Interferon-γ potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

2003 • 3,079 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

Roles of CHOP/GADD153 in endoplasmic reticulum stress

2003 • 2,663 citations

Endoplasmic reticulum stress: cell life and death decisions

2005 • 2,197 citations

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

2003 • 1,979 citations

A trip to the ER: coping with stress

2003 • 1,330 citations

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

2001 • 1,204 citations

A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis

2001 • 880 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 858 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 724 citations

Two Distinct Stress Signaling Pathways Converge Upon the CHOP Promoter During the Mammalian Unfolded Protein Response

2002 • 666 citations

Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway

2001 • 594 citations

Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

2002 • 560 citations

Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.

2000 • 551 citations

Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca2+ ATPase 2b and Deplete Endoplasmic Reticulum Ca2+, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells

2005 • 505 citations

Activation of ATF6 and an ATF6 DNA Binding Site by the Endoplasmic Reticulum Stress Response

2000 • 485 citations

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

1988 • 476 citations

The ER function BiP is a master regulator of ER function.

2004 • 439 citations

ER chaperone functions during normal and stress conditions

2004 • 414 citations

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

2005 • 408 citations

Endoplasmic Reticulum Chaperones GRP78 and Calreticulin Prevent Oxidative Stress, Ca2+ Disturbances, and Cell Death in Renal Epithelial Cells

1997 • 370 citations

ENDOPLASMIC RETICULUM–ASSOCIATED DEGRADATION

2005 • 366 citations

Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program.

1996 • 279 citations

Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells

1988 • 266 citations

Expression of adiponectin receptors in pancreatic β cells

2003 • 266 citations

Endoplasmic reticulum contains a common, abundant calcium-binding glycoprotein, endoplasmin

1986 • 236 citations

Identification of Novel Cytokine-Induced Genes in Pancreatic β-Cells by High-Density Oligonucleotide Arrays

2001 • 231 citations

Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells

2003 • 224 citations

Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells

1998 • 219 citations

Pancreatic β-Cell Failure and Diabetes in Mice With a Deletion Mutation of the Endoplasmic Reticulum Molecular Chaperone Gene P58IPK

2005 • 207 citations

Endoplasmic Reticulum Stress Proteins Block Oxidant-induced Ca2+ Increases and Cell Death

1998 • 193 citations

IL-1β and IFN-γ induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice

2003 • 192 citations

Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-γ

2005 • 185 citations

Specific inhibitors of intracellular Ca2+ transport ATPases

1994 • 162 citations

Toll-like Receptor 3 and STAT-1 Contribute to Double-stranded RNA+ Interferon-γ-induced Apoptosis in Primary Pancreatic β-Cells

2005 • 157 citations

Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane

1999 • 147 citations

Expression of the endoplasmic reticulum molecular chaperone (ORP150) rescues hippocampal neurons from glutamate toxicity

2001 • 133 citations

The protein translocation channel binds proteasomes to the endoplasmic reticulum membrane

2005 • 110 citations

Global profiling of double stranded RNA- and IFN-?-induced genes in rat pancreatic beta cells

2003 • 66 citations

GRP94 reduces cell death in SH-SY5Y cells perturbated calcium homeostasis

2004 • 46 citations

Effect of Interferon-γ and Glucose on Major Histocompatibility Complex Class I and Class II Expression by Pancreatic β- and Non-β-Cells¹

1997 • 43 citations

Double-Stranded Ribonucleic Acid (RNA) Induces β-Cell Fas Messenger RNA Expression and Increases Cytokine-Induced β-Cell Apoptosis*

2001 • 40 citations

ORP150 ameliorates ischemia/reperfusion injury from middle cerebral artery occlusion in mouse brain

2004 • 33 citations

Cytoprotection Following Endoplasmic Reticulum Stress Protein Induction in Continuous Cell Lines

2004 • 32 citations

Loading neurons with BAPTA-AM activates xbp1 processing indicative of induction of endoplasmic reticulum stress

2003 • 32 citations

Abundant Expression of 150-kDa Oxygen-Regulated Protein in Mouse Pancreatic Beta Cells Is Correlated with Insulin Secretion

2000 • 22 citations

Effect on insulin production sorting and secretion by major histocompatibility complex class II gene expression in the pancreatic beta-cell of transgenic mice.

1992 • 12 citations