The role of IL-6 and STAT3 in inflammation and cancer

Inflammation and cancer

2002 • 14,174 citations

Stat3 as an Oncogene

1999 • 2,770 citations

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

1998 • 2,072 citations

Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines.

2003 • 1,035 citations

IL-6 in autoimmune disease and chronic inflammatory proliferative disease

2002 • 793 citations

SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity

2001 • 695 citations

IL-6 signal transduction and its physiological roles: the signal orchestration model

2003 • 673 citations

JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis

2004 • 659 citations

Chronic Inflammation and Cancer

2013 • 585 citations

Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B

1996 • 582 citations

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

2003 • 562 citations

Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma

2001 • 492 citations

Interleukin‐6: A Cytokine for Gerontolgists

1993 • 457 citations

Nitric oxide and oxygen radicals in infection, inflammation, and cancer.

1998 • 425 citations

Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity.

1995 • 423 citations

Interleukin‐6 (IL‐6) functions as an in vitro autocrine growth factor in renal cell carcinomas

1989 • 420 citations

Novel Roles of Unphosphorylated STAT3 in Oncogenesis and Transcriptional Regulation

2005 • 392 citations

THE ROLE OF INFLAMMATION IN THE PATHOGENESIS OF PROSTATE CANCER

2004 • 392 citations

Regulation of macrophage activation

2003 • 354 citations

Inflammation and the development of pancreatic cancer

2002 • 334 citations

SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma

2003 • 311 citations

STAT family of transcription factors in cytokine-mediated biological responses

2000 • 311 citations

Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro.

1997 • 308 citations

Negative regulation of the JAK/STAT pathway

1999 • 288 citations

Activation of NK cells by CC chemokines. Chemotaxis, Ca2+ mobilization, and enzyme release.

1996 • 284 citations

Oxidative Stress Triggers STAT3 Tyrosine Phosphorylation and Nuclear Translocation in Human Lymphocytes

1999 • 256 citations

Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells.

2000 • 256 citations

JAK/STAT signaling by cytokine receptors

1998 • 242 citations

Interleukin-6 (IL-6) Production by Astrocytes: Autocrine Regulation by IL-6 and the Soluble IL-6 Receptor

1999 • 229 citations

Survival and Proliferation Factors of Normal and Malignant Plasma Cells

2003 • 216 citations

Rapid Viral Induction of Plasmacytomas in Pristane-Primed BALB/c Mice

1973 • 179 citations

Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression

1998 • 177 citations

Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma

2003 • 169 citations

Chronic immune activation and inflammation in the pathogenesis of aids and cancer

2002 • 164 citations

JAK3, STAT, and MAPK Signaling Pathways as Novel Molecular Targets for the Tyrphostin AG-490 Regulation of IL-2-Mediated T Cell Response

1999 • 164 citations

Interleukin-6 acts as an antiapoptotic factor in human esophageal carcinoma cells through the activation of both STAT3 and mitogen-activated protein kinase pathways

2003 • 164 citations

Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells

2003 • 163 citations

Green Tea Polyphenol Causes Differential Oxidative Environments in Tumor versus Normal Epithelial Cells

2003 • 159 citations

Mcl‐1 and Bcl‐x_L are co‐regulated by IL‐6 in human myeloma cells

1999 • 157 citations

Autocrine interleukin-6 production and highly malignant multiple myeloma: relation with resistance to drug-induced apoptosis

2001 • 151 citations

Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody

1998 • 148 citations

The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti–multiple myeloma (MM) activity and overcome bortezomib resistance

2003 • 136 citations

KSHV-encoded viral IL-6 activates multiple human IL-6 signaling pathways

1999 • 135 citations

Lack of Phosphotyrosine Phosphatase SHP-1 Expression in Malignant T-Cell Lymphoma Cells Results from Methylation of the SHP-1 Promoter

2000 • 133 citations

IL-6 transgenic mouse model for extraosseous plasmacytoma

2002 • 133 citations

Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma

2003 • 131 citations

Cytokines and STAT Signaling

1999 • 128 citations

The Interaction of Specific Peptide Aptamers With the DNA Binding Domain and the Dimerization Domain of the Transcription Factor Stat3 Inhibits Transactivation and Induces Apoptosis in Tumor Cells

2004 • 127 citations

A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells

2005 • 123 citations

Transcriptional Inactivation of STAT3 by PPARγ Suppresses IL-6-Responsive Multiple Myeloma Cells

2004 • 122 citations

Mutational Analysis of Acute-Phase Response Factor/Stat3 Activation and Dimerization

1997 • 121 citations

Interleukin-6 (IL-6) Functions as an Autocrine Growth Factor in Cervical Carcinomas in Vitro

1993 • 120 citations

Chemokines integrate JAK/STAT and G‐protein pathways during chemotaxis and calcium flux responses

2003 • 113 citations

Expression of the bcl‐2 family of pro‐ and anti‐apoptotic genes in multiple myeloma and normal plasma cells

2002 • 103 citations

Prostaglandin E2 Stimulates Prostatic Intraepithelial Neoplasia Cell Growth through Activation of the Interleukin-6/GP130/STAT-3 Signaling Pathway

2002 • 102 citations

Constitutive Activation of STAT5 by a Point Mutation in the SH2 Domain

2000 • 99 citations

Histology of Developing Plasma Cell Neoplasia Induced By Mineral Oil in BALB/c Mice

1964 • 98 citations

Interleukin-6: historical background, genetics and biological significance

1990 • 98 citations

Analysis of Signal Transducer and Activator of Transcription 3 (Stat 3) Pathway in Multiple Myeloma

2003 • 94 citations

Sequence-specific Peptide Aptamers, Interacting with the Intracellular Domain of the Epidermal Growth Factor Receptor, Interfere with Stat3 Activation and Inhibit the Growth of Tumor Cells

2003 • 88 citations

Inhibition of plasmacytoma development in BALB/c mice by indomethacin.

1985 • 86 citations

IL-15, a survival factor for kidney epithelial cells, counteracts apoptosis and inflammation during nephritis

2002 • 85 citations

Structure‐Function analysis of human IL‐6: Identification of two distinct regions that are important for receptor binding

1994 • 85 citations

Gene profiling of a myeloma cell line reveals similarities and unique signatures among IL-6 response, N-ras-activating mutations, and coculture with bone marrow stromal cells

2003 • 85 citations

Chronic inflammation as inductor of pro-cancer microenvironment: pathogenesis of dysregulated feedback control.

2003 • 79 citations

IL-15, a survival factor for kidney epithelial cells, counteracts apoptosis and inflammation during nephritis

2002 • 72 citations

The CIS Family: Negative Regulators of JAK–STAT Signaling

1998 • 72 citations

Inflammation promotes survival and migration of the CG4 oligodendrocyte progenitors transplanted in the spinal cord of both inflammatory and demyelinated EAE rats

1998 • 69 citations

Human Herpesvirus 8 K1-Associated Nuclear Factor-kappa B-Dependent Promoter Activity: Role in Kaposi's Sarcoma Inflammation?

2000 • 69 citations

Targeted disruption of Stat6 DNA binding activity by an oligonucleotide decoy blocks IL-4–driven TH2 cell response

2000 • 67 citations

Discrete roles of cytokines, TNF-α, IL-1, IL-6 in tumor promotion and cell transformation

2002 • 67 citations

Protein tyrosine phosphatase εC selectively inhibits interleukin-6– and interleukin- 10–induced JAK-STAT signaling

2001 • 67 citations

Targeting Janus Kinase 3 in Mast Cells Prevents Immediate Hypersensitivity Reactions and Anaphylaxis

1999 • 66 citations

The IL-6 receptor antagonist SANT-7 overcomes bone marrow stromal cell-mediated drug resistance of multiple myeloma cells

2001 • 66 citations

Mouse plasmacytoma: an experimental model of human multiple myeloma.

2001 • 62 citations

NF-κB as a target for anti-inflammatory gene therapy: suppression of inflammatory responses in monocytic and stromal cells by stable gene transfer of IκBα cDNA

1997 • 59 citations

STAT 5 activators can replace the requirement of FBS in the adipogenesis of 3T3-L1 cells

2004 • 58 citations

Circulating cytokines as markers of systemic inflammatory response in severe community-acquired pneumonia

2003 • 55 citations

Targeting the sodium-dependent multivitamin transporter (SMVT) for improving the oral absorption properties of a retro-inverso Tat nonapeptide.

2001 • 54 citations

The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells

2004 • 46 citations

Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) in hematopoietic cells.

2000 • 40 citations

PIAS3 (protein inhibitor of activated STAT‐3) modulates the transcriptional activation mediated by the nuclear receptor coactivator TIF2

2002 • 37 citations

Role of a two-chain IL-6 receptor system in immune and hematopoietic cell regulation.

1992 • 31 citations

IL-6, M-CSF and IAP Cytokines in Ovarian Cancer: Simultaneous Assessment of Serum Levels

1999 • 30 citations

The cis decoy against the estrogen response element suppresses breast cancer cells via target disrupting c-fos not mitogen-activated protein kinase activity.

2003 • 26 citations

Dimerization and activation of the common transducing chain (gp130) of the cytokines of the IL-6 family by mAb.

1998 • 24 citations

Inhibition of Interleukin-6 Signaling and Stat3 Activation by a New Class of Bioactive Cyclopentenone Derivatives

2000 • 24 citations

Protein phosphatase type 2A, PP2A, is involved in degradation of gp130

2005 • 22 citations

Sequence, Expression and Function of an mRNA Encoding a Soluble Form of the Human Interleukin-6 Receptor (sIL-6R)

1995 • 20 citations

Activating Mutations in STAT3 and STAT5 Differentially Affect Cellular Proliferation and Apoptotic Resistance in Multiple Myeloma Cells

2004 • 19 citations

Bcl-2 antisense therapy in multiple myeloma.

2004 • 19 citations

IL-6 functions in cynomolgus monkeys blocked by a humanized antibody to human IL-6 receptor

1998 • 16 citations

IL-6 inhibits apoptosis of human myeloma cell line XG-7 through activation of JAK/STAT pathway and up-regulation of Mcl-1.

2002 • 14 citations

Cytokines and Soluble Cell Adhesion Molecules: Possible Markers of Inflammatory Response in Atherosclerosis

2000 • 14 citations

Inhibition of protein kinase C by retro-inverso pseudosubstrate analogues

1989 • 13 citations

A Monoclonal Anti-Human IL-6 Receptor Antibody Inhibits the Proliferation of Human Myeloma Cells

1993 • 11 citations

Identification of Predictors of Disease Status and Progression in Patients with Myeloma (MM)

2000 • 11 citations

Mcl-1 mediates cytokine deprivation induced apoptosis of human myeloma cell line XG-7.

2002 • 10 citations

Synthesis and activity of partial retro‐inverso analogs of the antimetastatic laminin‐derived peptide, YIGSR‐NH₂

1997 • 9 citations

Multiple myeloma: An immunoclinical study of disease and response to treatment

1995 • 9 citations

Cytokine-induced STAT signalling through the cytoplasmic compartment

2001 • 5 citations

Cervical cancer: chronic inflammation, stress and adaptation factors.

1956 • 4 citations

Plasma cell tumour-formation and antigen-binding myeloma proteins in mice.

1971 • 2 citations