Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response

Inflammation, Atherosclerosis, and Coronary Artery Disease

2005 • 8,367 citations

Acute-Phase Proteins and Other Systemic Responses to Inflammation

1999 • 6,324 citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

C-Reactive Protein and Other Circulating Markers of Inflammation in the Prediction of Coronary Heart Disease

2004 • 2,914 citations

C-Reactive Protein Levels and Outcomes after Statin Therapy

2005 • 2,249 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

Decoding the Patterns of Self and Nonself by the Innate Immune System

2002 • 2,096 citations

CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals

1999 • 2,076 citations

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

2003 • 1,979 citations

Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress

1999 • 1,954 citations

ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

2000 • 1,764 citations

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

2003 • 1,515 citations

ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals

2002 • 1,368 citations

Statin Therapy, LDL Cholesterol, C-Reactive Protein, and Coronary Artery Disease

2005 • 1,316 citations

Regulated Intramembrane Proteolysis

2000 • 1,314 citations

Identification of the cis-Acting Endoplasmic Reticulum Stress Response Element Responsible for Transcriptional Induction of Mammalian Glucose-regulated Proteins

1998 • 1,216 citations

Orchestrating the unfolded protein response in health and disease

2002 • 1,163 citations

Orchestrating the unfolded protein response in health and disease

2002 • 966 citations

A Time-Dependent Phase Shift in the Mammalian Unfolded Protein Response

2003 • 670 citations

Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.

2000 • 551 citations

Sterol-Regulated Release of SREBP-2 from Cell Membranes Requires Two Sequential Cleavages, One Within a Transmembrane Segment

1996 • 515 citations

Activation of ATF6 and an ATF6 DNA Binding Site by the Endoplasmic Reticulum Stress Response

2000 • 485 citations

Complementation Cloning of , a Gene Encoding a Putative Metalloprotease Required for Intramembrane Cleavage of SREBPs

1997 • 453 citations

Infection and Inflammation‐Induced Proatherogenic Changes of Lipoproteins

2000 • 400 citations

Molecular Identification of the Sterol-Regulated Luminal Protease that Cleaves SREBPs and Controls Lipid Composition of Animal Cells

1998 • 400 citations

C-Reactive Protein Accelerates the Progression of Atherosclerosis in Apolipoprotein E–Deficient Mice

2004 • 380 citations

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

2001 • 328 citations

Transport-Dependent Proteolysis of SREBP

1999 • 316 citations

OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes

2005 • 286 citations

Genetic Interactions Due to Constitutive and Inducible Gene Regulation Mediated by the Unfolded Protein Response in C. elegans

2005 • 248 citations

Cleavage of Sterol Regulatory Element-binding Proteins (SREBPs) at Site-1 Requires Interaction with SREBP Cleavage-activating Protein

1998 • 215 citations

Bioengineering of coagulation factor VIII for improved secretion

2004 • 205 citations

CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression

2001 • 158 citations

Comparison of the Associations of Apolipoprotein B and Non-High-Density Lipoprotein Cholesterol With Other Cardiovascular Risk Factors in Patients With the Metabolic Syndrome in the Insulin Resistance Atherosclerosis Study

2004 • 139 citations

Luman, the Cellular Counterpart of Herpes Simplex Virus VP16, Is Processed by Regulated Intramembrane Proteolysis

2002 • 134 citations

Innate and acquired immunity intersect in a global view of the acute-phase response

2003 • 102 citations

The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma

2005 • 99 citations

Activation of Mammalian Unfolded Protein Response Is Compatible with the Quality Control System Operating in the Endoplasmic Reticulum

2004 • 97 citations

Isolation of Cholesterol-requiring Mutant Chinese Hamster Ovary Cells with Defects in Cleavage of Sterol Regulatory Element-binding Proteins at Site 1

1998 • 95 citations

Dynamic Regulation of Cyclooxygenase-2 Promoter Activity by Isoforms of CCAAT/Enhancer-binding Proteins

2002 • 95 citations

Biosynthesis and Enzymatic Characterization of Human SKI-1/S1P and the Processing of Its Inhibitory Prosegment

2000 • 87 citations

Secreted Site-1 Protease Cleaves Peptides Corresponding to Luminal Loop of Sterol Regulatory Element-binding Proteins

1999 • 74 citations

ROLE OF STAT3 AND C/EBP IN CYTOKINE-DEPENDENT EXPRESSION OF THE MOUSE SERUM AMYLOID P-COMPONENT (SAP) AND C-REACTIVE PROTEIN (CRP) GENES

2000 • 52 citations

Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change

2005 • 41 citations