Palindrome with Spacer of One Nucleotide Is Characteristic of the cis-Acting Unfolded Protein Response Element inSaccharomyces cerevisiae

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KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 gene

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S. cerevisiae encodes an essential protein homologous in sequence and function to mammalian BiP

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A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins.

1992 • 375 citations

Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic‐leucine zipper motif is required for the unfolded protein‐response pathway

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The Promoter Region of the Yeast KAR2 (BiP) Gene Contains a Regulatory Domain that Responds to the Presence of Unfolded Proteins in the Endoplasmic Reticulum

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The endoplasmic reticulum as a protein-folding compartment

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A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s.

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Saccharomyces cerevisiae IRE2/HAC1 is involved in IRE1-mediated KAR2 expression

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Unconventional Splicing of HAC1/ERN4 mRNA Required for the Unfolded Protein Response

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The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum.

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SSI1 Encodes a Novel Hsp70 of the Saccharomyces cerevisiae Endoplasmic Reticulum

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Product of SEC53 is required for folding and glycosylation of secretory proteins in the lumen of the yeast endoplasmic reticulum.

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Molecular Structure of a Yeast Gene, PDI1, Encoding Protein Disulfide Isomerase That Is Essential for Cell Growth

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A novel subfamily of Hsp70s in the endoplasmic reticulum

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Two redundant systems maintain levels of resident proteins within the yeast endoplasmic reticulum.

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The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII

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