A cytokine-mediated link between innate immunity, inflammation, and cancer

The Hallmarks of Cancer

2000 • 27,569 citations

Inflammation and cancer

2002 • 14,174 citations

Pathogen Recognition and Innate Immunity

2006 • 11,197 citations

Inflammation and cancer: back to Virchow?

2001 • 7,259 citations

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

2002 • 5,109 citations

Smad-dependent and Smad-independent pathways in TGF-β family signalling

2003 • 5,052 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

Toll-like receptors and innate immunity

2001 • 4,138 citations

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

2005 • 3,961 citations

Interleukin-12 and the regulation of innate resistance and adaptive immunity

2003 • 3,689 citations

Nuclear factor-κB in cancer development and progression

2006 • 3,334 citations

Inflammatory Bowel Disease

2002 • 3,038 citations

Transforming growth factor-β induces development of the TH17 lineage

2006 • 3,014 citations

NF-κB: linking inflammation and immunity to cancer development and progression

2005 • 2,878 citations

NF-κB in cancer: from innocent bystander to major culprit

2002 • 2,457 citations

NF-κB functions as a tumour promoter in inflammation-associated cancer

2004 • 2,370 citations

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

2004 • 2,361 citations

Hepatogastroenterology

2012 • 2,302 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

Paradoxical roles of the immune system during cancer development

2006 • 2,213 citations

Smoldering and polarized inflammation in the initiation and promotion of malignant disease

2005 • 1,730 citations

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

2003 • 1,652 citations

Radical causes of cancer

2003 • 1,611 citations

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

1998 • 1,451 citations

Immune cell migration in inflammation: present and future therapeutic targets

2005 • 1,262 citations

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

1996 • 1,128 citations

Cytokine Signaling in 2002

2002 • 1,089 citations

I<scp>nterleukin</scp>-10<scp>and</scp>R<scp>elated</scp>C<scp>ytokines and</scp>R<scp>eceptors</scp>

2004 • 1,063 citations

IL-23 promotes tumour incidence and growth

2006 • 968 citations

The role of IL-6 and STAT3 in inflammation and cancer

2005 • 923 citations

Interleukin-17 family and IL-17 receptors

2003 • 905 citations

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1999 • 890 citations

Nod-like proteins in immunity, inflammation and disease

2006 • 866 citations

Apo2L/TRAIL and its death and decoy receptors

2003 • 851 citations

IKK/NF- B signaling: balancing life and death - a new approach to cancer therapy

2005 • 838 citations

Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis

1999 • 833 citations

Interleukin-17 promotes angiogenesis and tumor growth

2002 • 795 citations

IL-6 in autoimmune disease and chronic inflammatory proliferative disease

2002 • 793 citations

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signalsin vivo

2004 • 761 citations

CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

2003 • 748 citations

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

1995 • 743 citations

Inflammation, atrophy, and gastric cancer

2007 • 737 citations

Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation

2005 • 716 citations

TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling

2004 • 706 citations

Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

2006 • 634 citations

Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression

2004 • 598 citations

Chronic Inflammation and Cancer

2013 • 585 citations

Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B

1996 • 582 citations

The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions

2006 • 558 citations

Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy

2003 • 552 citations

Signaling by IL‐12 and IL‐23 and the immunoregulatory roles of STAT4

2004 • 547 citations

The TREM receptor family and signal integration

2006 • 531 citations

Interleukin-10 Signaling Blocks Inhibitor of κB Kinase Activity and Nuclear Factor κB DNA Binding

1999 • 517 citations

Myeloid C-type lectins in innate immunity

2006 • 505 citations

Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development

2002 • 447 citations

Tumor-Driven Evolution of Immunosuppressive Networks during Malignant Progression

2006 • 443 citations

Tumor-induced immune dysfunction: the macrophage connection

1998 • 433 citations

Mechanisms of Disease: insights into the emerging role of signal transducers and activators of transcription in cancer

2005 • 425 citations

Interleukin-1 and cancer progression: the emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment

2006 • 425 citations

IL-17 Enhances the Net Angiogenic Activity and In Vivo Growth of Human Non-Small Cell Lung Cancer in SCID Mice through Promoting CXCR-2-Dependent Angiogenesis

2005 • 404 citations

Cytokines in cancer immunity and immunotherapy

2004 • 398 citations

Interleukin-10 and the immune response against cancer: a counterpoint

2005 • 393 citations

Interleukin-17 inhibits tumor cell growth by means of a T-cell–dependent mechanism

2002 • 348 citations

Functional Cooperation between Interleukin-17 and Tumor Necrosis Factor-α Is Mediated by CCAAT/Enhancer-binding Protein Family Members

2004 • 344 citations

Inflammation-associated immune suppression in cancer: The roles played by cytokines, chemokines and additional mediators

2005 • 324 citations

STAT3 and NF-κB Signal Pathway Is Required for IL-23-Mediated IL-17 Production in Spontaneous Arthritis Animal Model IL-1 Receptor Antagonist-Deficient Mice

2006 • 308 citations

Tumor necrosis factor, cancer and anticancer therapy

2004 • 305 citations

Limiting inflammatory responses during activation of innate immunity

2005 • 304 citations

CD4+ CD25+ Regulatory T Lymphocytes Inhibit Microbially Induced Colon Cancer in Rag2-Deficient Mice

2003 • 300 citations

TNF-α inhibits asbestos-induced cytotoxicity via a NF-κB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis

2006 • 295 citations

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling

2005 • 294 citations

Impaired Preneoplastic Changes and Liver Tumor Formation in Tumor Necrosis Factor Receptor Type 1 Knockout Mice

2000 • 294 citations

Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice.

1999 • 291 citations

Inhibition of interleukin 10 by rituximab results in down-regulation of bcl-2 and sensitization of B-cell non-Hodgkin's lymphoma to apoptosis.

2001 • 287 citations

NF‐κB and cancer: Mechanisms and targets

2006 • 286 citations

IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice.

1998 • 256 citations

Interleukin-17: a mediator of inflammatory responses

2004 • 252 citations

Lipopolysaccharide‐induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion

2002 • 249 citations

Tumor-derived CD4+CD25+ regulatory T cell suppression of dendritic cell function involves TGF-β and IL-10

2006 • 223 citations

TGF-β: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression

2003 • 207 citations

Expression of both TNF-α receptor subtypes is essential for optimal skin tumour development

2003 • 206 citations

CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice.

2003 • 206 citations

Helicobacter Infection Is Required for Inflammation and Colon Cancer in Smad3-Deficient Mice

2006 • 204 citations

CD4+CD25+ Regulatory Lymphocytes Induce Regression of Intestinal Tumors in ApcMin/+ Mice

2005 • 203 citations

IL-12, But Not IFN-γ, Plays a Major Role in Sustaining the Chronic Phase of Colitis in IL-10-Deficient Mice

1998 • 201 citations

Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice.

2002 • 195 citations

Molecular mechanisms of inactivation of TGF-β receptors during carcinogenesis

2000 • 186 citations

The role of tumor stroma in the interaction between tumor and immune system

2005 • 179 citations

Antitumor and Antimetastatic Activity of IL-23

2003 • 174 citations

NOD2 and Crohn’s Disease: Loss or Gain of Function?

2005 • 174 citations

Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors

2006 • 166 citations

Regulation of Tumor Growth and Metastasis by Interleukin-10: The Melanoma Experience

1999 • 161 citations

Signalling and survival pathways in multiple myeloma

2006 • 159 citations

T cells require TRAIL for optimal graft-versus-tumor activity

2002 • 151 citations

IMPLICATION OF TOLL-LIKE RECEPTOR AND TUMOR NECROSIS FACTOR α SIGNALING IN SEPTIC SHOCK

2005 • 150 citations

Toll-like receptors mediate proliferation and survival of multiple myeloma cells

2006 • 148 citations

STAT3 regulates NF-κB recruitment to the IL-12p40 promoter in dendritic cells

2004 • 146 citations

Enhanced Apoptotic Cell Clearance Capacity and B Cell Survival Factor Production by IL-10-Activated Macrophages: Implications for Burkitt’s Lymphoma

2005 • 145 citations

The role of endotoxin/lipopolysaccharide in surgically induced tumour growth in a murine model of metastatic disease

1999 • 145 citations

Interleukin-10 Inhibits Tumor Metastasis, Downregulates MHC Class I, and Enhances NK Lysis

1997 • 138 citations

KSHV-encoded viral IL-6 activates multiple human IL-6 signaling pathways

1999 • 135 citations

Immunodeficiency and cancer: prospects for correction

2003 • 135 citations

IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma

2004 • 127 citations

Essential roles of tumor necrosis factor receptor p55 in liver metastasis of intrasplenic administration of colon 26 cells.

2002 • 116 citations

Interleukin‐10 in viral diseases and cancer: exiting the labyrinth?

2004 • 114 citations

The p53 Tumor Suppressor Network Is a Key Responder to Microenvironmental Components of Chronic Inflammatory Stress

2005 • 99 citations

Inflammation and Cancer: When NF-&amp;#954;B Amalgamates the Perilous Partnership

2005 • 96 citations

TGF-beta as a T cell regulator in colitis and colon cancer

2005 • 95 citations

Ammonium Trichloro(dioxoethylene-o,o′)tellurate (AS101) Sensitizes Tumors to Chemotherapy by Inhibiting the Tumor Interleukin 10 Autocrine Loop

2004 • 94 citations

Interleukin-10-mediated inhibition of angiogenesis and tumor growth in mice bearing VEGF-producing ovarian cancer.

2003 • 91 citations

Interleukin‐10 promotes B16‐melanoma growth by inhibition of macrophage functions and induction of tumour and vascular cell proliferation

2002 • 87 citations

Elevated IL-10 plasma levels correlate with poor prognosis in diffuse large B-cell lymphoma.

2006 • 83 citations

Cutting Edge: IL-10-Producing CD4+ T Cells Mediate Tumor Rejection

2002 • 80 citations

Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and -independent antitumor effects

2003 • 74 citations

Receptor synergy of interleukin-6 (IL-6) and insulin-like growth factor-I in myeloma cells that highly express IL-6 receptor α

2003 • 69 citations

The interleukin-6 gene: a susceptibility factor that may contribute to racial and ethnic disparities in breast cancer mortality

2004 • 68 citations

Mouse plasmacytoma: an experimental model of human multiple myeloma.

2001 • 62 citations

Interactions of Sequence Variants inInterleukin-1 Receptor–Associated Kinase4and theToll-Like Receptor 6-1-10Gene Cluster Increase Prostate Cancer Risk

2006 • 60 citations

Immune enhancement and anti-tumour activity of IL-23

2006 • 53 citations

Studies in NZB IL-10 knockout mice of the requirement of IL-10 for progression of B-cell lymphoma

2004 • 53 citations

Polymorphism of IL-1 receptor antagonist gene: role in cancer.

2003 • 44 citations

The Role of Interleukin-1Beta and Other Potential Genetic Markers as Indicators of Gastric Cancer Risk

2003 • 31 citations

Circulating intercellular adhesion molecule-1 in patients with hepatocellular carcinoma before and after hepatic resection.

1997 • 25 citations

The rational designed antagonist derived from the complex structure of interleukin-6 and its receptor affectively blocking interleukin-6 might be a promising treatment in multiple myeloma

2006 • 7 citations