A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

2003 • 3,079 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

Characterization of Mammalian Selenoproteomes

2003 • 2,241 citations

Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

2000 • 1,939 citations

Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans

2001 • 1,779 citations

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1996 • 1,101 citations

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

2001 • 1,088 citations

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

1996 • 1,083 citations

A membrane protein required for dislocation of misfolded proteins from the ER

2004 • 669 citations

Retro-translocation of proteins from the endoplasmic reticulum into the cytosol

2002 • 637 citations

Function of the p97–Ufd1–Npl4 complex in retrotranslocation from the ER to the cytosol

2003 • 585 citations

AAA-ATPase p97/Cdc48p, a Cytosolic Chaperone Required for Endoplasmic Reticulum-Associated Protein Degradation

2002 • 542 citations

Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48

2002 • 530 citations

Protein Disulfide Isomerase Acts as a Redox-Dependent Chaperone to Unfold Cholera Toxin

2001 • 483 citations

The ERO1 Gene of Yeast Is Required for Oxidation of Protein Dithiols in the Endoplasmic Reticulum

1998 • 482 citations

Role of EDEM in the Release of Misfolded Glycoproteins from the Calnexin Cycle

2003 • 464 citations

Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

2004 • 454 citations

EDEM As an Acceptor of Terminally Misfolded Glycoproteins Released from Calnexin

2003 • 446 citations

A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways

2000 • 438 citations

Ero1p: A Novel and Ubiquitous Protein with an Essential Role in Oxidative Protein Folding in the Endoplasmic Reticulum

1998 • 438 citations

Manipulating disulfide bond formation and protein folding in the endoplasmic reticulum.

1992 • 405 citations

ER quality control: towards an understanding at the molecular level

2001 • 392 citations

Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast.

1996 • 385 citations

Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains

2003 • 374 citations

Molecular Chaperones in the Yeast Endoplasmic Reticulum Maintain the Solubility of Proteins for Retrotranslocation and Degradation

2001 • 328 citations

HRD4/NPL4Is Required for the Proteasomal Processing of Ubiquitinated ER Proteins

2001 • 304 citations

Endoplasmic Reticulum Degradation Requires Lumen to Cytosol Signaling

2000 • 302 citations

Integration of endoplasmic reticulum signaling in health and disease

1999 • 280 citations

AAA proteases: cellular machines for degrading membrane proteins

2000 • 224 citations

A survival pathway forCaenorhabditis eleganswith a blocked unfolded protein response

2002 • 200 citations

Export of a Cysteine-Free Misfolded Secretory Protein from the Endoplasmic Reticulum for Degradation Requires Interaction with Protein Disulfide Isomerase

1999 • 194 citations

Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation

1999 • 181 citations

Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress – SelS is a novel glucose‐regulated protein

2004 • 161 citations

The Pathway of Us11-Dependent Degradation of Mhc Class I Heavy Chains Involves a Ubiquitin-Conjugated Intermediate

1999 • 150 citations

Der1p, a protein required for degradation of malfolded soluble proteins of the endoplasmic reticulum: topology and Der1-like proteins

2004 • 99 citations

Polyubiquitin Serves as a Recognition Signal, Rather than a Ratcheting Molecule, during Retrotranslocation of Proteins across the Endoplasmic Reticulum Membrane

2003 • 92 citations

The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products

1999 • 85 citations

Substrate recognition in ER-associated degradation mediated by Eps1, a member of the protein disulfide isomerase family

2003 • 58 citations

Reconstitution of Membrane Proteolysis by FtsH

2003 • 41 citations

Dislocation of a Type I Membrane Protein Requires Interactions between Membrane-spanning Segments within the Lipid Bilayer

2003 • 38 citations