Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril

1978 • 4,673 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Death and the cell

1986 • 616 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Enhancement of sheep red blood cell human lymphocyte rosette formation by the sulfhydryl compound 2-amino ethylisothiouronium bromide

1975 • 417 citations

Immunotoxins: A New Approach to Cancer Therapy

1983 • 282 citations

The use of paired labeling in the determination of tumor-localizing antibodies.

1957 • 189 citations

Treatment of B-cell lymphomas with anti-idiotype antibodies alone and in combination with alpha interferon

1989 • 182 citations

Characterization of the cytolytic reaction mechanism of the human natural killer (NK) lymphocyte: resolution into binding, programming, and killer cell-independent steps.

1982 • 177 citations

DNA fragmentation: manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphotoxin-secreting helper T-cell clones, and cell-free lymphotoxin-containing supernatant.

1986 • 152 citations

DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon‐γ

1987 • 127 citations

Isolation of human T and B lymphocytes by E-rosette gradient centrifugation. Characterization of the isolated subpopulations

1980 • 126 citations

Mechanisms of immune lysis. II. CTL-induced nuclear disintegration of the target begins within minutes of cell contact.

1980 • 119 citations

Depletion of monocytes from human peripheral blood mononuclear leukocytes: Comparison of the sephadex G-10 column method with other commonly used techniques

1980 • 117 citations

Cell death in ovarian chambers of Drosophila melanogaster

1976 • 114 citations

DEATH OF CELLS BY APOPTOSIS FOLLOWING ATTACHMENT OF SPECIFICALLY ALLERGIZED LYMPHOCYTES IN VITRO

1977 • 93 citations

Multiple mechanisms of lymphocyte-mediated killing

1988 • 90 citations

THE MECHANISM OF LYMPHOCYTE‐MEDIATED CYTOTOXICITY

1981 • 84 citations

Removal of cells from a malignant B-cell line from bone marrow with immunomagnetic beads and with complement and immunoglobulin switch variant mediated cytolysis

1987 • 37 citations

Internalization of interleukin 1 (IL 1) correlates with IL 1‐induced IL 2 receptor expression and IL 2 secretion of EL4 thymoma cells

1989 • 34 citations

Nuclear disintegration induced by cytotoxic T lymphocytes. Evidence against damage to the nuclear envelope of the target cell.

1988 • 19 citations