Protection of pancreatic β-cells by exendin-4 may involve the reduction of endoplasmic reticulum stress; in vivo and in vitro studies

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

2003 • 3,886 citations

Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas.

1992 • 912 citations

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

1992 • 880 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 858 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 724 citations

cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS2

2003 • 541 citations

Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca2+ ATPase 2b and Deplete Endoplasmic Reticulum Ca2+, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells

2005 • 505 citations

Glucagon-Like Peptides: Regulators of Cell Proliferation, Differentiation, and Apoptosis

2003 • 475 citations

Endoplasmic Reticulum Stress and the Development of Diabetes

2002 • 455 citations

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

2005 • 408 citations

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

1999 • 401 citations

Glucose and Tolbutamide Induce Apoptosis in Pancreatic β-Cells

1998 • 363 citations

Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice

2002 • 318 citations

Exenatide (Exendin-4) Improves Insulin Sensitivity and β-Cell Mass in Insulin-Resistant Obesefa/faZucker Rats Independent of Glycemia and Body Weight

2004 • 243 citations

Calmodulin-induced early-onset diabetes in transgenic mice

1989 • 214 citations

Exendin-4 Uses Irs2 Signaling to Mediate Pancreatic β Cell Growth and Function

2005 • 204 citations

Pancreatic Glucagon-Like Peptide-1 Receptor Couples to Multiple G Proteins and Activates Mitogen-Activated Protein Kinase Pathways in Chinese Hamster Ovary Cells*

1999 • 202 citations

The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits β-cell apoptosis in vitro

2005 • 167 citations

Apoptotic signal transduction pathways in diabetes

2003 • 151 citations

Presence and possible role of calcium-dependent regulator (calmodulin) in rat islets of langerhans

1979 • 142 citations

Isoforms of endoplasmic reticulum Ca2+-ATPase are differentially expressed in normal and diabetic islets of Langerhans

1996 • 119 citations

Glucagon-like peptide-1 (GLP-1) and glucose metabolism in human myocytes

2002 • 119 citations

Glucagon-like peptide-1(7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: one of several potential extrapancreatic sites of GLP-1 action.

1994 • 114 citations

Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors

1997 • 107 citations

Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus

2005 • 96 citations

Insulin-independent effects of GLP-1 on canine liver glucose metabolism: duration of infusion and involvement of hepatoportal region

2004 • 90 citations

Islet Secretory Defect in Insulin Receptor Substrate 1 Null Mice Is Linked With Reduced Calcium Signaling and Expression of Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA)-2b and -3

2004 • 89 citations

Sequence variants of the sarco(endo)plasmic reticulum Ca 2+ -transport ATPase 3 gene (SERCA3) in Caucasian Type II diabetic patients (UK Prospective Diabetes Study 48)

1999 • 85 citations

Amplification of exocytosis by Ca²⁺‐induced Ca²⁺ release in INS‐1 pancreatic β cells

2003 • 75 citations

Pancreatic Glucagon-Like Peptide-1 Receptor Couples to Multiple G Proteins and Activates Mitogen-Activated Protein Kinase Pathways in Chinese Hamster Ovary Cells

1999 • 51 citations

Glucagon-like peptide-1(7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: one of several potential extrapancreatic sites of GLP-1 action

1994 • 38 citations

[Ca²⁺]_i-reducing action of cAMP in rat pancreatic β-cells: involvement of thapsigargin-sensitive stores

1998 • 33 citations

Cyclic AMP alleviates endoplasmic stress and programmed cell death induced by lipopolysaccharides in human endothelial cells

2005 • 33 citations

Calmodulin Overexpression Causes Ca2+-Dependent Apoptosis of Pancreatic β Cells, Which Can Be Prevented by Inhibition of Nitric Oxide Synthase

2002 • 28 citations

Calmodulin and pancreatic B-cell function

1984 • 21 citations

Systemic administration of pituitary adenylate cyclase-activating polypeptide maintains beta-cell mass and retards onset of hyperglycaemia in beta-cell-specific calmodulin-overexpressing transgenic mice

2005 • 10 citations