Molecular mechanisms of inactivation of TGF-β receptors during carcinogenesis

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

1992 • 1,787 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1994 • 1,205 citations

The Transforming Growth Factor-βs

1991 • 882 citations

Peptide growth factors are multifunctional

1988 • 835 citations

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

1995 • 824 citations

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

1995 • 743 citations

A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS–family transcription factor, ERG

1994 • 727 citations

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.

1995 • 635 citations

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

1993 • 560 citations

Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene.

1991 • 467 citations

A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.

1995 • 466 citations

A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability.

1995 • 445 citations

Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta.

1994 • 431 citations

Tumor suppressor activity of the TGF-β pathway in human cancers

1996 • 412 citations

DNA methylation errors and cancer.

1996 • 405 citations

Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.

1999 • 395 citations

Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein

1999 • 338 citations

Absence of TGF-β Receptors and Growth Inhibitory Responses in Retinoblastoma Cells

1988 • 331 citations

Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells

1994 • 325 citations

The ets gene family

1992 • 308 citations

Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein

1992 • 258 citations

Microsatellite instability in inherited and sporadic neoplasms

1995 • 257 citations

Mutation of the type II transforming growth factor-beta receptor is coincident with the transformation of human colon adenomas to malignant carcinomas.

1998 • 249 citations

Loss of receptors for transforming growth factor beta in human T-cell malignancies.

1994 • 219 citations

Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells.

1995 • 216 citations

Isolation and Characterization of a Novel Epithelium-Specific Transcription Factor, ESE-1, a Member of the ets Family

1997 • 215 citations

Genetic change in transforming growth factor beta (TGF-beta) receptor type I gene correlates with insensitivity to TGF-beta 1 in human prostate cancer cells.

1996 • 195 citations

ESX: a structurally unique Ets overexpressed early during human breast tumorigenesis

1997 • 180 citations

ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation.

1995 • 163 citations

EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic

1997 • 159 citations

Transforming growth factor beta type I receptor kinase mutant associated with metastatic breast cancer.

1998 • 154 citations

A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer

1997 • 147 citations

The Clinicopathological Features of Gastric Carcinomas with Microsatellite Instability May Be Mediated by Mutations of Different “Target Genes”

1998 • 147 citations

A Dominant Inhibitory Mutant of the Type II Transforming Growth Factor β Receptor in the Malignant Progression of a Cutaneous T-Cell Lymphoma

1996 • 146 citations

Transcriptional repression of the transforming growth factor-β type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancer

1999 • 135 citations

Reduced Expression of Transforming Growth Factor β Type I Receptor Contributes to the Malignancy of Human Colon Carcinoma Cells

1996 • 122 citations

Characterization of the Promoter Region of the Human Transforming Growth Factor-β Type II Receptor Gene

1995 • 116 citations

A Novel ets-related Transcription Factor, ERT/ESX/ESE-1, Regulates Expression of the Transforming Growth Factor-β Type II Receptor

1998 • 110 citations

Transforming growth factor beta type II receptor gene mutations in adenomas from hereditary nonpolyposis colorectal cancer

1997 • 107 citations

The expression of a novel, epithelium-specific ets transcription factor is restricted to the most differentiated layers in the epidermis

1997 • 107 citations

Mutations of the Transforming Growth Factor-β Type II Receptor Gene and Genomic Instability in Hereditary Nonpolyposis Colorectal Cancer

1995 • 103 citations

Microsatellite instability-associated mutations associate preferentially with the intestinal type of primary gastric carcinomas in a high-risk population.

1996 • 101 citations

Loss of functional cell surface transforming growth factor β (TGF-β) type 1 receptor correlates with insensitivity to TGF-β in chronic lymphocytic leukemia

1997 • 101 citations

Structural alterations of transforming growth factor-? receptor genes in human cervical carcinoma

1999 • 100 citations

Type I transforming growth factor beta receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract.

1998 • 98 citations

Genomic structure of the transforming growth factor beta type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers.

1996 • 96 citations

Clinicopathological significance of altered loci of replication error and microsatellite instability-associated mutations in gastric cancer.

1998 • 95 citations

Characterization of the ets oncogene family member, fli-1.

1993 • 91 citations

Mutational analysis of the transforming growth factor beta receptor type II gene in human ovarian carcinoma.

1998 • 87 citations

Expression of transforming growth factor beta type II receptor reduces tumorigenicity in human gastric cancer cells.

1997 • 83 citations

A transforming growth factor beta type II receptor gene mutation common in sporadic cecum cancer with microsatellite instability.

1996 • 80 citations

Microsatellite instability in European hepatocellular carcinoma

1999 • 80 citations

Microsatellite instability and mutated type II transforming growth factor-β receptor gene in gliomas

1997 • 79 citations

Transforming growth factor-beta and cancer: a love-hate relationship?

1997 • 76 citations

Correction: Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein

1999 • 72 citations

Overexpression of human cyclin D1 reduces the transforming growth factor beta (TGF-beta) type II receptor and growth inhibition by TGF-beta 1 in an immortalized human esophageal epithelial cell line.

1994 • 71 citations

Transfection of the type I TGF-β receptor restores TGF-β responsiveness in pancreatic cancer

1998 • 69 citations

Induction of transforming growth factor beta 1 resistance by the E1A oncogene requires binding to a specific set of cellular proteins.

1991 • 69 citations

Inactivation of the transforming growth factor β type II receptor in human small cell lung cancer cell lines

1999 • 68 citations

Induction of Transforming Growth Factor-β Receptor Type II Expression in Estrogen Receptor-positive Breast Cancer Cells through SP1 Activation by 5-Aza-2′-deoxycytidine

1998 • 66 citations

Structure and expression of the promoter for the R4/ALK5 human type I transforming growth factor-β receptor: regulation by TGF-β

1996 • 62 citations

Transforming growth factor-beta receptor type 2 mutations and microsatellite instability in sporadic colorectal adenomas and carcinomas.

1997 • 59 citations

Frequent inactivation of the transforming growth factor beta type II receptor in small-cell lung carcinoma cells.

1997 • 58 citations

Mutation Analysis of the Transforming Growth Factor β Type II Receptor in Sporadic Human Cancers of the Pancreas, Liver, and Breast

1996 • 58 citations

A mutation in the transforming growth factor beta type II receptor gene promoter associated with loss of gene expression.

1996 • 54 citations

Mutation analysis of transforming growth factor beta type II receptor, Smad2, and Smad4 in hepatocellular carcinoma.

1999 • 54 citations

Microsatellite Instability and Frameshift Mutations in BAX and Transforming Growth Factor-β RII Genes Are Very Uncommon in Acute Lymphoblastic Leukemia In Vivo But Not in Cell Lines

1998 • 52 citations

Gene mutation of transforming growth factor ?1 type II receptor in hepatocellular carcinoma

1999 • 52 citations

Analyses of microsatellite instability and the transforming growth factor‐β receptor type II gene mutation in sporadic breast cancer and their correlation with clinicopathological features

1999 • 47 citations

Mutations of the transforming growth factor β type II receptor gene and microsatellite instability in gastric cancer

1996 • 46 citations

Genetic integrity of transforming growth factor β (TGF-β) receptors in cervical carcinoma cell lines: loss of growth sensitivity but conserved transcriptional response to TGF-β

1998 • 44 citations

Infrequent mutations of the transforming growth factor beta-type II receptor gene at chromosome 3p22 in human lung cancers with chromosome 3p deletions

1997 • 37 citations

The TGF-β type II receptor in chronic myeloid leukemia: analysis of microsatellite regions and gene expression

1999 • 36 citations

The S387Y mutations of the transforming growth factor-beta receptor type I gene is uncommon in metastases of breast cancer and other common types of adenocarcinoma.

1999 • 36 citations

Mutational Analysis of Activin/Transforming Growth Factor-β Type I and Type II Receptor Kinases in Human Pituitary Tumors¹

1999 • 35 citations

RER phenotype and its associated mutations in familial gastric cancer

1998 • 35 citations

Mechanism of E1A-Induced Transforming Growth Factor-β (TGF-β) Resistance in Mouse Keratinocytes Involves Repression of TGF-β Type II Receptor Transcription

1997 • 35 citations

Two Divergent Signaling Pathways for TGF-β Separated by a Mutation of Its Type II Receptor Gene

1999 • 35 citations

Truncation of the TGF-β type II receptor gene results in insensitivity to TGF-β in human gastric cancer cells

1999 • 33 citations

Frequent aberration of the transforming growth factor-? receptor II gene in cell lines but no apparent mutation in pre-invasive and invasive carcinomas of the uterine cervix

1999 • 30 citations

Absence of mutations in the analysis of coding sequences of the entire transforming growth factor-beta type II receptor gene in sporadic human breast cancers.

1998 • 29 citations

Transforming growth factor-β receptors: Role in physiology and disease

1996 • 29 citations

Relationship between intratumor histological heterogeneity and genetic abnormalities in gastric carcinoma with microsatellite instability

1999 • 27 citations

Analysis of microsatellite instability, TGF-beta type II receptor gene mutations and hMSH2 and hMLH1 allele losses in pancreaticobiliary maljunction-associated biliary tract tumors.

1999 • 25 citations

Microsatellite instability is an early genetic event in myelodysplastic syndrome but is infrequent and not associated with TGF-beta receptor type II gene mutation.

1996 • 24 citations

Relationship between intratumor histological heterogeneity and genetic abnormalities in gastric carcinoma with microsatellite instability

1999 • 23 citations

Lack of transforming growth factor-β type II receptor expression in human retinoblastoma cells

1998 • 21 citations

Analyses of mutation and loss of heterozygosity of coding sequences of the entire transforming growth factor beta type II receptor gene in sporadic human gastric cancer

1998 • 20 citations

Functional characterization of transforming growth factor beta type II receptor mutants in human cancer.

1998 • 18 citations

Mutation of the transforming growth factor-beta type II receptor gene is a rare event in human sporadic gastric carcinomas.

1998 • 17 citations

Microsatellite alterations andp53, TGFβRII, IGFIIR andBAX mutations in sporadic non-small-cell lung cancer

1998 • 15 citations

Mutational Analysis of Activin/Transforming Growth Factor- Type I and Type II Receptor Kinases in Human Pituitary Tumors

1999 • 14 citations

Genetic alterations are frequent in APC but rare in the TGF-β type II receptor gene in cancer in adenomas of the colon

1998 • 10 citations

Transforming growth factor J3 type II receptor (TGFpRII) mutation in gastric lymphoma without mutator phenotype

1998 • 9 citations