I<scp>nterleukin</scp>-10<scp>and</scp>R<scp>elated</scp>C<scp>ytokines and</scp>R<scp>eceptors</scp>

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STATs and Gene Regulation

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Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

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Stat3 as an Oncogene

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Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

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2002 • 1,790 citations

IL-28, IL-29 and their class II cytokine receptor IL-28R

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Clinical translation of angiogenesis inhibitors

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Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

1990 • 1,155 citations

THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling

1997 • 1,001 citations

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

1996 • 920 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

Characterization of Dendritic Cells that Induce Tolerance and T Regulatory 1 Cell Differentiation In Vivo

2003 • 811 citations

IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

2001 • 799 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

1999 • 767 citations

3D domain swapping: A mechanism for oligomer assembly

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The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

1996 • 726 citations

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

1999 • 712 citations

Interleukin (IL)-10 Inhibits Nuclear Factor кB (NFкB) Activation in Human Monocytes

1995 • 698 citations

The human interferon $alpha;/$beta; receptor: Characterization and molecular cloning

1994 • 658 citations

Erythropoietin Receptor Activation by a Ligand-Induced Conformation Change

1999 • 624 citations

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

1999 • 620 citations

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

1998 • 596 citations

Genetic transfer of a functional human interferon α receptor into mouse cells: Cloning and expression of its c-DNA

1990 • 582 citations

Cutting Edge: Immune Cells as Sources and Targets of the IL-10 Family Members?

2002 • 580 citations

Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice.

1994 • 543 citations

Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus.

1995 • 542 citations

Interleukin 20

2001 • 542 citations

Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1

1990 • 539 citations

Interleukin (IL)-22, a Novel Human Cytokine That Signals through the Interferon Receptor-related Proteins CRF2–4 and IL-22R

2000 • 531 citations

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

1992 • 530 citations

Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance.

1993 • 526 citations

Interleukin-10 Signaling Blocks Inhibitor of κB Kinase Activity and Nuclear Factor κB DNA Binding

1999 • 517 citations

Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)

2000 • 504 citations

Cloning and Characterization of IL-10-Related T Cell-Derived Inducible Factor (IL-TIF), a Novel Cytokine Structurally Related to IL-10 and Inducible by IL-9

2000 • 497 citations

Molecular cloning and expression of the human interferon-γ receptor

1988 • 481 citations

Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression.

1995 • 479 citations

Clinical and biologic effects of anti-interleukin-10 monoclonal antibody administration in systemic lupus erythematosus

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Three-dimensional structure of a genetically engineered variant of porcine growth hormone.

1987 • 457 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

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Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease

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Three-dimensional structure of recombinant human interferon-gamma

1991 • 420 citations

IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes.

1995 • 420 citations

IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes

1999 • 409 citations

Interleukin‐10 inhibits B7 and intercellular adhesion molecule‐1 expression on human monocytes

1994 • 396 citations

Cutting Edge: STAT Activation By IL-19, IL-20 and mda-7 Through IL-20 Receptor Complexes of Two Types

2001 • 394 citations

Identification of the Functional Interleukin-22 (IL-22) Receptor Complex

2001 • 390 citations

Interleukin-10 Receptor Signaling through the JAK-STAT Pathway

1999 • 384 citations

Identification and functional characterization of a second chain of the interleukin-10 receptor complex

1997 • 376 citations

IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function.

1992 • 375 citations

The alliance of genes and environment in asthma and allergy

1999 • 370 citations

Testosterone Acts Directly on CD4+ T Lymphocytes to Increase IL-10 Production

2001 • 368 citations

Vaccinia Virus B18R Gene Encodes a Type I Interferon-binding Protein That Blocks Interferon α Transmembrane Signaling

1995 • 367 citations

Human interleukin-10-related T cell-derived inducible factor: Molecular cloning and functional characterization as an hepatocyte-stimulating factor

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Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor

1995 • 350 citations

Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10

1990 • 347 citations

Regulation of neutrophil-derived chemokine expression by IL-10.

1994 • 347 citations

Biologic consequences of Stat1-independent IFN signaling

2001 • 345 citations

Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein.

1994 • 344 citations

Co-evolution of ligand-receptor pairs

1994 • 340 citations

Activation of STAT3 by IL-6 and IL-10 in Primary Human Macrophages Is Differentially Modulated by Suppressor of Cytokine Signaling 3

2003 • 333 citations

Expression cloning and characterization of a human IL-10 receptor.

1994 • 327 citations

Interleukin-10 Is a Natural Suppressor of Cytokine Production and Inflammation in a Murine Model of Allergic Bronchopulmonary Aspergillosis

1997 • 324 citations

IL-19 Induces Production of IL-6 and TNF-α and Results in Cell Apoptosis Through TNF-α

2002 • 317 citations

Regulation of c-myc expression by IFN-γ through Stat1-dependent and -independent pathways

2000 • 314 citations

Evolution of Two-Component Signal Transduction

2000 • 310 citations

mda- 7 (IL-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK

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Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines.

1994 • 299 citations

Specific molecular activities of recombinant and hybrid leukocyte interferons.

1982 • 298 citations

Molecular and Functional Analysis of an Interferon Gene from the Zebrafish, Danio rerio

2003 • 294 citations

Cloning, expression and initial characterisation of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10)

2000 • 285 citations

Testosterone therapy ameliorates experimental autoimmune encephalomyelitis and induces a T helper 2 bias in the autoantigen-specific T lymphocyte response.

1997 • 282 citations

The melanoma differentiation associated gene mda-7 suppresses cancer cell growth.

1996 • 277 citations

Phenotypic characterization of human decidual macrophages

2003 • 277 citations

Hormones, Pregnancy, and Autoimmune Diseases

1998 • 269 citations

Interferon-κ, a Novel Type I Interferon Expressed in Human Keratinocytes

2001 • 268 citations

Identification and sequence of an accessory factor required for activation of the human interferon γ receptor

1994 • 266 citations

The Protein Product of the Tumor Suppressor Gene, Melanoma Differentiation-Associated Gene 7, Exhibits Immunostimulatory Activity and Is Designated IL-24

2002 • 262 citations

Interleukins 19, 20, and 24 Signal through Two Distinct Receptor Complexes

2002 • 260 citations

Interleukin 24 (MDA-7/MOB-5) Signals through Two Heterodimeric Receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2

2002 • 259 citations

Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon gamma

2002 • 253 citations

Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production.

1993 • 251 citations

Cloning and Characterization of IL-22 Binding Protein, a Natural Antagonist of IL-10-Related T Cell-Derived Inducible Factor/IL-22

2001 • 248 citations

Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.

1995 • 247 citations

Stat1-independent regulation of gene expression in response to IFN-γ

2001 • 243 citations

Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses.

1995 • 243 citations

Elevated interleukin-10 levels correlated with disease activity in systemic lupus erythematosus.

1998 • 243 citations

Cloning and Expression of a Long Form of the β Subunit of the Interferon αβ Receptor That Is Required for Signaling

1995 • 241 citations

Interleukin 10 Increases CCR5 Expression and HIV Infection in Human Monocytes

1998 • 238 citations

Comparative genomic analysis reveals independent expansion of a lineage-specific gene family in vertebrates: The class II cytokine receptors and their ligands in mammals and fish

2003 • 237 citations

The human interferons—From protein purification and sequence to cloning and expression in bacteria: Before, between, and beyond

1983 • 236 citations

A receptor for interleukin 10 is related to interferon receptors.

1993 • 233 citations

Human leukocyte interferon: production, purification to homogeneity, and initial characterization.

1979 • 233 citations

Linkage of Asthma and Total Serum IgE Concentration to Markers on Chromosome 12q: Evidence from Afro-Caribbean and Caucasian Populations

1996 • 226 citations

Zinc mediated dimer of human interferon-α2b revealed by X-ray crystallography

1996 • 223 citations

Characterization of the type I interferon locus and identification of novel genes☆

2004 • 221 citations

Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon γ

1995 • 219 citations

Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties

2001 • 218 citations

Crystal structure of the extracellular region of human tissue factor

1994 • 218 citations

Enhanced expression of surface tumor-associated antigens on human breast and colon tumor cells after recombinant human leukocyte alpha-interferon treatment.

1984 • 217 citations

Crystal Structure of the Interleukin-4/Receptor α Chain Complex Reveals a Mosaic Binding Interface

1999 • 216 citations

An antagonist peptide–EPO receptor complex suggests that receptor dimerization is not sufficient for activation

1998 • 216 citations

The family of IL-10-related cytokines and their receptors: related, but to what extent?

2002 • 213 citations

Stat3 Recruitment by Two Distinct Ligand-induced, Tyrosine-phosphorylated Docking Sites in the Interleukin-10 Receptor Intracellular Domain

1996 • 211 citations

Induction of a Novel Cellular Homolog of Interleukin-10, AK155, by Transformation of T Lymphocytes with Herpesvirus Saimiri

2000 • 210 citations

A homolog of interleukin-10 is encoded by the poxvirus orf virus

1997 • 210 citations

A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist

2001 • 210 citations

Expression of Intracellular Th1 and Th2 Cytokines in Women with Recurrent Spontaneous Abortion, Implantation Failures after IVF/ET or Normal Pregnancy

2002 • 207 citations

A novel member of the interferon receptor family complements functionality of the murine interferon γ receptor in human cells

1994 • 205 citations

The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells

2002 • 204 citations

Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes

2000 • 201 citations

The crystal structure of human interferon β at 2.2-Å resolution

1997 • 201 citations

Crystal Structure of the IL-10/IL-10R1 Complex Reveals a Shared Receptor Binding Site

2001 • 199 citations

Continuous anti-interleukin 10 antibody administration depletes mice of Ly-1 B cells but not conventional B cells.

1992 • 197 citations

Structural relationship of human interferon alpha genes and pseudogenes

1985 • 195 citations

Biology of the interferon system

1983 • 192 citations

The interferon receptors.

1997 • 191 citations

IL-10 enhances NK cell proliferation, cytotoxicity and production of IFN-γ when combined with IL-18

1999 • 190 citations

IL-10 Gene Knockout Mice Show Enhanced Th1-Like Protective Immunity and Absent Granuloma Formation FollowingChlamydia trachomatisLung Infection

1999 • 189 citations

Increased Antimycobacterial Immunity in Interleukin-10-Deficient Mice

1999 • 188 citations

Interleukin-9 Promotes Allergen-Induced Eosinophilic Inflammation and Airway Hyperresponsiveness in Transgenic Mice

1998 • 186 citations

SOCS-1/SSI-1-Deficient NKT Cells Participate in Severe Hepatitis through Dysregulated Cross-Talk Inhibition of IFN-γ and IL-4 Signaling In Vivo

2001 • 185 citations

Human IL-10 is a chemoattractant for CD8+ T lymphocytes and an inhibitor of IL-8-induced CD4+ T lymphocyte migration.

1993 • 184 citations

Recombinant Interferon Enhances Monoclonal Antibody-Targeting of Carcinoma Lesions in Vivo

1987 • 178 citations

IL‐10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes

1996 • 170 citations

The interferon gamma (IFN-γ) receptor: a paradigm for the multichain cytokine receptor

1997 • 169 citations

Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner

2003 • 167 citations

Melanoma Differentiation Associated Gene-7 (mda-7): A Novel Anti-Tumor Gene for Cancer Gene Therapy

2001 • 164 citations

The three-dimensional high resolution structure of human interferon α-2a determined by heteronuclear NMR spectroscopy in solution

1997 • 163 citations

Primate Cytomegaloviruses Encode and Express an IL-10-like Protein

2000 • 162 citations

Interleukin 10 induces apoptotic cell death of B-chronic lymphocytic leukemia cells.

1994 • 162 citations

Seeing the Light

2002 • 159 citations

Dominant IL‐10 and TGF‐β mRNA Expression in γδT Cells of Human Early Pregnancy Decidua Suggests Immunoregulatory Potential

2002 • 158 citations

A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells

2001 • 155 citations

IL-10-Deficient Mice Demonstrate Multiple Organ Failure and Increased Mortality During Escherichia coli Peritonitis Despite an Accelerated Bacterial Clearance

2001 • 154 citations

Effect of human recombinant interferon on cytotoxic activity of natural killer (NK) cells and monocytes

1982 • 152 citations

Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo

2002 • 152 citations

MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine

2002 • 152 citations

Interleukin‐10 inhibits the primary allogeneic T cell response to human epidermal Langerhans cells

1994 • 151 citations

Ligand-Induced Assembly and Activation of the Gamma Interferon Receptor in Intact Cells

1996 • 149 citations

New Structural and Functional Aspects of the Type I Interferon-Receptor Interaction Revealed by Comprehensive Mutational Analysis of the Binding Interface

2000 • 146 citations

Structure of the Extracellular Domain of Human Tissue Factor: Location of the Factor VIIa Binding Site

1994 • 143 citations

Interleukin‐10 rescues T cells from apoptotic cell death: association with an upregulation of Bcl‐2

1997 • 141 citations

Characterisation, expression and promoter analysis of an interleukin 10 homologue in the puffer fish, Fugu rubripes

2003 • 141 citations

The MUC gene family: their role in diagnosis and early detection of pancreatic cancer.

2003 • 138 citations

Suppressor of Cytokine Signaling 1 Inhibits IL-10-Mediated Immune Responses

2003 • 134 citations

The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat‐shock protein 60 capable of producing the regulatory cytokine interleukin‐10

2003 • 133 citations

Crystal Structure of Interleukin 10 Reveals an Interferon .gamma.-like Fold

1995 • 132 citations

Human leukocyte interferon: Isolation and characterization of several molecular forms

1981 • 132 citations

Endogenous interleukin‐10 suppresses allergen‐induced airway inflammation and nonspecific airway responsiveness

2000 • 132 citations

The human interferon ? species and receptors

2000 • 131 citations

Mammalian and Viral IL-10 Enhance C-C Chemokine Receptor 5 but Down-Regulate C-C Chemokine Receptor 7 Expression by Myeloid Dendritic Cells: Impact on Chemotactic Responses and In Vivo Homing Ability

2001 • 130 citations

Construction and identification of bacterial plasmids containing nucleotide sequence for human leukocyte interferon.

1980 • 128 citations

Loss of MDA-7 Expression With Progression of Melanoma

2002 • 128 citations

Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1

2002 • 128 citations

Crystal Structure of Recombinant Human Interleukin-22

2002 • 127 citations

Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3

2003 • 126 citations

Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors

2000 • 125 citations

Bcl-2 and Bcl-xL differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24

2003 • 124 citations

Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR).

2002 • 124 citations

Complete Nucleotide Sequence of the Rhesus Lymphocryptovirus: Genetic Validation for an Epstein-Barr Virus Animal Model

2002 • 123 citations

Interleukin-10-mediated inhibition of free radical generation in macrophages

2001 • 121 citations

Down-regulated melanoma differentiation associated gene (mda-7) expression in human melanomas

2001 • 121 citations

Interferon inhibits the conversion of 3T3-L1 mouse fibroblasts into adipocytes.

1980 • 121 citations

Effects of several species of human leukocyte interferon on cytotoxic activity of NK cells and monocytes

1983 • 117 citations

A species of human alpha interferon that lacks the ability to boost human natural killer activity.

1984 • 117 citations

Interferon increases HLA synthesis in melanoma cells: interferon-resistant and -sensitive cell lines.

1982 • 115 citations

IL-9 pathway in asthma: New therapeutic targets for allergic inflammatory disorders

1999 • 115 citations

Evidence for Linkage of Chromosome 12q15–q24.1 Markers to High Total Serum IgE Concentrations in Children of the German Multicenter Allergy Study

1997 • 113 citations

The soluble murine type I interferon receptor Ifnar-2 is present in serum, is independently regulated, and has both agonistic and antagonistic properties

2001 • 106 citations

Effects of Combined Treatment with Interferon and Mezerein on Melanogenesis and Growth in Human Melanoma Cells

1985 • 105 citations

Human Leukocyte Interferon Purified to Homogeneity

1978 • 105 citations

The Crystal Structure of the Extracellular Domain of Human Tissue Factor Refined to 1.7 Å Resolution

1996 • 104 citations

Comparison of Interleukin-22 and Interleukin-10 Soluble Receptor Complexes

2002 • 101 citations

The structure of the human interferon alpha/beta receptor gene.

1992 • 100 citations

Observation of an unexpected third receptor molecule in the crystal structure of human interferon-γ receptor complex

2000 • 99 citations

Complete Genomic Sequence of an Epstein-Barr Virus-Related Herpesvirus Naturally Infecting a New World Primate: a Defining Point in the Evolution of Oncogenic Lymphocryptoviruses

2002 • 98 citations

Interferon-delta: The first member of a novel type I interferon family

1998 • 97 citations

Antiproliferative and antiviral activities of human leukocyte interferons

1981 • 97 citations

Comparative Genomic Analysis of the Interferon/Interleukin-10 Receptor Gene Cluster

1999 • 95 citations

Up-Regulation of IL-10R1 Expression Is Required to Render Human Neutrophils Fully Responsive to IL-10

2001 • 95 citations

Early Resistance of Interleukin-10 Knockout Mice to Acute Systemic Candidiasis

1999 • 93 citations

Mda‐7/IL‐24 induces apoptosis of diverse cancer cell lines through JAK/STAT‐independent pathways

2003 • 93 citations

The genome of equine herpesvirus type 2 harbors an interleukin 10 (IL10)-like gene

1993 • 93 citations

Mutational and structural analysis of the binding interface between type I interferons and their receptor ifnar2 1 1Edited by J. A. Wells

1999 • 92 citations

Origin and Evolution of Viral Interleukin-10 and Other DNA Virus Genes with Vertebrate Homologues

2002 • 91 citations

Interferons and Apoptosis

2003 • 91 citations

Other Kinases Can Substitute for Jak2 in Signal Transduction by Interferon-γ

1996 • 90 citations

Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant 1 1Edited by R. Huber

1999 • 89 citations

Mda-7, A Novel Melanoma Differentiation Associated Gene with Promise for Cancer Gene Therapy

2002 • 88 citations

Differential IL-10R1 Expression Plays a Critical Role in IL-10-Mediated Immune Regulation

2001 • 87 citations

A New Member of the Cytokine Receptor Gene Family Maps on Chromosome 21 at Less Than 35 kb from IFNAR

1993 • 86 citations

The human interferon-alpha species and hybrid proteins.

1997 • 86 citations

Crystal Structure of Interleukin-19 Defines a New Subfamily of Helical Cytokines

2003 • 85 citations

Human Interferon-γ Enhances the Expression of Class I and Class II Major Histocompatibility Complex Products in Neoplastic Cells More Effectively than Interferon-α and Interferon-β

1983 • 84 citations

Cutting Edge: FISP (IL-4-Induced Secreted Protein), a Novel Cytokine-Like Molecule Secreted by Th2 Cells

2001 • 82 citations

Dense mapping of chromosome 12q13.12-q23.3 and linkage to asthma and atopy

1999 • 81 citations

The Human Type I Interferon Receptor

2003 • 81 citations

Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible docking

2001 • 81 citations

Cutaneous rat wounds expressC49a, a novel gene with homology to the human melanoma differentiation associated gene,Mda-7

1999 • 79 citations

Crystal structure of epstein-barr virus protein BCRF1, a homolog of cellular interleukin-10 1 1Edited by R. Huber

1997 • 79 citations

Soluble interferon‐α receptor molecules are present in body fluids

1992 • 79 citations

Effects of recombinant and hybrid recombinant human leukocyte interferons on cytotoxic activity of natural killer cells.

1983 • 76 citations

Antigen-specific activation, tolerization, and reactivation of the interleukin 4 pathway in vivo.

1994 • 74 citations

A Mutant Form of JAB/SOCS1 Augments the Cytokine-induced JAK/STAT Pathway by Accelerating Degradation of Wild-type JAB/CIS Family Proteins through the SOCS-box

2001 • 73 citations

mda-7 (IL-24): Signaling and Functional Roles

2002 • 73 citations

Systematic Mutational Mapping of Sites on Human Interferon-β-1a That Are Important for Receptor Binding and Functional Activity

2000 • 73 citations

Gender Differences in the Allergic Response of Mice Neonatally Exposed to Environmental Tobacco Smoke

2002 • 71 citations

[1] Interferon from 1981 to 1986

1986 • 69 citations

Tissue factor signal transduction in angiogenesis

2003 • 67 citations

Clinical and Immunologic Assessment of Patients With Psoriasis in a Randomized, Double-blind, Placebo-Controlled Trial Using Recombinant Human Interleukin 10

2002 • 67 citations

Cloning and characterization of mouse IL-22 binding protein

2003 • 67 citations

Differential Expression of Viral and Human Interleukin-10 (IL-10) by Primary B Cell Tumors and B Cell Lines

1994 • 66 citations

A novel, soluble homologue of the human IL-10 receptor with preferential expression in placenta

2001 • 64 citations

Differential Responsiveness of a Splice Variant of the Human Type I Interferon Receptor to Interferons

1996 • 61 citations

Sequence and Functional Analysis of a Homolog of Interleukin-10 Encoded by the Parapoxvirus Orf Virus

2000 • 60 citations

INTERLEUKIN-10 STABILIZES INHIBITORY kB-α IN HUMAN MONOCYTES

1998 • 58 citations

Increased Interleukin-10 mRNA Stability in Melanoma Cells Is Associated with Decreased Levels of A + U-Rich Element Binding Factor AUF1

2003 • 58 citations

NH2-terminal amino acid sequence of human fibroblast interferon.

1980 • 57 citations

Identification of a Novel Ligand-Receptor Pair Constitutively Activated by ras Oncogenes

2000 • 57 citations

Contribution of the Box 1 and Box 2 Motifs of Cytokine Receptors to Jak1 Association and Activation

2002 • 56 citations

Regulation of Neoplastic Angiogenesis

2000 • 56 citations

Regulation of mda-7 gene expression during human melanoma differentiation

2000 • 54 citations

Structural and Biological Stability of the Human Interleukin 10 Homodimer

1998 • 54 citations

The Short Form of the Interferon α/β Receptor Chain 2 Acts as a Dominant Negative for Type I Interferon Action

1997 • 51 citations

Design and Analysis of an Engineered Human Interleukin-10 Monomer

2000 • 50 citations

Expression of Interleukin-10 and Its Receptor Is Up-Regulated in Early PregnantVersusCycling Human Endometrium

2002 • 49 citations

Negative association of melanoma differentiation-associated gene (mda-7) and inducible nitric oxide synthase (iNOS) in human melanoma: MDA-7 regulates iNOS expression in melanoma cells.

2003 • 48 citations

AP-1 and C/EBP transcription factors contribute tomda-7 gene promoter activity during human melanoma differentiation

2000 • 47 citations

Preeclampsia is Associated with a Reduced Interleukin‐10 Production from Peripheral Blood Mononuclear Cells

2003 • 45 citations

Crystal structure of ovine interferon-τ at 2.1 Å resolution

1999 • 45 citations

Refined Crystal Structure of Recombinant Murine Interferon-β at 2.15 Å Resolution

1995 • 44 citations

The intracellular domain of interferon-α receptor 2c (IFN-αR2c) chain is responsible for Stat activation

1999 • 43 citations

IL-24 is Expressed by Rat and Human Macrophages

2002 • 43 citations

The Structure and Activity of a Monomeric Interferon-γ:α-Chain Receptor Signaling Complex

2001 • 42 citations

Mutation screening of interferon‐gamma (IFNγ) as a candidate gene for asthma

1997 • 39 citations

A comparison of the anti-inflammatory and immuno-stimulatory activities of orf virus and ovine interleukin-10

2002 • 38 citations

The Human Interferon Receptor: NMR-Based Modeling, Mapping of the IFN-α2 Binding Site, and Observed Ligand-Induced Tightening^,

2002 • 37 citations

Unique features of the trophoblast interferons

1991 • 37 citations

Modulation of tumor associated antigen expression and shedding by recombinant human leukocyte and fibroblast interferons

1985 • 34 citations

Two Distinct Domains Within the N-Terminal Region of Janus Kinase 1 Interact with Cytokine Receptors

2002 • 32 citations

Inhibition of tumor rejection by γδ T cells and IL-10

2003 • 32 citations

Identification of Critical Residues in Bovine IFNAR-1 Responsible for Interferon Binding

2001 • 32 citations

Design, characterization, and structure of a biologically active single-chain mutant of human IFN-γ 1 1Edited by I. A. Wilson

2000 • 30 citations

Novel polymorphisms in the IL-10 related AK155 gene (chromosome 12q15)

2001 • 30 citations

Unusually large interferon-α-like mRNAs and high expression of interleukin-6 in human fetal annexes

1989 • 29 citations

Identification of mRNAs encoding two different soluble forms of the human interferon α‐receptor

1994 • 28 citations

Noncompetitive Antibody Neutralization of IL-10 Revealed by Protein Engineering and X-Ray Crystallography

2002 • 28 citations

IL-20: a new target for the treatment of inflammatory skin disease

2003 • 25 citations

Signaling by Covalent Heterodimers of Interferon-γ

2000 • 25 citations

Valence bond and molecular orbital studies of three N2O isomers, and valence bond representations for some azide decompositions

2001 • 24 citations

Characterization of the antiviral activity constitutively produced by murine conceptuses: Absence of placental mrnas for interferon alpha and beta

1990 • 24 citations

The 2.0 Å structure of bovine interferon-γ; assessment of the structural differences between species

2000 • 19 citations

Hybrid recombinant human leukocyte interferon inhibits differentiation in murine B-16 melanoma cells

1984 • 18 citations

Transcriptional analysis of the Epstein--Barr virus interleukin-10 homologue during the lytic cycle

1996 • 18 citations

Hinge bending within the cytokine receptor superfamily revealed by the 2.4 Å crystal structure of the extracellular domain of rabbit tissue factor

1998 • 18 citations

A novel IL-10 signalling mechanism regulates TIMP-1 expression in human prostate tumour cells

2003 • 17 citations

Structure of the human CRFB4 gene: Comparison with its IFNAR neighbor

1995 • 16 citations

Candidate Gene and Mutational Analysis in Asthma and Atopy

1999 • 15 citations

Mapping Human Interferon-alpha (IFN-α2) Binding Determinants of the Type I Interferon Receptor Subunit IFNAR-1 with Human/Bovine IFNAR-1 Chimeras

1998 • 13 citations

[72] Measurement of interferon in human amniotic fluid and placental blood extract

1986 • 11 citations

IL-10 signaling via IL-10E1 is dependent on tyrosine phosphorylation in the IL-10R α chain in human primary prostate cancer cell lines

2003 • 11 citations

AUGMENTATION OF HUMAN NATURAL KILLER CELLS WITH HUMAN LEUKOCYTE AND HUMAN RECOMBINANT LEUKOCYTE INTERFERON

1982 • 10 citations

[77] Cloning of the human interferons

1981 • 10 citations

Structure of the human CRFB4 gene: Comparison with its IFNAR neighbor

1995 • 9 citations

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