The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients

Mechanisms linking obesity to insulin resistance and type 2 diabetes

2006 • 4,896 citations

Roles of CHOP/GADD153 in endoplasmic reticulum stress

2003 • 2,663 citations

Obesity and Diabetes in the Developing World — A Growing Challenge

2007 • 2,138 citations

ER stress and the unfolded protein response

2004 • 1,696 citations

Islet cell failure in type 2 diabetes

2006 • 1,597 citations

Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes

2005 • 1,413 citations

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

2001 • 1,204 citations

Five Stages of Evolving Beta-Cell Dysfunction During Progression to Diabetes

2004 • 1,032 citations

Chronic Oxidative Stress as a Central Mechanism for Glucose Toxicity in Pancreatic Islet Beta Cells in Diabetes

2004 • 1,017 citations

Endoplasmic Reticulum Stress Signaling in Disease

2006 • 914 citations

Epidemiologic and economic consequences of the global epidemics of obesity and diabetes

2006 • 883 citations

Type 2 Diabetes-a Matter of ß-Cell Life and Death?

2005 • 881 citations

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

2007 • 799 citations

Prolonged Exposure to Free Fatty Acids Has Cytostatic and Pro-Apoptotic Effects on Human Pancreatic Islets

2002 • 596 citations

Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway

2001 • 594 citations

Free Fatty Acids and Cytokines Induce Pancreatic β-Cell Apoptosis by Different Mechanisms: Role of Nuclear Factor-κB and Endoplasmic Reticulum Stress

2004 • 560 citations

Diagnosis and Classification of Diabetes Mellitus

2006 • 559 citations

Chronic Palmitate But Not Oleate Exposure Induces Endoplasmic Reticulum Stress, Which May Contribute to INS-1 Pancreatic β-Cell Apoptosis

2006 • 556 citations

A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse

1999 • 555 citations

Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells.

2002 • 516 citations

Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca2+ ATPase 2b and Deplete Endoplasmic Reticulum Ca2+, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells

2005 • 505 citations

Functional and Molecular Defects of Pancreatic Islets in Human Type 2 Diabetes

2005 • 459 citations

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications

2004 • 419 citations

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

2005 • 408 citations

High Expression Rates of Human Islet Amyloid Polypeptide Induce Endoplasmic Reticulum Stress–Mediated β-Cell Apoptosis, a Characteristic of Humans With Type 2 but Not Type 1 Diabetes

2007 • 392 citations

Structural and Functional Abnormalities in the Islets Isolated From Type 2 Diabetic Subjects

2004 • 348 citations

Pancreatic Islets from Type 2 Diabetic Patients Have Functional Defects and Increased Apoptosis That Are Ameliorated by Metformin

2004 • 325 citations

Selective Inhibition of Eukaryotic Translation Initiation Factor 2α Dephosphorylation Potentiates Fatty Acid-induced Endoplasmic Reticulum Stress and Causes Pancreatic β-Cell Dysfunction and Apoptosis

2006 • 285 citations

ER stress and SREBP-1 activation are implicated in β-cell glucolipotoxicity

2005 • 257 citations

Beta cell function and its relation to insulin action in humans: a critical appraisal

2004 • 257 citations

Impaired Gene and Protein Expression of Exocytotic Soluble N-Ethylmaleimide Attachment Protein Receptor Complex Proteins in Pancreatic Islets of Type 2 Diabetic Patients

2006 • 225 citations

Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes.

2000 • 214 citations

ER stress signaling by regulated splicing: IRE1/HAC1/XBP1

2005 • 213 citations

Impact of Endoplasmic Reticulum Stress Pathway on Pancreatic β-Cells and Diabetes Mellitus

2003 • 179 citations

The HNF-1 target Collectrin controls insulin exocytosis by SNARE complex formation

2005 • 149 citations

Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs

2007 • 130 citations

Mechanism of Class 1 (Glycosylhydrolase Family 47) α-Mannosidases Involved in N-Glycan Processing and Endoplasmic Reticulum Quality Control

2005 • 112 citations

Enzymatic, metabolic and secretory patterns in human islets of Type 2 (non-insulin-dependent) diabetic patients

1994 • 95 citations

Synthetic Substrates for an Endoplasmic Reticulum Protein‐Folding Sensor, UDP‐Glucose: Glycoprotein Glucosyltransferase

2005 • 92 citations

When Translation Meets Metabolism: Multiple Links to Diabetes

2003 • 88 citations

Misfolded proinsulin accumulates in expanded pre‐Golgi intermediates and endoplasmic reticulum subdomains in pancreatic beta cells of Akita mice

2004 • 78 citations

Wolcott‐Rallison syndrome: a clinical and genetic study of three children, novel mutation in EIF2AK3 and a review of the literature

2004 • 62 citations

Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection

2006 • 62 citations

The ER Glycoprotein Quality Control System

2004 • 48 citations

Pulsatile Insulin Release From Islets Isolated From Three Subjects With Type 2 Diabetes

2002 • 42 citations

The Diabetes-Prone NZO/Hl Strain. II. Pancreatic Immunopathology

2002 • 30 citations

Blood Glucose-Lowering Nuclear Receptor Agonists Only Partially Normalize Hepatic Gene Expression in db/db Mice

2005 • 27 citations

Post mortem changes in Ca2+ transporting proteins of sarcoplasmic reticulum in dependence on malignant hyperthermia status in pigs.

1999 • 24 citations

Ultrastructural Study of the Pancreas in AIDS

2003 • 6 citations