ER stress and SREBP-1 activation are implicated in β-cell glucolipotoxicity

Role of AMP-activated protein kinase in mechanism of metformin action

2001 • 5,086 citations

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

2002 • 4,142 citations

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

2003 • 3,886 citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

2004 • 3,671 citations

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

2002 • 3,652 citations

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

2000 • 1,764 citations

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

2003 • 1,350 citations

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

1992 • 1,128 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.

1996 • 1,004 citations

Uncoupling Protein-2 Negatively Regulates Insulin Secretion and Is a Major Link between Obesity, β Cell Dysfunction, and Type 2 Diabetes

2001 • 916 citations

β-Cell-specific inactivation of the mouseIpf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes

1998 • 901 citations

Lipotoxic Diseases

2002 • 835 citations

Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice

2000 • 805 citations

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

1999 • 771 citations

Minireview: Secondary β-Cell Failure in Type 2 Diabetes—A Convergence of Glucotoxicity and Lipotoxicity

2002 • 735 citations

Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

2004 • 721 citations

Increased Levels of Nuclear SREBP-1c Associated with Fatty Livers in Two Mouse Models of Diabetes Mellitus

1999 • 697 citations

Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways

2001 • 696 citations

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

2002 • 694 citations

Metformin reverses fatty liver disease in obese, leptin-deficient mice

2000 • 680 citations

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

2002 • 588 citations

ADD1: a Novel Helix-Loop-Helix Transcription Factor Associated with Adipocyte Determination and Differentiation

1993 • 575 citations

Free Fatty Acids and Cytokines Induce Pancreatic β-Cell Apoptosis by Different Mechanisms: Role of Nuclear Factor-κB and Endoplasmic Reticulum Stress

2004 • 560 citations

Ethanol Induces Fatty Acid Synthesis Pathways by Activation of Sterol Regulatory Element-binding Protein (SREBP)

2002 • 505 citations

Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release.

1983 • 466 citations

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover.

2001 • 465 citations

Regulation of fatty acid homeostasis in cells: Novel role of leptin

1999 • 442 citations

Beta-cell adaptation and decompensation during the progression of diabetes.

2001 • 438 citations

Hepatic Glucokinase Is Required for the Synergistic Action of ChREBP and SREBP-1c on Glycolytic and Lipogenic Gene Expression

2004 • 429 citations

Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance

2002 • 408 citations

Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription

2004 • 388 citations

Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver

2004 • 378 citations

Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse

2004 • 373 citations

A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids

1999 • 364 citations

Glucose and Tolbutamide Induce Apoptosis in Pancreatic β-Cells

1998 • 363 citations

Absence of Sterol Regulatory Element-binding Protein-1 (SREBP-1) Ameliorates Fatty Livers but Not Obesity or Insulin Resistance in Lep/Lep Mice

2002 • 359 citations

ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation.

1993 • 351 citations

Role of Sterol Regulatory Element-binding Protein 1 in Regulation of Renal Lipid Metabolism and Glomerulosclerosis in Diabetes Mellitus

2002 • 327 citations

SREBPs suppress IRS-2-mediated insulin signalling in the liver

2004 • 310 citations

Dysregulation of insulin receptor substrate 2 in β cells and brain causes obesity and diabetes

2004 • 297 citations

Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA).

1988 • 284 citations

Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets

2000 • 265 citations

Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis

2004 • 246 citations

Uncoupling Protein 2: A Possible Link Between Fatty Acid Excess and Impaired Glucose-Induced Insulin Secretion?

2001 • 232 citations

Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus

2004 • 230 citations

HIV Protease Inhibitor Induces Fatty Acid and Sterol Biosynthesis in Liver and Adipose Tissues Due to the Accumulation of Activated Sterol Regulatory Element-binding Proteins in the Nucleus

2001 • 217 citations

Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet

2002 • 215 citations

Free Fatty Acid-induced β-Cell Defects Are Dependent on Uncoupling Protein 2 Expression

2004 • 202 citations

Insulin-Independent Induction of Sterol Regulatory Element-Binding Protein-1c Expression in the Livers of Streptozotocin-Treated Mice

2004 • 189 citations

Insulin-secreting β-Cell Dysfunction Induced by Human Lipoproteins

2003 • 184 citations

Pdx1 Level Defines Pancreatic Gene Expression Pattern and Cell Lineage Differentiation

2001 • 166 citations

Uncoupling Protein 2 and Islet Function

2004 • 159 citations

Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta -cell line

1998 • 155 citations

Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression.

1998 • 147 citations

Antecedent Hyperglycemia, Not Hyperlipidemia, Is Associated With Increased Islet Triacylglycerol Content and Decreased Insulin Gene mRNA Level in Zucker Diabetic Fatty Rats

2001 • 144 citations

Increased Expression of the Sterol Regulatory Element-binding Protein-1 Gene in Insulin Receptor Substrate-2−/−Mouse Liver

2001 • 137 citations

Modulation of glucose responsiveness of insulinoma β-cells by graded overexpression of glucokinase

1997 • 126 citations

Regulation of the Uncoupling Protein-2 Gene in INS-1 β-Cells by Oleic Acid

2002 • 119 citations

Adiponectin Ameliorates Dyslipidemia Induced by the Human Immunodeficiency Virus Protease Inhibitor Ritonavir in Mice

2003 • 114 citations

Cloning and Characterization of the Human Stearoyl-CoA Desaturase Gene Promoter: Transcriptional Activation by Sterol Regulatory Element Binding Protein and Repression by Polyunsaturated Fatty Acids and Cholesterol

2001 • 112 citations

Critical Role for Cataplerosis via Citrate in Glucose-Regulated Insulin Release

2002 • 112 citations

SREBF-1 Gene Polymorphisms Are Associated With Obesity and Type 2 Diabetes in French Obese and Diabetic Cohorts

2004 • 112 citations

Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats

2004 • 109 citations

Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)

2004 • 107 citations

Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion

1998 • 99 citations

Glucose Stimulates the Activity of the Guanine Nucleotide-exchange Factor eIF-2B in Isolated Rat Islets of Langerhans

1996 • 93 citations

ChREBP Rather than USF2 Regulates Glucose Stimulation of Endogenous L-pyruvate Kinase Expression in Insulin-secreting Cells

2002 • 93 citations

The Transcription Factor SREBP-1c Is Instrumental in the Development of औ-Cell Dysfunction

2003 • 91 citations

Transgenic Mice Overexpressing Nuclear SREBP-1c in Pancreatic β-Cells

2005 • 88 citations

Modulating the transcriptional control of adipogenesis

1997 • 83 citations

Role of Uncoupling Protein-2 Up-Regulation and Triglyceride Accumulation in Impaired Glucose-Stimulated Insulin Secretion in a β-Cell Lipotoxicity Model Overexpressing Sterol Regulatory Element-Binding Protein-1c

2004 • 83 citations

GAD65-mediated Glutamate Decarboxylation Reduces Glucose-stimulated Insulin Secretion in Pancreatic Beta Cells

2001 • 82 citations

Stimulation of Acetyl-CoA Carboxylase Gene Expression by Glucose Requires Insulin Release and Sterol Regulatory Element Binding Protein 1c in Pancreatic MIN6 β-Cells

2002 • 66 citations

Genetic Variants in Human Sterol Regulatory Element Binding Protein-1c in Syndromes of Severe Insulin Resistance and Type 2 Diabetes

2004 • 59 citations

Glucose-stimulated Protein Synthesis in Pancreatic β-Cells Parallels an Increase in the Availability of the Translational Ternary Complex (eIF2-GTP·Met-tRNAi) and the Dephosphorylation of eIF2α

2004 • 54 citations

SREBP-1 Dimerization Specificity Maps to Both the Helix-Loop-Helix and Leucine Zipper Domains

2004 • 38 citations

Glucose Regulates EF-2 Phosphorylation and Protein Translation by a Protein Phosphatase-2A-dependent Mechanism in INS-1-derived 832/13 Cells

2003 • 31 citations