Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

2000 • 3,071 citations

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 • 2,831 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

2000 • 1,939 citations

Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

2001 • 1,329 citations

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

2001 • 1,204 citations

Tripartite Management of Unfolded Proteins in the Endoplasmic Reticulum

2000 • 917 citations

EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome

2000 • 800 citations

Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway

2001 • 594 citations

A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse

1999 • 555 citations

ER Quality Control: The Cytoplasmic Connection

1997 • 528 citations

Cellular composition of the human diabetic pancreas

1983 • 394 citations

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

1994 • 331 citations

Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells

1996 • 317 citations

Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153).

1995 • 230 citations

Role of C/EBP homologous protein (CHOP-10) in the programmed activation of CCAAT/enhancer-binding protein-β during adipogenesis

2000 • 164 citations

Compensatory responses in mice carrying a null mutation for Ins1 or Ins2.

2001 • 134 citations

Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period.

1998 • 96 citations

A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice

1997 • 79 citations

Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans

1982 • 75 citations

Coinduction of Endothelial Nitric Oxide Synthase and Arginine Recycling Enzymes in Aorta of Diabetic Rats

2001 • 62 citations

AUTOPSY FINDINGS IN THE WOLCOTT-RALLISON SYNDROME

1997 • 23 citations

Function, mass, and replication of porcine and rat islets transplanted into diabetic nude mice

1995 • 17 citations