ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Live or let die: the cell's response to p53

2002 • 3,138 citations

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

2004 • 1,854 citations

Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State

2001 • 1,840 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

2003 • 1,298 citations

Orchestrating the unfolded protein response in health and disease

2002 • 1,163 citations

Ca ²⁺ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD

1999 • 1,136 citations

The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

1999 • 1,045 citations

BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

2000 • 1,033 citations

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

2000 • 983 citations

Orchestrating the unfolded protein response in health and disease

2002 • 966 citations

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

2003 • 862 citations

Calcium Signaling Mechanisms in T Lymphocytes

2001 • 841 citations

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death

2004 • 813 citations

Translational control in the endoplasmic reticulum stress response

2002 • 783 citations

A one-step purification of membrane proteins using a high efficiency immunomatrix.

1982 • 782 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

2002 • 699 citations

Translational control in the endoplasmic reticulum stress response

2002 • 686 citations

Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis

2001 • 620 citations

Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

2002 • 564 citations

A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes.

1977 • 553 citations

Endoplasmic Reticulum Stress-induced Apoptosis

2006 • 490 citations

Gene expression during ER stress–induced apoptosis in neurons

2003 • 361 citations

Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice

2006 • 317 citations

Differential Inhibition and Posttranslational Modification of Protein Phosphatase 1 and 2A in MCF7 Cells Treated with Calyculin-A, Okadaic Acid, and Tautomycin

1997 • 304 citations

Regulatory phosphorylation of Bim: sorting out the ERK from the JNK

2005 • 303 citations

Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells

2003 • 296 citations

Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis

2004 • 241 citations

A Serine Protease Inhibitor Prevents Endoplasmic Reticulum Stress-induced Cleavage but Not Transport of the Membrane-bound Transcription Factor ATF6

2003 • 204 citations

The PP2A-Associated Protein α4 Is an Essential Inhibitor of Apoptosis

2004 • 148 citations

Gene structure, alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim

2001 • 140 citations

Endoplasmic reticulum storage diseases

2002 • 128 citations

Pin1 Mediates Neural-Specific Activation of the Mitochondrial Apoptotic Machinery

2006 • 76 citations