Involvement of caspase-2 and caspase-9 in endoplasmic reticulum stress-induced apoptosis: A role for the IAPs

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

IAP proteins: blocking the road to death's door

2002 • 1,753 citations

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1998 • 1,394 citations

BAX and BAK Regulation of Endoplasmic Reticulum Ca ²⁺ : A Control Point for Apoptosis

2003 • 1,363 citations

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

1997 • 1,316 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

Cross-Talk between Two Cysteine Protease Families

2000 • 1,158 citations

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death

2004 • 813 citations

Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

2001 • 772 citations

Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization

2002 • 727 citations

The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress

2004 • 654 citations

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

2001 • 644 citations

A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases

1998 • 611 citations

IAPs, RINGs and ubiquitylation

2005 • 591 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2001 • 584 citations

Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

2002 • 560 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2002 • 480 citations

The inhibitors of apoptosis: there is more to life than Bcl2

2003 • 440 citations

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

1999 • 388 citations

Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes

2001 • 388 citations

Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis

2000 • 379 citations

The Human Anti-apoptotic Proteins cIAP1 and cIAP2 Bind but Do Not Inhibit Caspases

2005 • 365 citations

Human caspase 12 has acquired deleterious mutations

2002 • 348 citations

Caspase-2 Mediates Neuronal Cell Death Induced by β-Amyloid

2000 • 346 citations

The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7.

2000 • 336 citations

Critical Role of Endogenous Akt/IAPs and MEK1/ERK Pathways in Counteracting Endoplasmic Reticulum Stress-induced Cell Death

2004 • 319 citations

The Inhibitor of Apoptosis, cIAP2, Functions as a Ubiquitin-Protein Ligase and Promotes in VitroMonoubiquitination of Caspases 3 and 7

2000 • 294 citations

The death effector domain protein family: regulators of cellular homeostasis

2003 • 222 citations

Inhibitor of Apoptosis Protein cIAP2 Is Essential for Lipopolysaccharide-Induced Macrophage Survival

2005 • 188 citations

Posttranscriptional Downregulation of c-IAP2 by the Ubiquitin Protein Ligase c-IAP1 In Vivo

2005 • 185 citations

Human Ovarian Cancer and Cisplatin Resistance: Possible Role of Inhibitor of Apoptosis Proteins¹

2001 • 183 citations

Inhibitor of Apoptosis Proteins Are Substrates for the Mitochondrial Serine Protease Omi/HtrA2

2003 • 182 citations

Activation of Caspase-2 in Apoptosis

1997 • 181 citations

Caspase-12 and Caspase-4 Are Not Required for Caspase-dependent Endoplasmic Reticulum Stress-induced Apoptosis

2005 • 172 citations

Sequential Caspase-2 and Caspase-8 Activation Upstream of Mitochondria during Ceramideand Etoposide-induced Apoptosis

2004 • 130 citations

Caspase-12: an overview

2003 • 130 citations

Adenovirus‐Mediated Gene Transfer of Inhibitors of Apoptosis Proteins Delays Apoptosis in Cerebellar Granule Neurons

1999 • 129 citations

Caspase-2 redux

2003 • 128 citations

XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis

2002 • 124 citations

BiP is feed-back regulated by control of protein translation efficiency

2002 • 118 citations

Caspase-2 Permeabilizes the Outer Mitochondrial Membrane and Disrupts the Binding of Cytochrome c to Anionic Phospholipids

2004 • 115 citations

Proapoptotic BAX and BAK control multiple initiator caspases

2005 • 112 citations

Crystal Structure of Caspase-2, Apical Initiator of the Intrinsic Apoptotic Pathway

2003 • 106 citations

Neutralization of Smac/Diablo by Inhibitors of Apoptosis (IAPs)

2004 • 105 citations

Caspase-2-induced Apoptosis Is Dependent on Caspase-9, but Its Processing during UV- or Tumor Necrosis Factor-dependent Cell Death Requires Caspase-3

2001 • 103 citations

The Polypeptide Chain-releasing Factor GSPT1/eRF3 Is Proteolytically Processed into an IAP-binding Protein

2003 • 92 citations

Death from within: apoptosis and the secretory pathway

2003 • 74 citations

Caspases‐2, ‐3, and ‐7 are involved in thapsigargin‐induced apoptosis of SH‐SY5Y neuroblastoma cells

2005 • 62 citations

A Novel Ubiquitin Fusion System Bypasses the Mitochondria and Generates Biologically Active Smac/DIABLO

2003 • 57 citations

Caspase‐3 and inhibitor of apoptosis protein(s) interactions in Saccharomyces cerevisiae and mammalian cells

2000 • 41 citations

Caspase‐2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase‐7

2005 • 31 citations