expression of the mouse V_preB/λ5 locus in transformed cell lines and tumors of the B lineage differentiation pathway

1992 • 26 citations

Early B cell development requires μ signaling

1993 • 23 citations