FADD/MORT1 and Caspase-8 Are Recruited to TRAIL Receptors 1 and 2 and Are Essential for Apoptosis Mediated by TRAIL Receptor 2

Apoptosis by Death Factor

1997 • 5,038 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Identification and characterization of a new member of the TNF family that induces apoptosis

1995 • 2,890 citations

Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo

1999 • 2,494 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Safety and antitumor activity of recombinant soluble Apo2 ligand

1999 • 2,215 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family

1996 • 1,793 citations

The Receptor for the Cytotoxic Ligand TRAIL

1997 • 1,755 citations

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

1997 • 1,694 citations

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

1997 • 1,506 citations

TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS

1999 • 1,309 citations

Apoptosis control by death and decoy receptors

1999 • 1,296 citations

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

1998 • 1,224 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

Osteoprotegerin Is a Receptor for the Cytotoxic Ligand TRAIL

1998 • 1,177 citations

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL

1997 • 1,119 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

1998 • 893 citations

The Novel Receptor TRAIL-R4 Induces NF-κB and Protects against TRAIL-Mediated Apoptosis, yet Retains an Incomplete Death Domain

1997 • 829 citations

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1998 • 704 citations

Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway

1997 • 685 citations

TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB

1997 • 683 citations

Intracellular Regulation of TRAIL-Induced Apoptosis in Human Melanoma Cells

1998 • 671 citations

A novel receptor for Apo2L/TRAIL contains a truncated death domain

1997 • 650 citations

Cloning and Characterization of TRAIL-R3, a Novel Member of the Emerging TRAIL Receptor Family

1997 • 634 citations

Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II

1999 • 631 citations

Identification and Molecular Cloning of Two Novel Receptors for the Cytotoxic Ligand TRAIL

1997 • 566 citations

Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

1998 • 531 citations

Natural Killer (NK) Cell–mediated Cytotoxicity: Differential Use of TRAIL and Fas Ligand by Immature and Mature Primary Human NK Cells

1998 • 517 citations

Type I Interferons (IFNs) Regulate Tumor Necrosis Factor–related Apoptosis-inducing Ligand (TRAIL) Expression on Human T Cells: A Novel Mechanism for the Antitumor Effects of Type I IFNs

1999 • 477 citations

Monocyte-mediated Tumoricidal Activity via the Tumor Necrosis Factor–related Cytokine, TRAIL

1999 • 470 citations

Human Dendritic Cells Mediate Cellular Apoptosis via Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail)

1999 • 408 citations

FLICE Is Predominantly Expressed as Two Functionally Active Isoforms, Caspase-8/a and Caspase-8/b

1997 • 405 citations

CD95(APO-1/Fas)-Mediated Apoptosis: Live and Let Die

1998 • 405 citations

TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL

1997 • 331 citations

Expression and Function of TNF-Related Apoptosis-Inducing Ligand on Murine Activated NK Cells

1999 • 330 citations

TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling

1998 • 327 citations

TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Apoptosis in Fas Ligand-Resistant Melanoma Cells and Mediates CD4 T Cell Killing of Target Cells

1998 • 316 citations

Activated Human T Cells Release Bioactive Fas Ligand and APO2 Ligand in Microvesicles

1999 • 302 citations

Characterization of two receptors for TRAIL¹

1997 • 293 citations

Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes.

2000 • 292 citations

Tumor necrosis factor-related apoptosis-inducing ligand's antitumor activity in vivo is enhanced by the chemotherapeutic agent CPT-11.

1999 • 263 citations

Functional Analysis of TRAIL Receptors Using Monoclonal Antibodies

1999 • 241 citations

Involvement of TNF-Related Apoptosis-Inducing Ligand in Human CD4+ T Cell-Mediated Cytotoxicity

1999 • 230 citations

Locoregional Apo2L/TRAIL Eradicates Intracranial Human Malignant Glioma Xenografts in Athymic Mice in the Absence of Neurotoxicity

1999 • 214 citations

Differential Localization and Regulation of Death and Decoy Receptors for TNF-Related Apoptosis-Inducing Ligand (TRAIL) in Human Melanoma Cells

2000 • 213 citations

Constitutive Expression and Role of the TNF Family Ligands in Apoptotic Killing of Tumor Cells by Human NK Cells

1999 • 212 citations

Differential regulation of TRAIL and CD95 ligand in transformed cells of the T and B lymphocyte lineage

1998 • 195 citations

Measles Virus Induces Functional TRAIL Production by Human Dendritic Cells

2000 • 186 citations

FADD is required for multiple signaling events downstream of the receptor Fas.

1999 • 179 citations

Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction

1998 • 144 citations

Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL.

1998 • 142 citations

Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry

1997 • 132 citations

Cutting Edge: Lymphocyte Inhibitor of TRAIL (TNF-Related Apoptosis-Inducing Ligand): A New Receptor Protecting Lymphocytes from the Death Ligand TRAIL

1998 • 104 citations

REGULATION OF APO-2 LIGAND/TRAIL EXPRESSION IN NK CELLS—INVOLVEMENT IN NK CELL-MEDIATED CYTOTOXICITY

1999 • 83 citations

The Death Receptors

1999 • 82 citations

The V410I (G1228A) variant of the caspase-10 gene is a common polymorphism in the Danish population

2000 • 40 citations

Murine TRAIL (TNF-Related Apoptosis Inducing Ligand) Expression Induced by T Cell Activation Is Blocked by Rapamycin, Cyclosporin A, and Inhibitors of Phosphatidylinositol 3-Kinase, Protein Kinase C, and Protein Tyrosine Kinases: Evidence for TRAIL Induction via the T Cell Receptor Signaling Pathway

1999 • 21 citations