The adipocyte–myocyte axis in insulin resistance

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

2003 • 8,996 citations

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 8,349 citations

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 7,795 citations

Adipose Tissue as an Endocrine Organ

2004 • 5,220 citations

THE GLUCOSE FATTY-ACID CYCLE ITS ROLE IN INSULIN SENSITIVITY AND THE METABOLIC DISTURBANCES OF DIABETES MELLITUS

1963 • 5,061 citations

Increased oxidative stress in obesity and its impact on metabolic syndrome

2004 • 4,840 citations

C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus

2001 • 4,289 citations

Inflammation, stress, and diabetes

2005 • 3,786 citations

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

2004 • 3,671 citations

Obesity

2005 • 3,509 citations

Obesity and insulin resistance

2000 • 3,076 citations

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

2006 • 2,496 citations

Reactive oxygen species have a causal role in multiple forms of insulin resistance

2006 • 2,397 citations

Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

2002 • 2,244 citations

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

2004 • 2,151 citations

Adipokines: inflammation and the pleiotropic role of white adipose tissue

2004 • 2,127 citations

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

2005 • 2,028 citations

Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

2001 • 1,843 citations

Human Epicardial Adipose Tissue Is a Source of Inflammatory Mediators

2003 • 1,789 citations

IKK-β links inflammation to obesity-induced insulin resistance

2005 • 1,710 citations

Comparison of the Release of Adipokines by Adipose Tissue, Adipose Tissue Matrix, and Adipocytes from Visceral and Subcutaneous Abdominal Adipose Tissues of Obese Humans

2004 • 1,518 citations

Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects

2006 • 1,284 citations

Metabolic Syndrome

2005 • 1,273 citations

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction

2002 • 1,264 citations

Inflammation, stress, and diabetes

2005 • 1,203 citations

Monocyte chemoattractant protein 1 in obesity and insulin resistance

2003 • 1,163 citations

Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss

2005 • 1,127 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Interleukin-6 (IL-6) Induces Insulin Resistance in 3T3-L1 Adipocytes and Is, Like IL-8 and Tumor Necrosis Factor-α, Overexpressed in Human Fat Cells from Insulin-resistant Subjects

2003 • 1,014 citations

Interleukin-6 Induces Cellular Insulin Resistance in Hepatocytes

2002 • 842 citations

Adiponectin – journey from an adipocyte secretory protein to biomarker of the metabolic syndrome

2005 • 758 citations

Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex

2002 • 742 citations

THE GLUCOSE-FATTY ACID CYCLE

1981 • 734 citations

Modulation of Insulin Activities by Leptin

1996 • 733 citations

Interleukin-6 Stimulates Lipolysis and Fat Oxidation in Humans

2003 • 710 citations

Potential Role of TNF-α in the Pathogenesis of Insulin Resistance and Type 2 Diabetes

2000 • 692 citations

Adiponectin: action, regulation and association to insulin sensitivity

2005 • 631 citations

Is visceral obesity the cause of the metabolic syndrome?

2006 • 623 citations

Plasma Adiponectin Concentrations Predict Insulin Sensitivity of Both Glucose and Lipid Metabolism

2003 • 591 citations

Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-α

2003 • 517 citations

Endocrine and signalling role of adipose tissue: new perspectives on fat

2005 • 492 citations

Leptin Impairs Metabolic Actions of Insulin in Isolated Rat Adipocytes

1997 • 463 citations

Importance of Weight Management in Type 2 Diabetes: Review with Meta-analysis of Clinical Studies

2003 • 453 citations

Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance

2003 • 447 citations

Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression

2006 • 426 citations

Epidemiology, Trends, and Morbidities of Obesity and the Metabolic Syndrome

2006 • 421 citations

Endoplasmic reticulum stress in health and disease

2006 • 420 citations

Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes

2004 • 408 citations

IL-6 and TNF-α expression in, and release from, contracting human skeletal muscle

2002 • 389 citations

Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling

2005 • 389 citations

Functions of AMP‐activated protein kinase in adipose tissue

2006 • 388 citations

Insulin action and insulin resistance in human skeletal muscle

2000 • 365 citations

Peroxisome Proliferator—Activated Receptor (PPAR)-αActivation Lowers Muscle Lipids and Improves Insulin Sensitivity in High Fat—Fed Rats

2001 • 348 citations

Inhibition of Insulin Sensitivity by Free Fatty Acids Requires Activation of Multiple Serine Kinases in 3T3-L1 Adipocytes

2004 • 336 citations

M<scp>USCLE</scp> T<scp>RIGLYCERIDE AND</scp> I<scp>NSULIN</scp> R<scp>ESISTANCE</scp>

2002 • 333 citations

Adiposity Elevates Plasma MCP-1 Levels Leading to the Increased CD11b-positive Monocytes in Mice

2003 • 324 citations

Leptin: Structure, Function and Biology

2005 • 323 citations

Intramuscular Heat Shock Protein 72 and Heme Oxygenase-1 mRNA Are Reduced in Patients With Type 2 Diabetes

2003 • 317 citations

Macrophage-secreted factors induce adipocyte inflammation and insulin resistance

2006 • 296 citations

Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice

2002 • 273 citations

Inflammation and the etiology of type 2 diabetes

2005 • 234 citations

Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes

2006 • 231 citations

Long-Term Efficacy of Leptin Replacement in Patients With Generalized Lipodystrophy

2005 • 224 citations

Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice

2002 • 224 citations

Monocyte Chemotactic Protein-1 Is a Potential Player in the Negative Cross-Talk between Adipose Tissue and Skeletal Muscle

2006 • 216 citations

Pathways from obesity to diabetes

2002 • 209 citations

Increased p85/55/50 Expression and Decreased Phosphotidylinositol 3-Kinase Activity in Insulin-Resistant Human Skeletal Muscle

2005 • 201 citations

Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat.

1999 • 200 citations

Suppressor of Cytokine Signaling 3 Expression and Insulin Resistance in Skeletal Muscle of Obese and Type 2 Diabetic Patients

2004 • 192 citations

Cross-talk between skeletal muscle and adipose tissue: A link with obesity?

2004 • 188 citations

Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: Evidence for a skeletal muscle-to-fat signaling pathway

2005 • 186 citations

Impairment of Insulin Signaling in Human Skeletal Muscle Cells by Co-Culture With Human Adipocytes

2002 • 181 citations

Downregulation of Electron Transport Chain Genes in Visceral Adipose Tissue in Type 2 Diabetes Independent of Obesity and Possibly Involving Tumor Necrosis Factor-α

2006 • 180 citations

Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control

2001 • 174 citations

Defective Signaling Through Akt-2 and -3 But Not Akt-1 in Insulin-Resistant Human Skeletal Muscle

2003 • 168 citations

Correction of obesity and diabetes in genetically obese mice by leptin gene therapy

1996 • 160 citations

Autocrine Action of Adiponectin on Human Fat Cells Prevents the Release of Insulin Resistance-Inducing Factors

2005 • 149 citations

Fatty acids and insulin resistance in muscle and liver

2005 • 148 citations

The delicate balance between fat and muscle: adipokines in metabolic disease and musculoskeletal inflammation

2004 • 141 citations

Inflamed about obesity

2004 • 138 citations

Skeletal muscle triglyceride: Marker or mediator of obesity-induced insulin resistance in type 2 diabetes mellitus?

2002 • 134 citations

Molecular mechanisms of lipid‐induced insulin resistance in muscle, liver and vasculature

2004 • 123 citations

Sulfasalazine and BAY 11-7082 Interfere with the Nuclear Factor-κB and IκB Kinase Pathway to Regulate the Release of Proinflammatory Cytokines from Human Adipose Tissue and Skeletal Muscle in Vitro

2004 • 102 citations

Obesity and metabolic disease: is adipose tissue the culprit?

2005 • 100 citations

High Leptin Levels Acutely Inhibit Insulin-Stimulated Glucose Uptake without Affecting Glucose Transporter 4 Translocation in L6 Rat Skeletal Muscle Cells

2001 • 99 citations

Macrophage-conditioned medium inhibits the differentiation of 3T3-L1 and human abdominal preadipocytes

2006 • 98 citations

Effects of Tumor Necrosis Factor-α on Insulin Action in Cultured Human Muscle Cells

2001 • 97 citations

Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser⁴⁷³ of Akt

2005 • 91 citations

Fat storage in pancreas and in insulin-sensitive tissues in pathogenesis of type 2 diabetes

2004 • 69 citations

Adipose tissue changes in obesity

2005 • 66 citations

Central regulation of energy balance: inputs, outputs and leptin resistance

2005 • 65 citations

Lipopolysaccharide stimulates nitric oxide synthase-2 expression in murine skeletal muscle and C₂C₁₂myoblasts via Toll-like receptor-4 and c-Jun NH₂-terminal kinase pathways

2004 • 57 citations

Effects of interleukin-15 on lipid oxidation

2006 • 53 citations

Inhibitor κB kinase is involved in the paracrine crosstalk between human fat and muscle cells

2004 • 46 citations

PKCθ is a key player in the development of insulin resistance

2006 • 42 citations

From lipodystrophy syndromes to diabetes mellitus

2001 • 41 citations

High Leptin Levels Acutely Inhibit Insulin-Stimulated Glucose Uptake without Affecting Glucose Transporter 4 Translocation in L6 Rat Skeletal Muscle Cells

2001 • 32 citations

Obesity, inflammation and type II diabetes

2003 • 25 citations

Proinflammatory adipocytokines induce TIMP‐1 expression in 3T3‐L1 adipocytes

2005 • 25 citations

Adipose tissue changes in obesity

2005 • 22 citations

Potential Role of TNF-a in the Pathogenesis of Insulin Resistance and Type 2 Diabetes

2000 • 21 citations

New progress in adipocytokine research

2003 • 21 citations

Analysis of insulin-stimulated insulin receptor activation and glucose transport in cultured skeletal muscle cells from obese subjects

2005 • 18 citations

Acute Hyperleptinemia Does Not Modify Insulin Sensitivityin vivoin the Rat

1998 • 15 citations

Tissue inhibitor of metalloproteinase 1 expression and secretion are induced by β-adrenergic stimulation in 3T3-L1 adipocytes

2006 • 9 citations