The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

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Protein folding in the cell

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Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

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XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

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A central role for JNK in obesity and insulin resistance

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

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Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

2000 • 3,071 citations

THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

2005 • 2,964 citations

A genome-wide association study identifies novel risk loci for type 2 diabetes

2007 • 2,957 citations

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2000 • 2,831 citations

Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

2007 • 2,820 citations

A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

2007 • 2,762 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

2000 • 2,696 citations

Broken Limits to Life Expectancy

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Roles of CHOP/GADD153 in endoplasmic reticulum stress

2003 • 2,663 citations

Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes

2006 • 2,303 citations

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

2006 • 2,206 citations

Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

2007 • 2,187 citations

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

2005 • 2,161 citations

Quality control in the endoplasmic reticulum

2003 • 2,061 citations

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

2003 • 1,979 citations

Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

2000 • 1,933 citations

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

1999 • 1,900 citations

Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State

2001 • 1,840 citations

The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

2000 • 1,770 citations

ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

2000 • 1,764 citations

Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress

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IKK-β links inflammation to obesity-induced insulin resistance

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Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

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Islet cell failure in type 2 diabetes

2006 • 1,597 citations

Protein Sensors for Membrane Sterols

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Autophagy: molecular machinery for self-eating

2005 • 1,468 citations

Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes

2005 • 1,413 citations

ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals

2002 • 1,368 citations

BAX and BAK Regulation of Endoplasmic Reticulum Ca ²⁺ : A Control Point for Apoptosis

2003 • 1,363 citations

ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim

2007 • 1,353 citations

A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

2005 • 1,345 citations

Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

2001 • 1,329 citations

Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus.

1996 • 1,306 citations

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

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The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

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Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

2001 • 1,283 citations

Mitochondria

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Decay of Endoplasmic Reticulum-Localized mRNAs During the Unfolded Protein Response

2006 • 1,231 citations

Identification of the cis-Acting Endoplasmic Reticulum Stress Response Element Responsible for Transcriptional Induction of Mammalian Glucose-regulated Proteins

1998 • 1,216 citations

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

2001 • 1,204 citations

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

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ERAD: the long road to destruction

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Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation

2007 • 1,187 citations

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

2002 • 1,031 citations

A Novel Mechanism for Regulating Activity of a Transcription Factor That Controls the Unfolded Protein Response

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Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response

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The endoplasmic reticulum: a multifunctional signaling organelle

2002 • 948 citations

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

2002 • 946 citations

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

2004 • 942 citations

TRB3, a novel ER stress-inducible gene, is induced via ATF4–CHOP pathway and is involved in cell death

2005 • 933 citations

Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

2004 • 928 citations

Endoplasmic Reticulum Stress Triggers Autophagy

2006 • 923 citations

Endoplasmic Reticulum Stress Signaling in Disease

2006 • 914 citations

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

1998 • 888 citations

β-Cell death during progression to diabetes

2001 • 883 citations

Type 2 Diabetes-a Matter of ß-Cell Life and Death?

2005 • 881 citations

A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis

2001 • 880 citations

An Endoplasmic Reticulum Stress-specific Caspase Cascade in Apoptosis

2002 • 875 citations

ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation

2006 • 873 citations

S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

2006 • 862 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 858 citations

Activation of Caspase-12, an Endoplastic Reticulum (ER) Resident Caspase, through Tumor Necrosis Factor Receptor-associated Factor 2-dependent Mechanism in Response to the ER Stress

2001 • 832 citations

A transmembrane protein with a cdc2+CDC28-related kinase activity is required for signaling from the ER to the nucleus

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EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome

2000 • 800 citations

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

2007 • 799 citations

Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response

2006 • 788 citations

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1998 • 782 citations

Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

2001 • 772 citations

CHOP Is Involved in Endoplasmic Reticulum Stress-induced Apoptosis by Enhancing DR5 Expression in Human Carcinoma Cells

2004 • 769 citations

Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins

2006 • 767 citations

Large-Scale Association Studies of Variants in Genes Encoding the Pancreatic β-Cell KATP Channel Subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) Confirm That the KCNJ11 E23K Variant Is Associated With Type 2 Diabetes

2003 • 745 citations

Minireview: Secondary β-Cell Failure in Type 2 Diabetes—A Convergence of Glucotoxicity and Lipotoxicity

2002 • 735 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 724 citations

Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium

2007 • 713 citations

ER chaperones in mammalian development and human diseases

2007 • 709 citations

Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1α-Mediated NF-κB Activation and Down-Regulation of TRAF2 Expression

2006 • 709 citations

Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways

2001 • 696 citations

A Time-Dependent Phase Shift in the Mammalian Unfolded Protein Response

2003 • 670 citations

A membrane protein required for dislocation of misfolded proteins from the ER

2004 • 669 citations

The Importance of β-Cell Failure in the Development and Progression of Type 2 Diabetes

2001 • 668 citations

Two Distinct Stress Signaling Pathways Converge Upon the CHOP Promoter During the Mammalian Unfolded Protein Response

2002 • 666 citations

Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients

2002 • 660 citations

Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea

2003 • 642 citations

Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2

2004 • 621 citations

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

1994 • 605 citations

Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway

2001 • 594 citations

Understanding and Addressing the Epidemic of Obesity: An Energy Balance Perspective

2006 • 592 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2001 • 584 citations

The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas

2002 • 584 citations

β-cells in type II diabetes mellitus

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Islet Pathology and the Pathogenesis of Type 1 and Type 2 Diabetes mellitus Revisited

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Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease

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On the mechanism of sensing unfolded protein in the endoplasmic reticulum

2005 • 561 citations

Free Fatty Acids and Cytokines Induce Pancreatic β-Cell Apoptosis by Different Mechanisms: Role of Nuclear Factor-κB and Endoplasmic Reticulum Stress

2004 • 560 citations

Chronic Palmitate But Not Oleate Exposure Induces Endoplasmic Reticulum Stress, Which May Contribute to INS-1 Pancreatic β-Cell Apoptosis

2006 • 556 citations

A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse

1999 • 555 citations

Caspases in cell survival, proliferation and differentiation

2006 • 553 citations

Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway

2005 • 529 citations

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

2000 • 525 citations

A Subset of Chaperones and Folding Enzymes Form Multiprotein Complexes in Endoplasmic Reticulum to Bind Nascent Proteins

2002 • 514 citations

Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response

2002 • 508 citations

Saturated Fatty Acids Promote Endoplasmic Reticulum Stress and Liver Injury in Rats with Hepatic Steatosis

2005 • 507 citations

Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.

1988 • 506 citations

Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca2+ ATPase 2b and Deplete Endoplasmic Reticulum Ca2+, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells

2005 • 505 citations

The role of assembly in insulin's biosynthesis

1998 • 501 citations

Influence of molecular and chemical chaperones on protein folding

1996 • 496 citations

Endoplasmic Reticulum Stress-induced Apoptosis

2006 • 490 citations

Activating Transcription Factor 3 Is Integral to the Eukaryotic Initiation Factor 2 Kinase Stress Response

2004 • 487 citations

Caspase‐12 and ER‐Stress‐Mediated Apoptosis

2003 • 475 citations

Involvement of Endoplasmic Reticulum Stress in Insulin Resistance and Diabetes

2004 • 467 citations

Stress-induced gene expression requires programmed recovery from translational repression

2003 • 450 citations

XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands

2005 • 437 citations

Delineation of a Negative Feedback Regulatory Loop That Controls Protein Translation during Endoplasmic Reticulum Stress

2003 • 430 citations

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

2004 • 416 citations

GLP-1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress

2006 • 412 citations

Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1

2006 • 412 citations

Ligand-independent Dimerization Activates the Stress Response Kinases IRE1 and PERK in the Lumen of the Endoplasmic Reticulum

2000 • 408 citations

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

2005 • 408 citations

High Expression Rates of Human Islet Amyloid Polypeptide Induce Endoplasmic Reticulum Stress–Mediated β-Cell Apoptosis, a Characteristic of Humans With Type 2 but Not Type 1 Diabetes

2007 • 392 citations

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients

2007 • 390 citations

A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins.

1992 • 375 citations

Common variants in WFS1 confer risk of type 2 diabetes

2007 • 374 citations

Growth Arrest and DNA Damage-Inducible Protein GADD34 Targets Protein Phosphatase 1α to the Endoplasmic Reticulum and Promotes Dephosphorylation of the α Subunit of Eukaryotic Translation Initiation Factor 2

2003 • 374 citations

Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2

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Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action.

2000 • 370 citations

Inhibition of insulin secretion by interleukin‐1β and tumour necrosis factor‐α via an L‐arginine‐dependent nitric oxide generating mechanism

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Gene expression during ER stress–induced apoptosis in neurons

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hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

2004 • 361 citations

Control of PERK eIF2α kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58 ^IPK

2002 • 360 citations

The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response

2006 • 354 citations

Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells.

1992 • 348 citations

Role of Endoplasmic Reticulum Stress and c-Jun NH2-Terminal Kinase Pathways in Inflammation and Origin of Obesity and Diabetes

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Defective co-translational formation of disulphide bonds in protein disulphide-isomerase-deficient microsomes

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Type 1 diabetes: pathogenesis and prevention

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Cytokines suppress human islet function irrespective of their effects on nitric oxide generation.

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Interleukin-lβ-Induced Nitric Oxide Production in Isolated Rat Pancreatic Islets Requires Gene Transcription and May Lead to Inhibition of the Krebs Cycle Enzyme Aconitase*

1991 • 317 citations

Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice

2006 • 317 citations

Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane

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Translational control of proinsulin synthesis by glucose

1980 • 310 citations

Inhibition of a constitutive translation initiation factor 2α phosphatase, CReP, promotes survival of stressed cells

2003 • 309 citations

Role for Activating Transcription Factor 3 in Stress-Induced β-Cell Apoptosis

2004 • 305 citations

A Comprehensive Analysis of Cytokine-induced and Nuclear Factor-κB-dependent Genes in Primary Rat Pancreatic β-Cells

2001 • 302 citations

The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis

2005 • 302 citations

Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells.

1988 • 300 citations

OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes

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Selective Inhibition of Eukaryotic Translation Initiation Factor 2α Dephosphorylation Potentiates Fatty Acid-induced Endoplasmic Reticulum Stress and Causes Pancreatic β-Cell Dysfunction and Apoptosis

2006 • 285 citations

ERO1-L, a Human Protein That Favors Disulfide Bond Formation in the Endoplasmic Reticulum

2000 • 285 citations

The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis

2005 • 280 citations

Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

2006 • 277 citations

Substrate-Specific Translocational Attenuation during ER Stress Defines a Pre-Emptive Quality Control Pathway

2006 • 275 citations

A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum

2007 • 274 citations

Growth Arrest and DNA Damage-Inducible Protein GADD34 Assembles a Novel Signaling Complex Containing Protein Phosphatase 1 and Inhibitor 1

2001 • 271 citations

PERK EIF2AK3 control of pancreatic β cell differentiation and proliferation is required for postnatal glucose homeostasis

2006 • 270 citations

The Natural Course of β-Cell Function in Nondiabetic and Diabetic Individuals

2006 • 268 citations

Endoplasmic Reticulum Oxidoreductin 1-Lβ (ERO1-Lβ), a Human Gene Induced in the Course of the Unfolded Protein Response

2000 • 260 citations

Disruption of the WFS1 gene in mice causes progressive -cell loss and impaired stimulus-secretion coupling in insulin secretion

2004 • 257 citations

ER stress and SREBP-1 activation are implicated in β-cell glucolipotoxicity

2005 • 257 citations

beta-cell apoptosis: stimuli and signaling.

2001 • 255 citations

Role of Disulfide Bridges Formed in the Luminal Domain of ATF6 in Sensing Endoplasmic Reticulum Stress

2006 • 254 citations

Activation Signal of Nuclear Factor-.KAPPA.B in Response to Endoplasmic Reticulum Stress is Transduced via IRE1 and Tumor Necrosis Factor Receptor-Associated Factor 2

2003 • 249 citations

P58IPK, a Novel Endoplasmic Reticulum Stress-inducible Protein and Potential Negative Regulator of eIF2α Signaling

2003 • 246 citations

Endoplasmic Reticulum Stress Stimulates the Expression of Cyclooxygenase-2 through Activation of NF-κB and pp38 Mitogen-activated Protein Kinase

2004 • 243 citations

Conditional and specific NF-κB blockade protects pancreatic beta cells from diabetogenic agents

2006 • 240 citations

WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic β-cells

2006 • 237 citations

Identification of Novel Cytokine-Induced Genes in Pancreatic β-Cells by High-Density Oligonucleotide Arrays

2001 • 231 citations

The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress—elucidation by GADD34‐deficient mice

2003 • 230 citations

Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

2001 • 228 citations

Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells

2003 • 224 citations

Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis

2005 • 222 citations

Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells

1998 • 219 citations

The Endoplasmic Reticulum Chaperone Improves Insulin Resistance in Type 2 Diabetes

2005 • 213 citations

Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).

2000 • 211 citations

Pancreatic β-Cell Failure and Diabetes in Mice With a Deletion Mutation of the Endoplasmic Reticulum Molecular Chaperone Gene P58IPK

2005 • 207 citations

Endoplasmic reticulum stress signaling transmitted by ATF6 mediates apoptosis during muscle development

2005 • 207 citations

Apoptosis Is the Mode of β-Cell Death Responsible for the Development of IDDM in the Nonobese Diabetic (NOD) Mouse

1997 • 203 citations

The Role of p58^IPK in Protecting the Stressed Endoplasmic Reticulum

2007 • 203 citations

Versatility of the Endoplasmic Reticulum Protein Folding Factory

2005 • 202 citations

Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic β-cell dysfunction and insulin resistance

2006 • 200 citations

Translational control of insulin biosynthesis. Evidence for regulation of elongation, initiation and signal-recognition-particle-mediated translational arrest by glucose

1986 • 187 citations

Translocation of Bim to the Endoplasmic Reticulum (ER) Mediates ER Stress Signaling for Activation of Caspase-12 during ER Stress-induced Apoptosis

2004 • 187 citations

Wolcott-Rallison Syndrome

2004 • 181 citations

The Unfolded Protein Response Pathway in

1996 • 180 citations

Underglycosylation of ATF6 as a Novel Sensing Mechanism for Activation of the Unfolded Protein Response

2004 • 175 citations

beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes.

2001 • 175 citations

BH3-only BIK Regulates BAX,BAK-dependent Release of Ca2+ from Endoplasmic Reticulum Stores and Mitochondrial Apoptosis during Stress-induced Cell Death

2005 • 175 citations

Progressive Loss of β-Cell Function Leads to Worsening Glucose Tolerance in First-Degree Relatives of Subjects With Type 2 Diabetes

2007 • 164 citations

Bax and the mitochondrial permeability transition cooperate in the release of cytochrome c during endoplasmic reticulum-stress-induced apoptosis

2006 • 156 citations

Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

2001 • 155 citations

Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe β-Cell Loss in Munich Ins2C95S Mutant Mice

2007 • 150 citations

Protein Folding in the Endoplasmic Reticulum and the Unfolded Protein Response

2005 • 150 citations

Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets

2007 • 148 citations

Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane

1999 • 147 citations

Banting lecture 1990. Beta-cells in type II diabetes mellitus

1991 • 147 citations

Gene‐specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2

1993 • 146 citations

Palindrome with Spacer of One Nucleotide Is Characteristic of the cis-Acting Unfolded Protein Response Element inSaccharomyces cerevisiae

1998 • 146 citations

The protective and destructive roles played by molecular chaperones during ERAD (endoplasmic-reticulum-associated degradation)

2007 • 146 citations

Real-Time Fluorescence Detection of ERAD Substrate Retrotranslocation in a Mammalian In Vitro System

2007 • 137 citations

Impairment of the Ubiquitin-Proteasome Pathway Is a Downstream Endoplasmic Reticulum Stress Response Induced by Extracellular Human Islet Amyloid Polypeptide and Contributes to Pancreatic β-Cell Apoptosis

2007 • 136 citations

Cytokine-Induced Proapoptotic Gene Expression in Insulin-Producing Cells Is Related to Rapid, Sustained, and Nonoscillatory Nuclear Factor-κB Activation

2006 • 134 citations

Luman, the Cellular Counterpart of Herpes Simplex Virus VP16, Is Processed by Regulated Intramembrane Proteolysis

2002 • 134 citations

Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism.

1998 • 133 citations

Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs

2007 • 130 citations

The adipocyte–myocyte axis in insulin resistance

2006 • 126 citations

Is There a Role for Locally Produced Interleukin-1 in the Deleterious Effects of High Glucose or the Type 2 Diabetes Milieu to Human Pancreatic Islets?

2005 • 126 citations

Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumour necrosis factor-α in patients with recent-onset type 1 diabetes

2007 • 125 citations

Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreaticβ-cell

2000 • 122 citations

Endoplasmic Reticulum Stress Induces Apoptosis by an Apoptosome-dependent but Caspase 12-independent Mechanism

2005 • 122 citations

Divergent Roles of IRE1α and PERK in the Unfolded Protein Response

2006 • 120 citations

Mitogen-Activated Protein Kinases, Inhibitory-κB Kinase, and Insulin Signaling in Human Omental Versus Subcutaneous Adipose Tissue in Obesity

2007 • 114 citations

Self-association and BiP dissociation are not sufficient for activation of the ER stress sensor Ire1

2007 • 112 citations

Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine-induced murine beta-cell damage.

2000 • 110 citations

Genetic Regulation of Birth Weight and Fasting Glucose by a Common Polymorphism in the Islet Cell Promoter of the Glucokinase Gene

2005 • 110 citations

Interleukin‐1β induces the expression of an isoform of nitric oxide synthase in insulin‐producing cells, which is similar to that observed in activated macrophages

1992 • 110 citations

Immune Cell Infiltration, Cytokine Expression, and β-Cell Apoptosis During the Development of Type 1 Diabetes in the Spontaneously Diabetic LEW.1AR1/Ztm-iddmRat

2005 • 109 citations

Transcriptional Regulation of the Endoplasmic Reticulum Stress Gene Chop in Pancreatic Insulin-Producing Cells

2007 • 107 citations

Involvement of caspase-2 and caspase-9 in endoplasmic reticulum stress-induced apoptosis: A role for the IAPs

2006 • 103 citations

The Control of Endoplasmic Reticulum-Initiated Apoptosis by the BCL-2 Family of Proteins

2006 • 102 citations

Protection of pancreatic β-cells by exendin-4 may involve the reduction of endoplasmic reticulum stress; in vivo and in vitro studies

2007 • 102 citations

CHOP plays a pivotal role in the astrocyte death induced by oxygen and glucose deprivation

2005 • 102 citations

Disruption of the γ-Interferon Signaling Pathway at the Level of Signal Transducer and Activator of Transcription-1 Prevents Immune Destruction of β-cells

2005 • 101 citations

Endoplasmic Reticulum Stress-induced Death of Mouse Embryonic Fibroblasts Requires the Intrinsic Pathway of Apoptosis

2007 • 97 citations

Unconventional Splicing of HAC1/ERN4 mRNA Required for the Unfolded Protein Response

1998 • 92 citations

Association Studies of Genetic Variation in the WFS1 Gene and Type 2 Diabetes in U.K. Populations

2002 • 89 citations

Common variants in HNF-1 α and risk of type 2 diabetes

2006 • 88 citations

Interferon-γ potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms

2006 • 85 citations

Glucose Activates a Protein Phosphatase-1-Mediated Signaling Pathway to Enhance Overall Translation in Pancreatic β-Cells

2006 • 80 citations

Association of Amino Acid Variants in the Activating Transcription Factor 6 Gene (ATF6) on 1q21-q23 With Type 2 Diabetes in Pima Indians

2006 • 78 citations

Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic β-cell dysfunction and insulin resistance

2005 • 78 citations

Reversal of beta-cell suppression in vitro in pancreatic islets isolated from nonobese diabetic mice during the phase preceding insulin-dependent diabetes mellitus.

1990 • 76 citations

Sec61p Serves Multiple Roles in Secretory Precursor Binding and Translocation into the Endoplasmic Reticulum Membrane

1998 • 75 citations

Endoplasmic Reticulum Stress and Neurodegeneration in Rats Neonatally Infected with Borna Disease Virus

2006 • 72 citations

Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nuclease.

2004 • 72 citations

Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway

2005 • 67 citations

Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation

2007 • 67 citations

Global profiling of double stranded RNA- and IFN-?-induced genes in rat pancreatic beta cells

2003 • 66 citations

Accumulation of Misfolded Protein Through Nitrosative Stress Linked to Neurodegenerative Disorders

2007 • 64 citations

Autopsy Findings in the Wolcott-Rallison Syndrome

1997 • 63 citations

Caspases‐2, ‐3, and ‐7 are involved in thapsigargin‐induced apoptosis of SH‐SY5Y neuroblastoma cells

2005 • 62 citations

Functional Characteristics of Rat Pancreatic Islets Maintained in Culture After Exposure to Human Interleukin 1

1988 • 60 citations

Endoplasmic Reticulum Stress Increases Glucose-6-Phosphatase and Glucose Cycling in Liver Cells

2005 • 58 citations

Proteomic screening of glucose-responsive and glucose non-responsive MIN-6 beta cells reveals differential expression of proteins involved in protein folding, secretion and oxidative stress

2006 • 57 citations

Stress, the Endoplasmic Reticulum, and Insulin Resistance

2006 • 56 citations

Bcl-2 acts subsequent to and independent of Ca2+ fluxes to inhibit apoptosis in thapsigargin- and glucocorticoidmtreated mouse lymphoma cells

1996 • 56 citations

Probe-Independent and Direct Quantification of Insulin mRNA and Growth Hormone mRNA in Enriched Cell Preparations

2006 • 55 citations

Deletion of STAT-1 Pancreatic Islets Protects Against Streptozotocin-Induced Diabetes and Early Graft Failure but Not Against Late Rejection

2007 • 54 citations

The Transcriptional Co-activator ADA5 Is Required for HAC1 mRNA Processing in Vivo

2000 • 52 citations

Genotoxic Agents Increase Expression of Growth Arrest and DNA Damage–Inducible Genes gadd 153 and gadd 45 in Rat Pancreatic Islets

1993 • 48 citations

CHOP is involved in neuronal apoptosis induced by neurotrophic factor deprivation

2006 • 42 citations

The amyloid precursor protein potentiates CHOP induction and cell death in response to ER Ca2+ depletion

2006 • 42 citations

Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic β-cells

2007 • 40 citations

Retention of mRNA on the endoplasmic reticulum membranes after in vivo disassembly of polysomes by an inhibitor of initiation.

1976 • 39 citations

Glucose regulated proteins 78 protects insulinoma cells (NIT-1) from death induced by streptozotocin, cytokines or cytotoxic T lymphocytes

2007 • 34 citations

Interaction between endoplasmic reticulum stress and caspase 8 activation in retrovirus MoMuLV-ts1-infected astrocytes

2006 • 33 citations

Activation of the ER stress gene gadd153 by hepatitis C virus sensitizes cells to oxidant injury

2007 • 32 citations

Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic β-cells

2007 • 32 citations

Calmodulin Overexpression Causes Ca2+-Dependent Apoptosis of Pancreatic β Cells, Which Can Be Prevented by Inhibition of Nitric Oxide Synthase

2002 • 28 citations

bcl-2 protects HL-60 cells from apoptosis by stabilizing their intracellular calcium pools

2001 • 27 citations

Blood Glucose-Lowering Nuclear Receptor Agonists Only Partially Normalize Hepatic Gene Expression in db/db Mice

2005 • 27 citations

Beta cell death in hyperglycaemic Psammomys obesus is not cytokine-mediated

2006 • 26 citations

Polymorphisms in the Glucokinase-Associated, Dual-Specificity Phosphatase 12 (DUSP12) Gene Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes

2006 • 26 citations

Effect of Various Concentrations of Glucose on Insulin Biosynthesis

1972 • 25 citations

Abundant Expression of 150-kDa Oxygen-Regulated Protein in Mouse Pancreatic Beta Cells Is Correlated with Insulin Secretion

2000 • 22 citations

Prolonged exposure of pancreatic islets isolated from ?pre-diabetic? non-obese diabetic mice to a high glucose concentration does not impair Beta-cell function

1991 • 20 citations

Insulin secretion in obese and non-obese NIDDM

1995 • 12 citations