Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes

1980 • 1,884 citations

An hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

1986 • 1,457 citations

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

1988 • 1,292 citations

Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.

1980 • 903 citations

Expression of wild-type and mutant forms of influenza hemagglutinin: The role of folding in intracellular transport

1986 • 879 citations

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

1989 • 763 citations

Structure and expression of the human gene encoding major heat shock protein HSP70.

1985 • 461 citations

Initiation of protein synthesis by internal entry of ribosomes into the 5' nontranslated region of encephalomyocarditis virus RNA in vivo

1989 • 417 citations

Human CSF-1: Molecular Cloning and Expression of 4-kb cDNA Encoding the Human Urinary Protein

1987 • 381 citations

Expression of recombinant plasmids in mammalian cells Is enhanced by sodium butyrate

1983 • 380 citations

Thermal response of rat fibroblasts stably transfected with the human 70-kDa heat shock protein-encoding gene.

1991 • 365 citations

The relationship of N-linked glycosylation and heavy chain-binding protein association with the secretion of glycoproteins.

1987 • 357 citations

Folding, interaction with GRP78-BiP, assembly, and transport of the human immunodeficiency virus type 1 envelope protein

1991 • 333 citations

A large region (approximately equal to 95 kDa) of human factor VIII is dispensable for in vitro procoagulant activity.

1986 • 314 citations

Interactions of misfolded influenza virus hemagglutinin with binding protein (BiP).

1989 • 312 citations

Improved vectors for stable expression of foreign genes in mammalian cells by use of the untranslated leader sequence from EMC virus

1991 • 265 citations

Increased synthesis of secreted proteins induces expression of glucose-regulated proteins in butyrate-treated Chinese hamster ovary cells

1989 • 261 citations

Complex regulation of heat shock- and glucose-responsive genes in human cells.

1988 • 242 citations

Structure of pre-pro-von Willebrand factor and its expression in heterologous cells

1986 • 212 citations

Identity of the immunoglobulin heavy-chain-binding protein with the 78,000-dalton glucose-regulated protein and the role of posttranslational modifications in its binding function.

1988 • 211 citations

The stress response in Chinese hamster ovary cells. Regulation of ERp72 and protein disulfide isomerase expression and secretion.

1990 • 186 citations

[42] Selection and coamplification of heterologous genes in mammalian cells

1990 • 184 citations

Heavy chain binding protein recognizes incompletely disulfide-bonded forms of vesicular stomatitis virus G protein.

1990 • 180 citations

Effect of von Willebrand factor coexpression on the synthesis and secretion of factor VIII in Chinese hamster ovary cells.

1989 • 178 citations

Interaction of heavy chain binding protein (BiP/GRP78) with adenine nucleotides.

1989 • 176 citations

Intracellular maturation and transport of the SV5 type II glycoprotein hemagglutinin-neuraminidase: specific and transient association with GRP78-BiP in the endoplasmic reticulum and extensive internalization from the cell surface.

1989 • 159 citations

Structure and Expression of the Human Gene Encoding Major Heat Shock Protein HSP70

1985 • 155 citations

Reduction of Endogenous GRP78 Levels Improves Secretion of a Heterologous Protein in CHO Cells

1988 • 152 citations

Protein dissociation from GRP78 and secretion are blocked by depletion of cellular ATP levels.

1990 • 147 citations

Rat gene encoding the 78-kDa glucose-regulated protein GRP78: its regulatory sequences and the effect of protein glycosylation on its expression.

1987 • 144 citations

Glucose-regulated protein (GRP94 and GRP78) genes share common regulatory domains and are coordinately regulated by common trans-acting factors.

1989 • 130 citations

Transcriptional regulation of two genes specifically induced by glucose starvation in a hamster mutant fibroblast cell line.

1983 • 128 citations

Accumulation of the insoluble PiZ variant of human alpha 1-antitrypsin within the hepatic endoplasmic reticulum does not elevate the steady-state level of grp78/BiP

1990 • 121 citations

Structure and assembly of the endoplasmic reticulum. The synthesis of three major endoplasmic reticulum proteins during lipopolysaccharide-induced differentiation of murine lymphocytes.

1985 • 107 citations

The nucleotide sequence encoding the hamster 78-kDa glucose-regulated protein (GRP78) and its conservation between hamster and rat

1987 • 93 citations

Complex Regulation of Heat Shock- and Glucose-Responsive Genes in Human Cells

1988 • 77 citations

Identity of the Immunoglobulin Heavy-Chain-Binding Protein with the 78,000-Dalton Glucose-Regulated Protein and the Role of Posttranslational Modifications in Its Binding Function

1988 • 73 citations

[44] Analysis of synthesis, processing, and secretion of proteins expressed in mammalian cells

1990 • 65 citations

ADP‐ribosylation of the 78‐kDa glucose‐regulated protein during nutritional stress

1989 • 62 citations

A2 domain of human recombinant-derived factor VIII is required for procoagulant activity but not for thrombin cleavage

1992 • 51 citations

Effect of von Willebrand Factor Coexpression on the Synthesis and Secretion of Factor VIII in Chinese Hamster Ovary Cells

1989 • 33 citations

Glucose-Regulated Protein (GRP94 and GRP78) Genes Share Common Regulatory Domains and Are Coordinately Regulated by Common trans-Acting Factors

1989 • 33 citations