The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 • 3,119 citations

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

2000 • 2,696 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

2000 • 1,933 citations

Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

2001 • 1,329 citations

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

2001 • 1,204 citations

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

1996 • 1,124 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

Protein translocation across the endoplasmic reticulum

1984 • 825 citations

EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome

2000 • 800 citations

Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control

1998 • 763 citations

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.

1995 • 640 citations

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1994 • 569 citations

Translational Regulation of Yeast GCN4

1997 • 533 citations

Mechanism of Protein Translocation Across the Endoplasmic Reticulum Membrane

1986 • 509 citations

The Pancreas : biology, pathobiology, and disease

1993 • 501 citations

Translational control

1991 • 464 citations

Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle.

1982 • 388 citations

Phosphorylation of Eukaryotic Translation Initiation Factor 2 Mediates Apoptosis in Response to Activation of the Double-stranded RNA-dependent Protein Kinase

1998 • 380 citations

Osteoblasts isolated from mouse calvaria initiate matrix mineralization in culture.

1983 • 363 citations

The Pancreas: Biology, Pathobiology, and Disease

1994 • 305 citations

Regulation of protein synthesis by heme-regulated eIF-2α kinase

1995 • 297 citations

A Mammalian Homologue of GCN2 Protein Kinase Important for Translational Control by Phosphorylation of Eukaryotic Initiation Factor-2α

2000 • 276 citations

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2α kinase

1999 • 254 citations

Characterization of Transgenic Mice with Targeted Disruption of the Catalytic Domain of the Double-stranded RNA-dependent Protein Kinase, PKR

1999 • 228 citations

Translational control of insulin biosynthesis. Evidence for regulation of elongation, initiation and signal-recognition-particle-mediated translational arrest by glucose

1986 • 187 citations

Translation Inhibition in Apoptosis

2001 • 175 citations

Pancreatic eukaryotic initiation factor-2α kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

2000 • 147 citations

7 Translational Control of GCN4: Gene-specific Regulation by Phosphorylation of elF2

1996 • 143 citations

elF-2 kinases: regulators of general and gene-specific translation initiation

1994 • 140 citations

The eIF-2α kinases: regulators of protein synthesis in starvation and stress

1994 • 130 citations

Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreaticβ-cell

2000 • 122 citations

Collagen type I synthesized by pancreatic periacinar stellate cells (PSC) co-localizes with lipid peroxidation-derived aldehydes in chronic alcoholic pancreatitis

2000 • 121 citations

Pancreatic eukaryotic initiation factor-2α kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

2000 • 109 citations

Heterozygosity for a large deletion in the alpha 2(I) collagen gene has a dramatic effect on type I collagen secretion and produces perinatal lethal osteogenesis imperfecta.

1988 • 83 citations

β-granule transport and exocytosis

2000 • 81 citations

Wolcott-Rallison syndrome: Diabetes mellitus and spondyloepiphyseal dysplasia

1982 • 72 citations

The effect of glucose on insulin biosynthesis by isolated islets of langerhans of the rat

1970 • 68 citations

Glucose Regulation of Free Ca2+ in the Endoplasmic Reticulum of Mouse Pancreatic Beta Cells

1999 • 63 citations

Effect of Glucose on Initiation and Elongation Rates in Isolated Rat Pancreatic Islets

1974 • 58 citations

Glucose stimulation of the proinsulin synthesis in isolated pancreatic islets without increasing amount of proinsulin mRNA

1978 • 48 citations

Protein kinases that phosphorylate eIF-2 and eIF-2B, and their role in eukaryotic cell translational control.

1996 • 36 citations

Tissue specific expression of PKR protein kinase in aging B6D2F1 mice

2000 • 29 citations

Immunoreactive insulin content of 203 pancreases from foetuses of healthy mothers

1970 • 28 citations

The Role of Calcium in the Regulation of Protein Synthesis in the Exocrine Pancreas

1997 • 11 citations

Chapter 12 Reconstitution of Secretory Protein Translocation from Detergent-Solubilized Rough Microsomes

1991 • 10 citations