Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Data up to Jan 2025
Total Citations Per Year
Abstract
References (50)
Obesity is associated with macrophage accumulation in adipose tissue
2003 • 8,349 citations
Obesity is associated with macrophage accumulation in adipose tissue
2003 • 7,795 citations
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
1993 • 7,219 citations
Prevalence of Obesity, Diabetes, and Obesity-Related Health Risk Factors, 2001
2003 • 5,872 citations
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
2003 • 5,744 citations
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
2003 • 5,391 citations
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
2001 • 4,289 citations
Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents
2013 • 2,971 citations
Suppression of TNF-α-Induced Apoptosis by NF-κB
1996 • 2,623 citations
Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ
2001 • 1,849 citations
Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes
2003 • 1,435 citations
IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice
2004 • 1,267 citations
Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction
2002 • 1,264 citations
Fat Accumulation in the Liver Is Associated with Defects in Insulin Suppression of Glucose Production and Serum Free Fatty Acids Independent of Obesity in Normal Men
2002 • 1,057 citations
Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes
2002 • 1,053 citations
Is Type II diabetes mellitus a disease of the innate immune system?
1998 • 1,040 citations
Interleukin-6 (IL-6) Induces Insulin Resistance in 3T3-L1 Adipocytes and Is, Like IL-8 and Tumor Necrosis Factor-α, Overexpressed in Human Fat Cells from Insulin-resistant Subjects
2003 • 1,014 citations
Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation
1999 • 855 citations
Introns increase transcriptional efficiency in transgenic mice.
1988 • 733 citations
A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis
2004 • 729 citations
Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone
2003 • 716 citations
Inflammatory pathways and insulin action
2003 • 716 citations
Prevention of fat-induced insulin resistance by salicylate
2001 • 713 citations
Potential Role of TNF-α in the Pathogenesis of Insulin Resistance and Type 2 Diabetes
2000 • 692 citations
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes
2002 • 614 citations
Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.
1993 • 543 citations
NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176
1998 • 533 citations
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes
2002 • 529 citations
Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo
2004 • 526 citations
Chronic Exposure to Interleukin-6 Causes Hepatic Insulin Resistance in Mice
2003 • 477 citations
Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance
2003 • 447 citations
Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients.
2000 • 435 citations
Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance
2003 • 425 citations
Strategies of Anti‐Cytokine Monoclonal Antibody Development: Immunoassay of IL‐10 and IL‐5 in Clinical Samples
1992 • 384 citations
Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone
2003 • 360 citations
Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone
2003 • 359 citations
Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB
1995 • 351 citations
Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-alpha challenge in mice.
1990 • 343 citations
Troglitazone action is independent of adipose tissue.
1997 • 340 citations
IκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex
1999 • 333 citations
Insulin Sensitivity and Its Measurement: Structural Commonalities among the Methods1
2000 • 293 citations
Interleukin 1? and interleukin 6, but not tumor necrosis factor ?, inhibit insulin-stimulated glycogen synthesis in rat hepatocytes
1998 • 135 citations
Treatment of B-lymphoproliferative disorder with a monoclonal anti-interleukin-6 antibody in 12 patients: a multicenter phase 1-2 clinical trial
2001 • 133 citations
Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance
2004 • 97 citations
Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance
2004 • 78 citations
[25] Signaling pathways leading to nuclear factor-κB activation
2000 • 49 citations
JMM - Past and Present
2002 • 30 citations
Invited comment on W. Ebstein: On the therapy of diabetes mellitus, in particular on the application of sodium salicylate.
2002 • 29 citations
Inflammation and Its Relationship to Insulin Resistance, Type 2 Diabetes Mellitus, and Endothelial Dysfunction
2003 • 25 citations
Invited comment on W. Ebstein: On the therapy of diabetes mellitus, in particular on the application of sodium salicylate
2002 • 15 citations
Cited By (0)
No citing papers found in database