Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients

Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

1992 • 1,156 citations

Emerging epidemic of type 2 diabetes in youth.

1999 • 1,051 citations

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

1996 • 976 citations

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

1994 • 815 citations

Oxidative damage to DNA in diabetes mellitus

1996 • 789 citations

Dynamics of β-cell Mass in the Growing Rat Pancreas: Estimation With a Simple Mathematical Model

1995 • 607 citations

Islet Pathology and the Pathogenesis of Type 1 and Type 2 Diabetes mellitus Revisited

1985 • 580 citations

Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model.

1997 • 579 citations

Reactive oxygen species‐induced molecular damage and its application in pathology

1999 • 549 citations

Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.

1988 • 506 citations

Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release.

1983 • 466 citations

Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants

1999 • 457 citations

The pancreatic islets in diabetes

1981 • 349 citations

Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate.

1994 • 337 citations

Risk factors for worsening to diabetes in subjects with impaired glucose tolerance

1984 • 322 citations

The influence of amyloid deposits on the islet volume in maturity onset diabetes mellitus

1978 • 287 citations

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications

1995 • 269 citations

New biomarker evidence of oxidative DNA damage in patients with non‐insulin‐dependent diabetes mellitus

1997 • 263 citations

Quantitative Estimation of the Pancreatic Islet Tissue in Diabetic Subjects

1955 • 247 citations

Natural History of β-Cell Dysfunction in NIDDM

1990 • 243 citations

Histochemical detection of 4-hydroxynonenal protein in Alzheimer amyloid

1998 • 154 citations

Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus.

1995 • 150 citations

Differential volumetry of A,B and D cells in the pancreatic islets of diabetic and nondiabetic subjects.

1979 • 142 citations

Oxidative damage to mitochondrial DNA and its relationship to diabetic complications

1999 • 139 citations

Characterization of Epitopes Recognized by 4-Hydroxy-2-nonenal Specific Antibodies

1995 • 138 citations

The relation of islet amyloid to the clinical type of diabetes

1981 • 127 citations

Accelerated Loss of Islet β Cells in Sucrose-Fed Goto-Kakizaki Rats, a Genetic Model of Non-Insulin-Dependent Diabetes Mellitus

1998 • 116 citations

Decreased insulin secretion in type 2 diabetes: a problem of cellular mass or function?

2001 • 115 citations

Lipid Peroxidation and Biogenic Aldehydes: From the Identification of 4-Hydroxynonenal to Further Achievements in Biopathology

1998 • 112 citations

Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans

1982 • 75 citations

Glucose May Induce Cell Death through a Free Radical-Mediated Mechanism

1996 • 71 citations

Morphometric evidence for a striking B-cell reduction at the clinical onset of type 1 diabetes

1984 • 71 citations

Superoxide dismutase in psoriasis, squamous cell carcinoma and basal cell epithelioma: an immunohistochemical study

1991 • 68 citations

Exocrine pancreatic ductograms in insulin-dependent diabetes mellitus.

1994 • 59 citations

Pancreatic pathology in non-insulin dependent diabetes (NIDDM)

1995 • 53 citations

Poor Capacity for Proliferation of Pancreatic β-Cells in Otsuka-Long-Evans-Tokushima Fatty Rat: A Model of Spontaneous NIDDM

1996 • 51 citations

Inhibition of progressive reduction of islet β-cell mass in spontaneously diabetic Goto-Kakizaki rats by α-glucosidase inhibitor

2000 • 51 citations

Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: regulation of glutathione synthesis and efflux

1995 • 29 citations

Cu/Zn-SOD in human pancreatic tissue and pancreatic juice

1997 • 27 citations

In situ characterization of islets in diabetes with a mitochondrial DNA mutation at nucleotide position 3243

1997 • 18 citations

Islet Pathology of Non‐insulin‐dependent Diabetes Mellitus (NIDDM)

1996 • 7 citations

No decrease of the B cell mass in type 2 diabetic patients.

2000 • 6 citations