Conditional and specific NF-κB blockade protects pancreatic beta cells from diabetogenic agents

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NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

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Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

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The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas

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NF-κB at the crossroads of life and death

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Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

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Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes

2005 • 1,413 citations

Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells

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Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues

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Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus

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β-Cell death during progression to diabetes

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A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis

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The Beginning of the End: IκB Kinase (IKK) and NF-κB Activation

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CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse

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An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus

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STZ Transport and Cytotoxicity: Specific Enhancement in GLUT2-Expressing Cells

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Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans.

1993 • 397 citations

Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin

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β cell apoptosis in T cell-mediated autoimmune diabetes

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The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells

1996 • 304 citations

Cytokines Induce Deoxyribonucleic Acid Strand Breaks and Apoptosis in Human Pancreatic Islet Cells*

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A Comprehensive Analysis of Cytokine-induced and Nuclear Factor-κB-dependent Genes in Primary Rat Pancreatic β-Cells

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Isolated mouse pancreatic islets in culture: Effects of serum and different culture media on the insulin production of the islets

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Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation

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Inhibition of Cytokine-Induced NF-κB Activation by Adenovirus-Mediated Expression of a NF-κB Super-Repressor Prevents β-Cell Apoptosis

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Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells

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Biochemical Evidence for Nitric Oxide Formation from Streptozotocin in Isolated Pancreatic Islets

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Protection of Human Islets from the Effects of Interleukin-1β by Adenoviral Gene Transfer of an IκB Repressor

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Apoptosis Is the Mode of β-Cell Death Responsible for the Development of IDDM in the Nonobese Diabetic (NOD) Mouse

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Rapid Reversal of the Diabetic Endothelial Dysfunction by Pharmacological Inhibition of Poly(ADP-Ribose) Polymerase

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BETA-CELL APOPTOSIS IS RESPONSIBLE FOR THE DEVELOPMENT OF IDDM IN THE MULTIPLE LOW-DOSE STREPTOZOTOCIN MODEL

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Cytokines Cause Functional and Structural Damage to Isolated Islets of Langerhans

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Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes.

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High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-κB activation

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Pancreatic beta cells in insulin‐dependent diabetes

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Nuclear Factor-κB Activity in β-Cells Is Required for Glucose-Stimulated Insulin Secretion

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Streptozotocin-induced pancreatic insulitis in mice. Morphologic and physiologic studies.

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A Pancreatic β-Cell-specific Enhancer in the HumanPDX-1 Gene Is Regulated by Hepatocyte Nuclear Factor 3β (HNF-3β), HNF-1α, and SPs Transcription Factors

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Contribution of ductal cells to cytokine responses by human pancreatic islets.

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Correction of Hyperglycemia in Diabetic Mice Transplanted with Reversibly Immortalized Pancreatic β Cells Controlled by the tet-on Regulatory System

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Distinction Between Interleukin-1–Induced Necrosis and Apoptosis of Islet Cells

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Transcriptional Regulation of Type I Diabetes by NF-κB

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The Beta Cell in Autoimmune Diabetes: Many Mechanisms and Pathways of Loss

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Expression of a Dominant Negative Inhibitor of NF-κB Protects MIN6 β-Cells from Cytokine-Induced Apoptosis

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Endothelial cells as cytotoxic effector cells: cytokine-activated rat islet endothelial cells lyse syngeneic islet cells via nitric oxide

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NFkappaB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes

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B-cell apoptosis in T-cell-mediated autoimmune diabetes

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Generation of Nitric Oxide from Streptozotocin (STZ) in the Presence of Copper(II) plus Ascorbate: Implication for the Development of STZ-Induced Diabetes

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Generation of Monoclonal Antibodies Against Mouse Neurogenin 3: A New Immunocytochemical Tool to Study the Pancreatic Endocrine Progenitor Cell

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Decrease in insulin-containing secretory granules and mitochondrial gene expression in mouse pancreatic islets maintained in culture following streptozotocin exposure

1991 • 18 citations