Bcl-2 expression promotes B- but not T-lymphoid development in scid mice

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

The SCID Mouse Mutant: Definition, Characterization, and Potential Uses

1991 • 743 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.

1993 • 573 citations

Antigen Receptors on B Lymphocytes

1992 • 509 citations

Germinal center cells express bcl‐2 protein after activation by signals which prevent their entry into apoptosis

1991 • 446 citations

Molecular and cellular origins of B lymphocyte diversity

1991 • 346 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

Isolation of two early B lymphocyte progenitors from mouse marrow: A committed Pre-Pre-B cell and a clonogenic Thy-1lo hematopoietic stem cell

1986 • 330 citations

Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription.

1991 • 289 citations

The surrogate light chain in B-cell development

1993 • 282 citations

Genetic and Mutational Analysis of the T-Cell Antigen Receptor

1990 • 275 citations

The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens

1989 • 219 citations

Monoclonal antibodies to mouse complement receptor type 1 (CR1). Their use in a distribution study showing that mouse erythrocytes and platelets are CR1-negative.

1988 • 162 citations

Positive and negative selection of T cells in T-cellreceptor transgenic mice expressing a bcl-2 transgene.

1994 • 147 citations

Identification and characterization of the murine homologue of CD22, a B lymphocyte-restricted adhesion molecule.

1992 • 99 citations

The expression of B cell surface receptors. I. The ontogeny and distribution of the murine B cell IgE Fc receptor.

1988 • 80 citations

Development of B-lineage cells in the bone marrow of scid/scid mice following the introduction of functionally rearranged immunoglobulin transgenes.

1990 • 68 citations

Dynamics and localization of early B-lymphocyte precursor cells (pro-B cells) in the bone marrow of scid mice

1992 • 44 citations

High frequency of normal DJH joints in B cell progenitors in severe combined immunodeficiency mice.

1993 • 32 citations

Dynamics and localization of early B-lymphocyte precursor cells (pro-B cells) in the bone marrow of scid mice

1992 • 32 citations