A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

PCR protocols — A guide to methods and applications

1990 • 12,897 citations

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

Protein folding in the cell

1992 • 4,138 citations

An hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

1986 • 1,457 citations

Global Estimates for Prevalence of Diabetes Mellitus and Impaired Glucose Tolerance in Adults

1993 • 928 citations

Intranuclear Inclusions of Expanded Polyglutamine Protein in Spinocerebellar Ataxia Type 3

1997 • 821 citations

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

1983 • 659 citations

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

1997 • 556 citations

AN IMPROVED METHOD FOR ISOLATION OF MOUSE PANCREATIC ISLETS

1985 • 548 citations

ER Quality Control: The Cytoplasmic Connection

1997 • 528 citations

A Novel Locus, Mody4, Distal to D7Mit189 on Chromosome 7 Determines Early-Onset NIDDM in Nonobese C57BL/6 (Akita) Mutant Mice

1997 • 506 citations

Direct identification of prohormone conversion site in insulin-secreting cells

1985 • 297 citations

Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells.

1996 • 279 citations

Protein Disulfide Isomerase and Assisted Protein Folding

1997 • 269 citations

Characterization of the two nonallelic genes encoding mouse preproinsulin

1986 • 165 citations

Scope and Heterogeneous Nature of MODY

1990 • 156 citations

Lessons Learned From Molecular Biology of Insulin-Gene Mutations

1990 • 154 citations

A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway.

1988 • 135 citations

Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period.

1998 • 96 citations

Contrasting of Lowicryl K4M thin sections

1990 • 73 citations

Proteolytic Processing of Pro-opiomelanocortin Occurs in Acidifying Secretory Granules of AtT-20 Cells

1997 • 60 citations

Developmental expression of proprotein-processing endoprotease furin in rat pancreatic islets.

1996 • 13 citations